Mariana Brocardo

Dr

  • 463 Citations
  • 14 h-Index
19952016
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Research Outputs 1995 2016

  • 463 Citations
  • 14 h-Index
  • 17 Article
  • 2 Chapter
  • 2 Meeting abstract
  • 2 Review article
2016

APC binds the miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane

Mills, K. M., Brocardo, M. G. & Henderson, B. R., 1 Feb 2016, In : Molecular Biology of the Cell. 27, 3, p. 466-482 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Adenomatous Polyposis Coli
Mitochondria
Cell Membrane
Mutation
Kinesin

APC functions at the centrosome to stimulate microtubule growth

Lui, C., Ashton, C., Sharma, M., Brocardo, M. G. & Henderson, B. R., 1 Jan 2016, In : International Journal of Biochemistry and Cell Biology. 70, p. 39-47 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Centrosome
Adenomatous Polyposis Coli
Tubulin
Microtubules
Nucleation

Tankyrase inhibitors stimulate the ability of tankyrases to bind axin and drive assembly of β-catenin degradation-competent axin puncta

Martino-Echarri, E., Brocardo, M. G., Mills, K. M. & Henderson, B. R., 1 Mar 2016, In : PLoS ONE. 11, 3, p. 1-19 19 p., e0150484.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Tankyrases
beta Catenin
colorectal neoplasms
Degradation
degradation
2015

Rac1 augments Wnt signaling by stimulating β-catenin-lymphoid enhancer factor-1 complex assembly independent of β-catenin nuclear import

Jamieson, C., Lui, C., Brocardo, M. G., Martino-Echarri, E. & Henderson, B. R., 2015, In : Journal of Cell Science. 128, 21, p. 3933-3946 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
TCF Transcription Factors
Cell Nucleus Active Transport
beta Catenin
Transcriptional Activation
Ligation
2014

Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy

Martino-Echarri, E., Henderson, B. R. & Brocardo, M. G., 2014, In : Oncotarget. 5, 20, p. 9889-9900 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Adenomatous Polyposis Coli
DNA Replication
Fluorouracil
Colonic Neoplasms
Drug Therapy

Targeting the DNA replication checkpoint by pharmacologic inhibition of CHK1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy

Brocardo, M., Martino-Echarri, E. & Henderson, B. R., Nov 2014, In : Asia-Pacific Journal of Clinical Oncology. 10, p. 13-13 1 p.

Research output: Contribution to journalMeeting abstractResearch

The characterisation of APC localisation, dynamics and function at the centrosome

Lui, C., Sharma, M., Medina-Palazon, C., Mok, M. T. S., Brocardo, M. & Henderson, B. R., Nov 2014, In : Asia-Pacific Journal of Clinical Oncology. 10, S7, p. 36-36 1 p., P31.

Research output: Contribution to journalMeeting abstractResearch

Wnt signaling proteins associate with the nuclear pore complex: Implications for cancer

Sharma, M., Johnson, M., Brocardo, M., Jamieson, C. & Henderson, B. R., 2014, Cancer Biology and the Nuclear Envelope: Recent Advances May Elucidate Past Paradoxes. Schirmer, E. C. & de las Heras, J. I. (eds.). New York: Springer, Springer Nature, p. 353-372 20 p. (Advances in Experimental Medicine and Biology; vol. 773).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Wnt Proteins
Nuclear Pore Complex Proteins
Nuclear Pore
Nuclear Envelope
beta Catenin
2012

APC as a mobile scaffold: Regulation and function at the nucleus, centrosomes, and mitochondria

Lui, C., Mills, K., Brocardo, M. G., Sharma, M. & Henderson, B. R., Mar 2012, In : IUBMB Life. 64, 3, p. 209-214 6 p.

Research output: Contribution to journalReview articleResearchpeer-review

Centrosome
Adenomatous Polyposis Coli
Mitochondria
Scaffolds
Tumor Suppressor Proteins
2011

Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress

Brocardo, M. G., Borowiec, J. A. & Henderson, B. R., Sep 2011, In : International Journal of Biochemistry and Cell Biology. 43, 9, p. 1354-1364 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Adenomatous Polyposis Coli Protein
Replication Protein A
Adenomatous Polyposis Coli
DNA Replication
DNA

IQGAP1 translocates to the nucleus in early S-phase and contributes to cell cycle progression after DNA replication arrest

Johnson, M., Sharma, M., Brocardo, M. G. & Henderson, B. R., Jan 2011, In : International Journal of Biochemistry and Cell Biology. 43, 1, p. 65-73 9 p.

Research output: Contribution to journalArticleResearchpeer-review

DNA Replication
S Phase
Cell Cycle
Cells
DNA
2010

Nuclear export and centrosome targeting of the protein phosphatase 2A subunit B56α: Role of B56α in nuclear export of the catalytic subunit

Flegg, C. P., Sharma, M., Medina-Palazon, C., Jamieson, C., Galea, M., Brocardo, M. G., Mills, K. & Henderson, B. R., 11 Jun 2010, In : Journal of Biological Chemistry. 285, 24, p. 18144-18154 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein Phosphatase 2
Centrosome
Cell Nucleus Active Transport
Catalytic Domain
Protein Isoforms
2008

APC shuttling to the membrane, nucleus and beyond

Brocardo, M. & Henderson, B. R., Dec 2008, In : Trends in Cell Biology. 18, 12, p. 587-596 10 p.

Research output: Contribution to journalReview articleResearchpeer-review

Adenomatous Polyposis Coli
Membranes
Wnt Signaling Pathway
Neoplasms
M Phase Cell Cycle Checkpoints

Detection of cytoplasmic and nuclear localization of adenomatous polyposis coli (APC) protein in cells

Brocardo, M. & Henderson, B. R., 2008, Wnt signaling: Volume 1, Pathway Methods and Mammalian Models. Vincan, E. (ed.). New York: Humana Press, p. 77-89 13 p. (Methods in Molecular Biology; vol. 468).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Adenomatous Polyposis Coli Protein
Adenomatous Polyposis Coli
Antibody Specificity
Tumor Suppressor Genes
Colonic Neoplasms

Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: Regulation of Bcl-2 and implications for cell survival

Brocardo, M., Lei, Y., Tighe, A., Taylor, S. S., Mok, M. T. S. & Henderson, B. R., 29 Feb 2008, In : Journal of Biological Chemistry. 283, 9, p. 5950-5959 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Adenomatous Polyposis Coli Protein
Adenomatous Polyposis Coli
Mitochondria
Tumors
Cell Survival
2006

Membrane localization of adenomatous polyposis coli protein at cellular protrusions: Targeting sequences and regulation by β-catenin

Sharma, M., Leung, L., Brocardo, M., Henderson, J., Flegg, C. & Henderson, B. R., 23 Jun 2006, In : Journal of Biological Chemistry. 281, 25, p. 17140-17149 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Adenomatous Polyposis Coli Protein
Cell Surface Extensions
beta Catenin
Membranes
Protein Transport
2005

Redefining the subcellular location and transport of APC: New insights using a panel of antibodies

Brocardo, M., Näthke, I. S. & Henderson, B. R., 2005, In : EMBO Reports. 6, 2, p. 184-190 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Adenomatous Polyposis Coli
Fractionation
Tumors
Antibodies
Small Interfering RNA
2001

APC senses cell-cell contacts and moves to the nucleus upon their disruption

Brocardo, M. G., Bianchini, M., Radrizzani, M., Reyes, G. B., Dugour, A. V., Taminelli, G. L., Gonzalez Solveyra, C. & Santa-Coloma, T. A., 2001, In : Biochemical and Biophysical Research Communications. 284, 4, p. 982-986 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Tumor Suppressor Proteins
beta Catenin
Plating
Edetic Acid
Oligonucleotides

Early effects of insulin-like growth factor-1 in activated human T lymphocytes

Brocardo, M. G., Schillaci, R., Galeano, A., Radrizzani, M., White, V., González Guerrico, A., Santa-Coloma, T. A. & Roldán, A., 2001, In : Journal of Leukocyte Biology. 70, 2, p. 297-305 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Somatomedins
T-Lymphocytes
Interleukin-2
Phosphorylation
Somatomedin Receptors

Specific oligobodies against ERK-2 that recognize both the native and the denatured state of the protein

Bianchini, M., Radrizzani, M., Brocardo, M. G., Reyes, G. B., Gonzalez Solveyra, C. & Santa-Coloma, T. A., 1 Jun 2001, In : Journal of Immunological Methods. 252, 1-2, p. 191-197 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Oligonucleotides
Proteins
Immunoprecipitation
Western Blotting
Immunohistochemistry
2000

Development of monoclonal oligobodies and chemically synthesized oligobodies

Radrizzani, M., Brocardo, M. G., Solveyra, C. G., Bianchini, M., Reyes, G. B., Cafferata, E. G., Ortiz, G. V. & Santa-Coloma, T. A., 2000, In : Medicina. 60, SUPPL. 2, p. 55-60 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Oligonucleotides
Immunoprecipitation
Western Blotting
Immunohistochemistry
Proteins
1998

Downregulation of insulin-like growth factor-1 receptor (IGF-1R) expression in human T lymphocyte activation

Schillaci, R., Brocardo, M. G., Galeano, A. & Roldán, A., 1 Feb 1998, In : Cellular Immunology. 183, 2, p. 157-161 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Somatomedin Receptors
Lymphocyte Activation
Down-Regulation
T-Lymphocytes
Insulin-Like Growth Factor I
1995

Co‐operative effect between insulin‐like growth factor‐1 and interleukin‐2 on DNA synthesis and interleukin‐2 receptor‐α chain expression in human lymphocytes

SCHILLACI, ROXANA., BROCARDO, MARIANA. G. & ROLDAN, ALICIA., 1995, In : Immunology and Cell Biology. 73, 4, p. 340-345 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Interleukin-2 Receptor alpha Subunit
Somatomedins
Interleukin-2
Lymphocytes
Insulin-Like Growth Factor I