Projects per year
Personal profile
Biography
Dr Marco Morsch is a mid-career neuroscientist and group leader at the Department of Biomedical Sciences of the Faculty of Medicine and Health Sciences at Macquarie University. Marco received his PhD in 2009 from the University of Bonn, Germany, followed by a postdoctoral fellowship at the University of Sydney. In 2014 Marco moved to Macquarie University to work at the ‘Centre for MND Research’.
Dr Morsch has established the first Australian zebrafish platform to characterise the process of neurodegeneration and monitor the interactions of phagocytosing microglia in real-time in the CNS of a living vertebrate (zebrafish). His unique research program allowed him to make important advances in the study of neurological diseases and, more recently, in the underlying principles of neuron-glia interactions in the healthy and stressed nervous system.
In 2018 he was awarded the ‘Outstanding mid-career researcher’ prize by MND Research Institute of Australia.
Research interests
Dr Morsch’s research program investigates the molecular & cellular pathways affected in neurodegeneration, using novel visualization techniques, advanced molecular tools, & innovative approaches to enhance drug delivery.
To study the underlying pathological mechanism of disease he has established unique live-imaging and laser-ablation protocols to accurately monitor the degeneration process of motor neurons in the CNS and its impact on surrounding cells.
Overall the zebrafish program closes a critical gap in the field by providing a preclinical animal model that allows real-time characterisation of cellular processes in the CNS.
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Projects
Clearance of TDP-43 by PROteolysis TArgeting Chimera (PROTAC) dual targeting to treat amyotrophic lateral sclerosis (ALS)
Lee, A., Rayner, S., Martin, A., van Hummel, A., Morsch, M., Shi, B., Ke, Y., Ittner, L. & Chung, R.
4/05/20 → 3/05/21
Project: Research
CMNDR: Macquarie University Centre for Motor Neuron Disease Research
Atkin, J., Blair, I., Rowe, D., Atkin, J., Chung, R., Guillemin, G., Laird, A., Lee, A., Morsch, M., Shi, B., Williams, K. & Yang, S.
1/01/20 → 31/12/22
Project: Other
Targeting the nucleo-cytoplasmic transport machinery in sporadic and familial ALS
Morsch, M., Lee, A., Walker, A. K. & Chung, R.
1/06/19 → 31/05/20
Project: Research
Novel peripherally‐restricted cannabinoids to treat impaired neuromuscular synaptic transmission in myasthenia gravis and other neurological disorders
Phillips, W. D., McGregor, I. S., Arnold, J., Bowen, M. T., Banister, S., Reddel, S. W., Odierna, L. & Morsch, M.
20/11/18 → 31/12/22
Project: Research
Snow Foundation Co-funded Fellowship: Determining the molecular pathogenesis of MND
27/07/18 → 26/07/21
Project: Other
Research Outputs
BioID analysis of the cyclin F interactome reveals that ALS-variant cyclin F alters the homeostasis of paraspeckle-associated proteins
Rayner, S. L., Cheng, F., Yang, S., Grima, N., Ke, Y. D., Au, C. G., Morsch, M., Luca, A. D., Davidson, J. M., Molloy, M. P., Shi, B., Ittner, L. M., Blair, I., Chung, R. S. & Lee, A., 1 May 2020, (In preparation) In : bioRxiv.Research output: Contribution to journal › Article
Observation and characterisation of macrophages in zebrafish liver
Cheng, D., Morsch, M., Shami, G. J., Chung, R. S. & Braet, F., 1 May 2020, In : Micron. 132, p. 1-12 12 p., 102851.Research output: Contribution to journal › Article
Albumin uptake and distribution in the zebrafish liver as observed via correlative imaging
Cheng, D., Morsch, M., Shami, G. J., Chung, R. S. & Braet, F., 1 Jan 2019, In : Experimental Cell Research. 374, 1, p. 162-171 10 p.Research output: Contribution to journal › Article
1
Citation
(Scopus)
Muscle specific kinase protects dystrophic mdx mouse muscles from eccentric contraction-induced loss of force-producing capacity
Trajanovska, S., Ban, J., Huang, J., Gregorevic, P., Morsch, M., Allen, D. G. & Phillips, W. D., Sep 2019, In : Journal of Physiology. 597, 18, p. 4831-4850 20 p.Research output: Contribution to journal › Article
Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy.
Lee, A., Rayner, S. L., Gwee, S. S. L., De Luca, A., Shahheydari, H., Sundaramoorthy, V., Morsch, M., Hogan, A., Don, E., Williams, K., Yerbury, J. J., Blair, I., Atkin, J. D., Molloy, M. P. & Chung, R. S., 8 Feb 2019. 1 p.Research output: Contribution to conference › Abstract
Prizes
Outstanding mid-career researcher MND Research Institute Australia
Marco Morsch (Recipient), 9 Nov 2018
Prize
Press / Media
Outdoor Festival of Science at the Royal Botanic Garden Sydney 2019
18/08/19
1 Media contribution
Press/Media: Public Engagement Activities
Will see-through fish help cure muscle-killing disease?
12/01/18
1 item of Media coverage
Press/Media: Other
Making zebrafish glow to better understand motor neuron disease
17/10/17
1 Media contribution
Press/Media: Public Engagement Activities
Glow in the dark creatures helping scientists identify toxic cells
20/05/17
1 item of Media coverage
Press/Media: Public Engagement Activities