Projects per year
Personal profile
Biography
Dr Marco Morsch is a mid-career neuroscientist and group leader at the Department of Biomedical Sciences of the Faculty of Medicine and Health Sciences at Macquarie University. Marco received his PhD in 2009 from the University of Bonn, Germany, followed by a postdoctoral fellowship at the University of Sydney. In 2014 Marco moved to Macquarie University to work at the ‘Centre for MND Research’.
Dr Morsch has established the first Australian zebrafish platform to characterise the process of neurodegeneration and monitor the interactions of phagocytosing microglia in real-time in the CNS of a living vertebrate (zebrafish). His unique research program allowed him to make important advances in the study of neurological diseases and, more recently, in the underlying principles of neuron-glia interactions in the healthy and stressed nervous system.
In 2018 he was awarded the ‘Outstanding mid-career researcher’ prize by MND Research Institute of Australia.
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We have PhD and Masters opportunities available in our lab, including one fully funded domestic scholarships:
"Investigating neuron-glia interactions in MND/ALS" - Link here
People with an interest in MND, molecular, biology, and advanced microscopy techniques, please reach out.
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Research interests
Dr Morsch’s research program investigates the molecular & cellular pathways affected in neurodegeneration, using novel visualization techniques, advanced molecular tools, & innovative approaches to enhance drug delivery.
To study the underlying pathological mechanism of disease he has established unique live-imaging and laser-ablation protocols to accurately monitor the degeneration process of motor neurons in the CNS and its impact on surrounding cells.
Overall the zebrafish program closes a critical gap in the field by providing a preclinical animal model that allows real-time characterisation of cellular processes in the CNS.
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Microglia and the inflammation spectrum - not just good or bad
Morsch, M., Lee, A. & Williams, K.
1/01/21 → 31/12/23
Project: Research
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Development of a TDP43-targeting gene therapy for ALS
Chung, R., Lisowski, L., Walker, A. K., Rogers, M., Lee, A., Morsch, M. & Rayner, S.
1/10/20 → 30/09/23
Project: Research
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CMNDR: Macquarie University Centre for Motor Neuron Disease Research
Atkin, J., Blair, I., Rowe, D., Atkin, J., Chung, R., Guillemin, G., Laird, A., Lee, A., Morsch, M., Shi, B., Williams, K. & Yang, S.
1/01/20 → 31/12/22
Project: Other
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Novel peripherally‐restricted cannabinoids to treat impaired neuromuscular synaptic transmission in myasthenia gravis and other neurological disorders
Phillips, W. D., McGregor, I. S., Arnold, J., Bowen, M. T., Banister, S., Reddel, S. W., Odierna, L. & Morsch, M.
20/11/18 → 31/12/22
Project: Research
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A laser platform to undertake single-cell-resolution experiments in zebrafish
Chung, R., Morsch, M., Laird, A. & Cole, N.
1/01/17 → …
Project: Research
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Brain-targeted aggregation-induced-emission nanoparticles with near-infrared imaging at 1550 nm boosts orthotopic glioblastoma theranostics
Wang, J., Liu, Y., Morsch, M., Lu, Y., Shangguan, P., Han, L., Wang, Z., Chen, X., Song, C., Liu, S., Shi, B. & Tang, B. Z., 3 Feb 2022, In: Advanced Materials. 34, 5, p. 1-9 9 p., e2106082.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
Brain-targeted codelivery of Bcl-2/Bcl-xl and Mcl-1 inhibitors by biomimetic nanoparticles for orthotopic glioblastoma therapy
He, W., Li, X., Morsch, M., Ismail, M., Liu, Y., Rehman, F. U., Zhang, D., Wang, Y., Zheng, M., Chung, R., Zou, Y. & Shi, B., 30 Mar 2022, In: ACS Nano. 16, p. 6293-6308 16 p.Research output: Contribution to journal › Article › peer-review
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Brain-Targeted polymersome codelivery of siRNA and temozolomide for effective glioblastoma chemo-RNAi synergistic therapy
Zheng, M., Yan, C., Yang, Q., Zhu, F., Du, Q., Xia, X., Morsch, M., Lee, A., Yin, J., Zou, Y. & Shi, B., 9 Feb 2022, (Accepted/In press) In: ChemPhysMater.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Enhanced antioxidant effects of the anti-inflammatory compound probucol when released from mesoporous silica particles
Lau, M., Sealy, B., Combes, V., Morsch, M. & Garcia-Bennett, A. E., Mar 2022, In: Pharmaceutics. 14, 3, p. 1-23 23 p., 502.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
TDP-43 is a ubiquitylation substrate of the SCFcyclin F complex
Rayner, S. L., Yang, S., Farrawell, N. E., Jagaraj, C. J., Cheng, F., Davidson, J. M., Luu, L., Redondo, A. G., Rábano, A., Borrego-Hernández, D., Atkin, J. D., Morsch, M., Blair, I. P., Yerbury, J. J., Chung, R. & Lee, A., 1 Jun 2022, In: Neurobiology of Disease. 167, p. 1-11 11 p., 105673.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Downloads (Pure)
Prizes
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Outstanding mid-career researcher MND Research Institute Australia
Morsch, Marco (Recipient), 9 Nov 2018
Prize
Activities
- 1 Participating in a conference, workshop or event series
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Faculty of Medicine and Health Sciences 2nd Annual EnCouRage Research Symposium
Dane Turner (Organiser), Angela Laird (Organiser), Emily Don (Organiser), Magdalena Lam (Organiser), Adam Keith Walker (Organiser), Marco Morsch (Organiser), Benjamin Heng (Organiser), Vanessa Tan (Organiser), Esther Lim (Organiser), Marina Junqueira Santiago (Organiser), Hami Shahheydari (Organiser), Luan Luu (Organiser) & Mark Butlin (Poster judge)
27 Oct 2017Activity: Participating in or organising an event › Participating in a conference, workshop or event series
Press / Media
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Outdoor Festival of Science at the Royal Botanic Garden Sydney 2019
18/08/19
1 Media contribution
Press/Media: Public Engagement Activities
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Will see-through fish help cure muscle-killing disease?
12/01/18
1 item of Media coverage
Press/Media: Other
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Making zebrafish glow to better understand motor neuron disease
17/10/17
1 Media contribution
Press/Media: Public Engagement Activities
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Glow in the dark creatures helping scientists identify toxic cells
20/05/17
1 item of Media coverage
Press/Media: Public Engagement Activities