• 581 Citations
  • 14 h-Index
20092022

Research output per year

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Personal profile

Biography

Dr Marco Morsch is a mid-career neuroscientist and group leader at the Department of Biomedical Sciences of the Faculty of Medicine and Health Sciences at Macquarie University. Marco received his PhD in 2009 from the University of Bonn, Germany, followed by a postdoctoral fellowship at the University of Sydney. In 2014 Marco moved to Macquarie University to work at the ‘Centre for MND Research’.

Dr Morsch has established the first Australian zebrafish platform to characterise the process of neurodegeneration and monitor the interactions of phagocytosing microglia in real-time in the CNS of a living vertebrate (zebrafish). His unique research program allowed him to make important advances in the study of neurological diseases and, more recently, in the underlying principles of neuron-glia interactions in the healthy and stressed nervous system.

In 2018 he was awarded the ‘Outstanding mid-career researcher’ prize by MND Research Institute of Australia.

Research interests

Dr Morsch’s research program investigates the molecular & cellular pathways affected in neurodegeneration, using novel visualization techniques, advanced molecular tools, & innovative approaches to enhance drug delivery.

To study the underlying pathological mechanism of disease he has established unique live-imaging and laser-ablation protocols to accurately monitor the degeneration process of motor neurons in the CNS and its impact on surrounding cells.

Overall the zebrafish program closes a critical gap in the field by providing a preclinical animal model that allows real-time characterisation of cellular processes in the CNS.

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Projects

Research Outputs

  • Observation and characterisation of macrophages in zebrafish liver

    Cheng, D., Morsch, M., Shami, G. J., Chung, R. S. & Braet, F., 1 May 2020, In : Micron. 132, p. 1-12 12 p., 102851.

    Research output: Contribution to journalArticle

  • Albumin uptake and distribution in the zebrafish liver as observed via correlative imaging

    Cheng, D., Morsch, M., Shami, G. J., Chung, R. S. & Braet, F., 1 Jan 2019, In : Experimental Cell Research. 374, 1, p. 162-171 10 p.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)

    Muscle specific kinase protects dystrophic mdx mouse muscles from eccentric contraction-induced loss of force-producing capacity

    Trajanovska, S., Ban, J., Huang, J., Gregorevic, P., Morsch, M., Allen, D. G. & Phillips, W. D., Sep 2019, In : Journal of Physiology. 597, 18, p. 4831-4850 20 p.

    Research output: Contribution to journalArticle

  • Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy.

    Lee, A., Rayner, S. L., Gwee, S. S. L., De Luca, A., Shahheydari, H., Sundaramoorthy, V., Morsch, M., Hogan, A., Don, E., Williams, K., Yerbury, J. J., Blair, I., Atkin, J. D., Molloy, M. P. & Chung, R. S., 8 Feb 2019. 1 p.

    Research output: Contribution to conferenceAbstract

  • Prizes

  • Press / Media

    Outdoor Festival of Science at the Royal Botanic Garden Sydney 2019

    Marco Morsch

    18/08/19

    1 Media contribution

    Press/Media: Public Engagement Activities

    Will see-through fish help cure muscle-killing disease?

    Marco Morsch

    12/01/18

    1 item of Media coverage

    Press/Media: Other

    Making zebrafish glow to better understand motor neuron disease

    Marco Morsch

    17/10/17

    1 Media contribution

    Press/Media: Public Engagement Activities

    Glow in the dark creatures helping scientists identify toxic cells

    Marco Morsch

    20/05/17

    1 item of Media coverage

    Press/Media: Public Engagement Activities