Projects per year
Personal profile
Biography
A/Prof Marco Morsch is the Co-Director of Research in the Macquarie Medical School at Macquarie University.
A/Prof Morsch is a mid-career neuroscientist and group leader in the Macquarie Medical School of the Faculty of Medicine and Health, and Human Sciences at Macquarie University. Dr Morsch received his PhD from the University of Bonn, Germany, followed by a postdoctoral fellowship at the University of Sydney. In 2014 Marco moved to Macquarie University to work at the ‘Centre for MND Research’.
A/Prof Morsch has established the first Australian zebrafish platform to characterise the process of neurodegeneration and monitor the interactions of phagocytosing microglia in real-time in the CNS of a living vertebrate (zebrafish). His unique research program allowed him to make important advances in the study of neurological diseases and, more recently, in the underlying principles of neuron-glia interactions in the healthy and stressed nervous system.
In 2018 he was awarded the ‘Outstanding mid-career researcher’ prize by MND Research Institute of Australia.
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We have PhD and Masters opportunities available in our lab, including one fully funded domestic scholarships:
"Investigating neuron-glia interactions in MND/ALS" - Link here
People with an interest in MND, molecular, biology, and advanced microscopy techniques, please reach out.
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Research interests
A/Prof Morsch’s research program investigates the molecular & cellular pathways affected in neurodegeneration, using novel visualization techniques, advanced molecular tools, & innovative approaches to enhance drug delivery.
To study the underlying pathological mechanism of disease he has established unique live-imaging and laser-ablation protocols to accurately monitor the degeneration process of motor neurons in the CNS and its impact on surrounding cells.
Overall the zebrafish program closes a critical gap in the field by providing a preclinical animal model that allows real-time characterisation of cellular processes in the CNS.
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Characterising the interactome of sequestosome-1/(p62) – the peacemaker between protein homeostasis and dysfunction
Davidson, J., Lee, A., Morsch, M., Richter, G., Rea, S. & Di Ieva, A.
14/03/23 → 14/03/24
Project: Research
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Characterising the interactome of sequestosome-1 (p62) – the peacemaker between protein homeostasis and dysfunction
Davidson, J., Lee, A., Morsch, M., Richter, G., Di Ieva, A. & Rea, S.
1/01/23 → 31/12/23
Project: Research
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Microglia and the inflammation spectrum - not just good or bad
Morsch, M., Lee, A. & Williams, K.
1/01/21 → 31/12/23
Project: Research
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Development of a TDP43-targeting gene therapy for ALS
Chung, R., Lisowski, L., Walker, A. K., Rogers, M., Lee, A., Morsch, M. & Rayner, S.
1/10/20 → 30/09/23
Project: Research
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A laser platform to undertake single-cell-resolution experiments in zebrafish
Chung, R., Morsch, M., Laird, A. & Cole, N.
1/01/17 → …
Project: Research
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A transient protein folding response targets aggregation in the early phase of TDP-43-mediated disease
Gil, R. S., Pascovici, D., Venturato, J., Brown-Wright, H., Mehta, P., Martin, L. M. S., Wu, J., Chui, Y. K., Bademosi, A. T., Swaminathan, S., Luan, W., Berning, B. A., Wright, A. L., Keating, S. S., Lee, A., Morsch, M., Chung, R. S., Lisowski, L., Mirzaei, M. & Walker, A. K., 24 Jun 2023, (Submitted) 60 p. (bioRxiv).Research output: Working paper › Preprint
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Identification of phosphorylated Tau protein interactors in progressive supranuclear palsy (PSP) reveals networks involved in protein degradation, stress response, cytoskeletal dynamics, metabolic processes, and neurotransmission
Radford, R. A. W., Rayner, S. L., Szwaja, P., Morsch, M., Cheng, F., Zhu, T., Widagdo, J., Anggono, V., Pountney, D. L., Chung, R. & Lee, A., May 2023, In: Journal of Neurochemistry. 165, 4, p. 563-586 24 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Downloads (Pure) -
The E3 ubiquitin ligase SCF cyclin F promotes sequestosome-1/p62 insolubility and foci formation and is dysregulated in ALS and FTD pathogenesis
Davidson, J. M., Wu, S. S. L., Rayner, S. L., Cheng, F., Duncan, K., Russo, C., Newbery, M., Ding, K., Scherer, N. M., Balez, R., García-Redondo, A., Rábano, A., Rosa-Fernandes, L., Ooi, L., Williams, K. L., Morsch, M., Blair, I. P., Di Ieva, A., Yang, S., Chung, R. S., & 1 others , Sep 2023, In: Molecular Neurobiology. 60, 9, p. 5034-5054 21 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
Zebrafish: an emerging and expedient model for liver studies?
Shami, G. J., Cheng, D., Morsch, M. & Braet, F., Aug 2023, In: Liver International. 43, 8, p. 1839-1840 2 p.Research output: Contribution to journal › Letter › peer-review
1 Citation (Scopus) -
Aspect ratio of PEGylated upconversion nanocrystals affects the cellular uptake in vitro and in vivo
Fu, L., Shi, B., Wen, S., Morsch, M., Wang, G., Zhou, Z., Mi, C., Sadraeian, M., Lin, G., Lu, Y., Jin, D. & Chung, R., 15 Jul 2022, In: Acta Biomaterialia. 147, p. 403-413 11 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus)
Prizes
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Outstanding mid-career researcher MND Research Institute Australia
Morsch, Marco (Recipient), 9 Nov 2018
Prize
Activities
- 1 Participating in a conference, workshop or event series
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Faculty of Medicine and Health Sciences 2nd Annual EnCouRage Research Symposium
Dane Turner (Organiser), Angela Laird (Organiser), Emily Don (Organiser), Magdalena Lam (Organiser), Adam Keith Walker (Organiser), Marco Morsch (Organiser), Benjamin Heng (Organiser), Vanessa Tan (Organiser), Esther Lim (Organiser), Marina Junqueira Santiago (Organiser), Hami Shahheydari (Organiser), Luan Luu (Organiser) & Mark Butlin (Poster judge)
27 Oct 2017Activity: Participating in or organising an event › Participating in a conference, workshop or event series
Press/Media
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Outdoor Festival of Science at the Royal Botanic Garden Sydney 2019
18/08/19
1 Media contribution
Press/Media: Public Engagement Activities
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Will see-through fish help cure muscle-killing disease?
12/01/18
1 item of Media coverage
Press/Media: Other
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Making zebrafish glow to better understand motor neuron disease
17/10/17
1 Media contribution
Press/Media: Public Engagement Activities
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Glow in the dark creatures helping scientists identify toxic cells
20/05/17
1 item of Media coverage
Press/Media: Public Engagement Activities