Mariana Brocardo

Dr

  • 464 Citations
  • 14 h-Index
19952016
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Research Outputs 1995 2016

  • 464 Citations
  • 14 h-Index
  • 17 Article
  • 2 Chapter
  • 2 Meeting abstract
  • 2 Review article
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Article

Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress

Brocardo, M. G., Borowiec, J. A. & Henderson, B. R., Sep 2011, In : International Journal of Biochemistry and Cell Biology. 43, 9, p. 1354-1364 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Adenomatous Polyposis Coli Protein
Replication Protein A
Adenomatous Polyposis Coli
DNA Replication
DNA

APC binds the miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane

Mills, K. M., Brocardo, M. G. & Henderson, B. R., 1 Feb 2016, In : Molecular Biology of the Cell. 27, 3, p. 466-482 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Adenomatous Polyposis Coli
Mitochondria
Cell Membrane
Mutation
Kinesin

APC functions at the centrosome to stimulate microtubule growth

Lui, C., Ashton, C., Sharma, M., Brocardo, M. G. & Henderson, B. R., 1 Jan 2016, In : International Journal of Biochemistry and Cell Biology. 70, p. 39-47 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Centrosome
Adenomatous Polyposis Coli
Tubulin
Microtubules
Nucleation

APC senses cell-cell contacts and moves to the nucleus upon their disruption

Brocardo, M. G., Bianchini, M., Radrizzani, M., Reyes, G. B., Dugour, A. V., Taminelli, G. L., Gonzalez Solveyra, C. & Santa-Coloma, T. A., 2001, In : Biochemical and Biophysical Research Communications. 284, 4, p. 982-986 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Tumor Suppressor Proteins
beta Catenin
Plating
Edetic Acid
Oligonucleotides

Co‐operative effect between insulin‐like growth factor‐1 and interleukin‐2 on DNA synthesis and interleukin‐2 receptor‐α chain expression in human lymphocytes

SCHILLACI, ROXANA., BROCARDO, MARIANA. G. & ROLDAN, ALICIA., 1995, In : Immunology and Cell Biology. 73, 4, p. 340-345 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Interleukin-2 Receptor alpha Subunit
Somatomedins
Interleukin-2
Lymphocytes
Insulin-Like Growth Factor I

Development of monoclonal oligobodies and chemically synthesized oligobodies

Radrizzani, M., Brocardo, M. G., Solveyra, C. G., Bianchini, M., Reyes, G. B., Cafferata, E. G., Ortiz, G. V. & Santa-Coloma, T. A., 2000, In : Medicina. 60, SUPPL. 2, p. 55-60 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Oligonucleotides
Immunoprecipitation
Western Blotting
Immunohistochemistry
Proteins

Downregulation of insulin-like growth factor-1 receptor (IGF-1R) expression in human T lymphocyte activation

Schillaci, R., Brocardo, M. G., Galeano, A. & Roldán, A., 1 Feb 1998, In : Cellular Immunology. 183, 2, p. 157-161 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Somatomedin Receptors
Lymphocyte Activation
Down-Regulation
T-Lymphocytes
Insulin-Like Growth Factor I

Early effects of insulin-like growth factor-1 in activated human T lymphocytes

Brocardo, M. G., Schillaci, R., Galeano, A., Radrizzani, M., White, V., González Guerrico, A., Santa-Coloma, T. A. & Roldán, A., 2001, In : Journal of Leukocyte Biology. 70, 2, p. 297-305 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Somatomedins
T-Lymphocytes
Interleukin-2
Phosphorylation
Somatomedin Receptors

IQGAP1 translocates to the nucleus in early S-phase and contributes to cell cycle progression after DNA replication arrest

Johnson, M., Sharma, M., Brocardo, M. G. & Henderson, B. R., Jan 2011, In : International Journal of Biochemistry and Cell Biology. 43, 1, p. 65-73 9 p.

Research output: Contribution to journalArticleResearchpeer-review

DNA Replication
S Phase
Cell Cycle
Cells
DNA

Membrane localization of adenomatous polyposis coli protein at cellular protrusions: Targeting sequences and regulation by β-catenin

Sharma, M., Leung, L., Brocardo, M., Henderson, J., Flegg, C. & Henderson, B. R., 23 Jun 2006, In : Journal of Biological Chemistry. 281, 25, p. 17140-17149 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Adenomatous Polyposis Coli Protein
Cell Surface Extensions
beta Catenin
Membranes
Protein Transport

Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: Regulation of Bcl-2 and implications for cell survival

Brocardo, M., Lei, Y., Tighe, A., Taylor, S. S., Mok, M. T. S. & Henderson, B. R., 29 Feb 2008, In : Journal of Biological Chemistry. 283, 9, p. 5950-5959 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Adenomatous Polyposis Coli Protein
Adenomatous Polyposis Coli
Mitochondria
Tumors
Cell Survival

Nuclear export and centrosome targeting of the protein phosphatase 2A subunit B56α: Role of B56α in nuclear export of the catalytic subunit

Flegg, C. P., Sharma, M., Medina-Palazon, C., Jamieson, C., Galea, M., Brocardo, M. G., Mills, K. & Henderson, B. R., 11 Jun 2010, In : Journal of Biological Chemistry. 285, 24, p. 18144-18154 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein Phosphatase 2
Centrosome
Cell Nucleus Active Transport
Catalytic Domain
Protein Isoforms

Rac1 augments Wnt signaling by stimulating β-catenin-lymphoid enhancer factor-1 complex assembly independent of β-catenin nuclear import

Jamieson, C., Lui, C., Brocardo, M. G., Martino-Echarri, E. & Henderson, B. R., 1 Nov 2015, In : Journal of Cell Science. 128, 21, p. 3933-3946 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
TCF Transcription Factors
Cell Nucleus Active Transport
beta Catenin
Transcriptional Activation
Ligation

Redefining the subcellular location and transport of APC: New insights using a panel of antibodies

Brocardo, M., Näthke, I. S. & Henderson, B. R., 2005, In : EMBO Reports. 6, 2, p. 184-190 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Adenomatous Polyposis Coli
Fractionation
Tumors
Antibodies
Small Interfering RNA

Specific oligobodies against ERK-2 that recognize both the native and the denatured state of the protein

Bianchini, M., Radrizzani, M., Brocardo, M. G., Reyes, G. B., Gonzalez Solveyra, C. & Santa-Coloma, T. A., 1 Jun 2001, In : Journal of Immunological Methods. 252, 1-2, p. 191-197 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Oligonucleotides
Proteins
Immunoprecipitation
Western Blotting
Immunohistochemistry

Tankyrase inhibitors stimulate the ability of tankyrases to bind axin and drive assembly of β-catenin degradation-competent axin puncta

Martino-Echarri, E., Brocardo, M. G., Mills, K. M. & Henderson, B. R., 1 Mar 2016, In : PLoS ONE. 11, 3, p. 1-19 19 p., e0150484.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Tankyrases
beta Catenin
colorectal neoplasms
Degradation
degradation

Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy

Martino-Echarri, E., Henderson, B. R. & Brocardo, M. G., 2014, In : Oncotarget. 5, 20, p. 9889-9900 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Adenomatous Polyposis Coli
DNA Replication
Fluorouracil
Colonic Neoplasms
Drug Therapy