• 604 Citations
  • 14 h-Index
20092020

Research output per year

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Research Outputs

2020

Foreword to the special issue on zebrafish imaging: emerging techniques and methodologies

Morsch, M., Braet, F. & Cheng, D., 14 May 2020, In : Micron. 136, 1 p., 102877.

Research output: Contribution to journalEditorial

Observation and characterisation of macrophages in zebrafish liver

Cheng, D., Morsch, M., Shami, G. J., Chung, R. S. & Braet, F., 1 May 2020, In : Micron. 132, p. 1-12 12 p., 102851.

Research output: Contribution to journalArticle

2019

Albumin uptake and distribution in the zebrafish liver as observed via correlative imaging

Cheng, D., Morsch, M., Shami, G. J., Chung, R. S. & Braet, F., 1 Jan 2019, In : Experimental Cell Research. 374, 1, p. 162-171 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Muscle specific kinase protects dystrophic mdx mouse muscles from eccentric contraction-induced loss of force-producing capacity

Trajanovska, S., Ban, J., Huang, J., Gregorevic, P., Morsch, M., Allen, D. G. & Phillips, W. D., Sep 2019, In : Journal of Physiology. 597, 18, p. 4831-4850 20 p.

Research output: Contribution to journalArticle

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy.

Lee, A., Rayner, S. L., Gwee, S. S. L., De Luca, A., Shahheydari, H., Sundaramoorthy, V., Morsch, M., Hogan, A., Don, E., Williams, K., Yerbury, J. J., Blair, I., Atkin, J. D., Molloy, M. P. & Chung, R. S., 8 Feb 2019. 1 p.

Research output: Contribution to conferenceAbstract

Riluzole does not ameliorate disease caused by cytoplasmic TDP-43 in a mouse model of amyotrophic lateral sclerosis

Wright, A. L., Le, S., Mehta, P., Gatta, P. D., Berning, B. A., Jacobs, K. R., Gul, H., Gil, R. S., Hedl, T. J., Riddell, W. R., Watson, O., Keating, S. S., Chung, R. S., Atkin, J. D., Lee, A., Shi, B., Blizzard, C. A., Morsch, M. & Walker, A. K., 29 Aug 2019, (In preparation) In : bioRxiv.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2018

Aurora kinase B regulates axonal outgrowth and regeneration in the spinal motor neurons of developing zebrafish

Gwee, S. S. L., Radford, R. A. W., Chow, S., Syal, M. D., Morsch, M., Formella, I., Lee, A., Don, E. K., Badrock, A. P., Cole, N. J., West, A. K., Cheung, S. N. S. & Chung, R. S., Dec 2018, In : Cellular and Molecular Life Sciences. 75, 23, p. 4269-4285 17 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Cannabinoid-induced increase of quantal size and enhanced neuromuscular transmission

Morsch, M., Protti, D. A., Cheng, D., Braet, F., Chung, R. S., Reddel, S. W. & Phillips, W. D., 16 Mar 2018, In : Scientific Reports. 8, p. 1-8 8 p., 4685.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
43 Downloads (Pure)

DNA nanoclew templated spherical nucleic acids for siRNA delivery

Ruan, W., Zheng, M., An, Y., Liu, Y., Lovejoy, D., Hao, M., Zou, Y., Lee, A., Yang, S., Lu, Y., Morsch, M., Chung, R. & Shi, B., 14 Apr 2018, In : Chemical Engineering Communications. 54, p. 3609-3612 4 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons

Svahn, A. J., Don, E. K., Badrock, A. P., Cole, N. J., Graeber, M. B., Yerbury, J. J., Chung, R. & Morsch, M., Sep 2018, In : Acta Neuropathologica. 136, 3, p. 445-459 15 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
24 Downloads (Pure)

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy

Lee, A., Rayner, S. L., Gwee, S. S. L., De Luca, A., Shahheydari, H., Sundaramoorthy, V., Ragagnin, A., Morsch, M., Radford, R., Galper, J., Freckleton, S., Shi, B., Walker, A. K., Don, E. K., Cole, N. J., Yang, S., Williams, K. L., Yerbury, J. J., Blair, I. P., Atkin, J. D. & 2 others, Molloy, M. P. & Chung, R. S., Jan 2018, In : Cellular and Molecular Life Sciences. 75, 2, p. 335–354 20 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Real-time visualization of oxidative stress-mediated neurodegeneration of individual spinal motor neurons in vivo

Formella, I., Svahn, A. J., Radford, R. A. W., Don, E. K., Cole, N. J., Hogan, A., Lee, A., Chung, R. S. & Morsch, M., 1 Oct 2018, In : Redox Biology. 19, p. 226-234 9 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
93 Downloads (Pure)

Selective spatiotemporal vulnerability of central nervous system neurons to pathologic TAR DNA-binding protein 43 in aged transgenic mice

van Hummel, A., Chan, G., van der Hoven, J., Morsch, M., Ippati, S., Suh, L., Bi, M., Asih, P. R., Lee, W. S., Butler, T. A., Przybyla, M., Halliday, G. M., Piguet, O., Kiernan, M. C., Chung, R. S., Ittner, L. M. & Ke, Y. D., 1 Jun 2018, In : American Journal of Pathology. 188, 6, p. 1447-1456 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The mouse passive-transfer model of MuSK myasthenia gravis: disrupted MuSK signaling causes synapse failure

Ghazanfari, N., Trajanovska, S., Morsch, M., Liang, S. X., Reddel, S. W. & Phillips, W. D., Jan 2018, In : Annals of the New York Academy of Sciences. 1412, 1, p. 54-61 8 p.

Research output: Contribution to journalReview article

5 Citations (Scopus)
2017

A Tol2 Gateway-Compatible Toolbox for the Study of the Nervous System and Neurodegenerative Disease

Don, E. K., Formella, I., Badrock, A. P., Hall, T. E., Morsch, M., Hortle, E., Hogan, A., Chow, S., Gwee, S. S. L., Stoddart, J. J., Nicholson, G., Chung, R. & Cole, N. J., 1 Feb 2017, In : Zebrafish. 14, 1, p. 69-72 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

A Versatile upconversion surface evaluation platform for bio-nano surface selection for the nervous system

Fu, L., Morsch, M., Shi, B., Wang, G., Lee, A., Radford, R., Lu, Y., Jin, D. & Chung, R., 17 Aug 2017, In : Nanoscale. 9, 36, p. 13683-13692 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex

Lee, A., Rayner, S. L., De Luca, A., Gwee, S. S. L., Morsch, M., Sundaramoorthy, V., Shahheydari, H., Ragagnin, A., Shi, B., Yang, S., Williams, K. L., Don, E. K., Walker, A. K., Zhang, K. Y., Yerbury, J. J., Cole, N. J., Atkin, J. D., Blair, I. P., Molloy, M. P. & Chung, R. S., 2017, In : Open Biology. 7, 10, p. 1-11 11 p., 170058.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
13 Downloads (Pure)

Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype

Hogan, A. L., Don, E. K., Rayner, S. L., Lee, A., Laird, A. S., Watchon, M., Winnick, C., Tarr, I. S., Morsch, M., Fifita, J. A., Gwee, S. S. L., Formella, I., Hortle, E., Yuan, K. C., Molloy, M. P., Williams, K. L., Nicholson, G. A., Chung, R. S., Blair, I. P. & Cole, N. J., 15 Jul 2017, In : Human molecular genetics. 26, 14, p. 2616-2626 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Improving the delivery of SOD1 antisense oligonucleotides to motor neurons using calcium phosphate-lipid nanoparticle

Chen, L., Watson, C., Morsch, M., Cole, N. J., Chung, R. S., Saunders, D. N., Yerbury, J. J. & Vine, K. L., 30 Aug 2017, In : Frontiers in Neuroscience. 11, AUG, p. 1-12 12 p., 476.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
3 Downloads (Pure)

Multifunctional hybrid nanoparticles for traceable drug delivery and intracellular microenvironment-controlled multistage drug-release in neurons

Shi, B., Du, X., Chen, J., Fu, L., Morsch, M., Lee, A., Liu, Y., Cole, N. & Chung, R., 24 May 2017, In : Small. 13, 20, p. 1-10 10 p., 1603966.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Relocation is the key to successful correlative fluorescence and scanning electron microscopy

Cheng, D., Shami, G. J., Morsch, M., Huynh, M., Trimby, P. & Braet, F., 2017, Methods in cell biology: Correlative light and electron microscopy III. Müller-Reichert, T. & Verkade, P. (eds.). Academic Press, Vol. 140. p. 215-244 30 p. (Methods in cell biology).

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Triggering cell stress and death using conventional UV laser confocal microscopy

Morsch, M., Radford, R. A. W., Don, E. K., Lee, A., Hortle, E., Cole, N. J. & Chung, R. S., 2 Mar 2017, In : Journal of visualized experiments : JoVE. 2017, 120, p. 1-9 9 p., e54983.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Utility and reliability of non-invasive muscle function tests in high-fat-fed mice

Martinez-Huenchullan, S. F., Mclennan, S. V., Ban, L. A., Morsch, M., Twigg, S. M. & Tam, C. S., 1 Jun 2017, In : Experimental Physiology. 102, 7, p. 773-778 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Ultrastructural Mapping of the Zebrafish gastrointestinal system as a basis for experimental drug studies

Cheng, D., Shami, G. J., Morsch, M., Chung, R. S. & Braet, F., 2016, In : BioMed Research International. 2016, p. 1-13 13 p., 8758460.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
36 Downloads (Pure)
2015

Anti-musk myasthenia gravis: synapse loss due to blockade of tyrosine kinase signalling?

Phillips, W., Ghazanfari, N., Linsao, E., Trajanovska, S., Morsch, M., Gregorevic, P. & Reddel, S., Aug 2015, In : Journal of Neurochemistry. 134, S1, p. 268 1 p., WTH04-08.

Research output: Contribution to journalMeeting abstract

Assessment of neuro-muscular function tests in mouse models of obesity and diabetes

Huenchullan, S. M., Power, J., Yee, C., Morsch, M., McLennan, S., Twigg, S. & Tam, C., 15 Oct 2015, In : Journal of the Neurological Sciences. 357, S1, p. e203 1 p., 630.

Research output: Contribution to journalMeeting abstract

Electrophysiological analysis of neuromuscular synaptic function in myasthenia gravis patients and animal models

Plomp, J. J., Morsch, M., Phillips, W. D. & Verschuuren, J. J. G. M., Aug 2015, In : Experimental Neurology. 270, p. 41-54 14 p.

Research output: Contribution to journalReview article

31 Citations (Scopus)

Forced expression of muscle specific kinase slows postsynaptic acetylcholine receptor loss in a mouse model of musk myasthenia gravis

Ghazanfari, N., Linsao, E. L. T. B., Trajanovska, S., Morsch, M., Gregorevic, P., Liang, S. X., Reddel, S. W. & Phillips, W. D., Dec 2015, In : Physiological Reports. 3, 12, p. 1-15 15 p., e12658.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
11 Downloads (Pure)

In vivo characterization of microglial engulfment of dying neurons in the zebrafish spinal cord

Morsch, M., Radford, R., Lee, A., Don, E. K., Badrock, A. P., Hall, T. E., Cole, N. J. & Chung, R., 31 Aug 2015, In : Frontiers in Cellular Neuroscience. 9, p. 1-11 11 p., 321.

Research output: Contribution to journalArticle

Open Access
File
39 Citations (Scopus)
14 Downloads (Pure)

Obesity impairs muscle function and skeletal muscle extracellular matrix

Tam, C., Power, J., Markovic, T., Yee, C., Morsch, M., Mclennan, S. & Twigg, S., Jun 2015, In : Diabetes. 64, S1, p. A549-A549 1 p., 2150-P.

Research output: Contribution to journalMeeting abstract

The effects of high-fat feeding on physical function and skeletal muscle extracellular matrix

Tam, C. S., Power, J. E., Markovic, T. P., Yee, C., Morsch, M., McLennan, S. V. & Twigg, S. M., 14 Dec 2015, In : Nutrition and Diabetes. 5, p. 1-4 4 p., e187.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
3 Downloads (Pure)

The established and emerging roles of astrocytes and microglia in amyotrophic lateral sclerosis and frontotemporal dementia

Radford, R. A., Morsch, M., Rayner, S. L., Cole, N. J., Pountney, D. L. & Chung, R. S., 27 Oct 2015, In : Frontiers in Cellular Neuroscience. 9, p. 1-9 9 p., 414.

Research output: Contribution to journalReview article

Open Access
File
52 Citations (Scopus)
10 Downloads (Pure)
2014

Clinical and scientific aspects of muscle-specific tyrosine kinase-related myasthenia gravis

Reddel, S. W., Morsch, M. & Phillips, W. D., 1 Oct 2014, In : Current Opinion in Neurology. 27, 5, p. 558-565 8 p.

Research output: Contribution to journalReview article

21 Citations (Scopus)

Effects of the ß2-adrenoceptor agonist, albuterol, in a mouse model of anti-MuSK myasthenia gravis

Ghazanfari, N., Morsch, M., Tse, N., Reddel, S. W. & Phillips, W. D., 2014, In : PLoS ONE. 9, 2, p. 1-11 11 p., e87840.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Muscle-specific kinase (MuSK) autoantibodies suppress the MuSK pathway and ACh receptor retention at the mouse neuromuscular junction

Ghazanfari, N., Morsch, M., Reddel, S. W., Liang, S. X. & Phillips, W. D., 1 Jul 2014, In : Journal of Physiology. 592, 13, p. 2881-2897 17 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

The neuromuscular junction: measuring synapse size, fragmentation and changes in synaptic protein density using confocal fluorescence microscopy

Tse, N., Morsch, M., Ghazanfari, N., Cole, L., Visvanathan, A., Leamey, C. & Phillips, W. D., Dec 2014, In : Journal of visualized experiments : JoVE. 94, p. 1-16 16 p., e52220.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2013

Pyridostigmine but not 3,4-diaminopyridine exacerbates ACh receptor loss and myasthenia induced in mice by muscle-specific kinase autoantibody

Morsch, M., Reddel, S. W., Ghazanfari, N., Toyka, K. V. & Phillips, W. D., May 2013, In : Journal of Physiology. 591, 10, p. 2747-2762 16 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Sequence of Age-Associated Changes to the Mouse Neuromuscular Junction and the Protective Effects of Voluntary Exercise

Cheng, A., Morsch, M., Murata, Y., Ghazanfari, N., Reddel, S. W. & Phillips, W. D., 3 Jul 2013, In : PLoS ONE. 8, 7, p. 1-8 8 p., e67970.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2012

Muscle specific kinase autoantibodies cause synaptic failure through progressive wastage of postsynaptic acetylcholine receptors

Morsch, M., Reddel, S. W., Ghazanfari, N., Toyka, K. V. & Phillips, W. D., Oct 2012, In : Experimental Neurology. 237, 2, p. 286-295 10 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
2011

Muscle Specific Kinase: Organiser of synaptic membrane domains

Ghazanfari, N., Fernandez, K. J., Murata, Y., Morsch, M., Ngo, S. T., Reddel, S. W., Noakes, P. G. & Phillips, W. D., Mar 2011, In : International Journal of Biochemistry and Cell Biology. 43, 3, p. 295-298 4 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)
2009

Modulation of the Ca2+ conductance of nicotinic acetylcholine receptors by Lypd6

Darvas, M., Morsch, M., Racz, I., Ahmadi, S., Swandulla, D. & Zimmer, A., Sep 2009, In : European Neuropsychopharmacology. 19, 9, p. 670-681 12 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)