Mark Connor

Professor

  • 4513 Citations
  • 39 h-Index
1991 …2019
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Personal profile

Biography

I am Pharmacologist interested in analgesics and other psychoactive drugs, particularly cannabinoids and opioids. My lab studies how opioids, cannabinoids and related molecules interact with G protein coupled receptors and ion channels to exert their effects. Currently my work is focussed on how clinically used opioids interact with naturally occuring variants of human opioid receptors, the pharmacology and toxicity of emerging synthetic cannabinoid receptors agonists (Spice/K2) and the molecular mechanisms underlying the potential therapeutic actions of cannabis and its components.

Education/Academic qualification

Pharmacology, PhD, University of Washington

Pharmacology, Genetics, BSc (Hons), University of Sydney

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Projects 2008 2019

Research Output 1991 2019

Regulation of heterologously expressed 5-HT1B receptors coupling to potassium channels in AtT-20 cells

Heblinski, M., Bladen, C. & Connor, M., 1 Feb 2019, In : British Journal of Pharmacology. 176, 3, p. 451-465 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Receptor, Serotonin, 5-HT1B
Potassium Channels
Sumatriptan
Serotonin
G Protein-Coupled Inwardly-Rectifying Potassium Channels

Synthesis and pharmacology of new psychoactive substance 5F-CUMYL-P7AICA, a scaffold- hopping analog of synthetic cannabinoid receptor agonists 5F-CUMYL-PICA and 5F-CUMYL-PINACA

Banister, S. D., Adams, A., Kevin, R. C., Macdonald, C., Glass, M., Boyd, R., Connor, M., McGregor, I. S., Havel, C. M., Bright, S. J., Vilamala, M. V., Lladanosa, C. G., Barratt, M. J. & Gerona, R. R., Feb 2019, In : Drug Testing and Analysis. 11, 2, p. 279-291 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Artificial Receptors
Cannabinoid Receptor Agonists
Scaffolds
nuclear magnetic resonance
liquid chromatography

Conformationally rigid derivatives of WAY-267,464: synthesis and pharmacology at the human oxytocin and vasopressin-1a receptors

Jorgensen, W. T., Gulliver, D. W., Katte, T. A., Werry, E. L., Reekie, T. A., Connor, M. & Kassiou, M., 1 Jan 2018, In : European Journal of Medicinal Chemistry. 143, p. 1644-1656 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Oxytocin Receptors
Vasopressin Receptors
Oxytocin
Vasopressins
Assays

The chemistry and pharmacology of synthetic cannabinoid SDB-006 and its regioisomeric fluorinated and methoxylated analogs

Banister, S. D., Olson, A., Winchester, M., Stuart, J., Edington, A. R., Kevin, R. C., Longworth, M., Herrera, M., Connor, M., Mcgregor, I. S., Gerona, R. R. & Kassiou, M., Jul 2018, In : Drug Testing and Analysis. 10, 7, p. 1099-1109 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Cannabinoids
fluorine
Fluorine
biotelemetry
Pharmacology

The potentiating effect of calcitonin gene-related peptide on transient receptor potential vanilloid-1 activity and the electrophysiological responses of rat trigeminal neurons to nociceptive stimuli

Chatchaisak, D., Connor, M., Srikiatkhachorn, A. & Chetsawang, B., May 2018, In : Journal of Physiological Sciences. 68, 3, p. 261–268 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Nociceptors
Calcitonin Gene-Related Peptide
Trigeminal Ganglion
Organ Culture Techniques
Capsaicin