Projects per year
Personal profile
Biography
I am Pharmacologist interested in analgesics and other psychoactive drugs, particularly cannabinoids and opioids. My lab studies how opioids, cannabinoids and related molecules interact with G protein coupled receptors and ion channels to exert their effects. Currently my work is focussed on how clinically used opioids interact with naturally occuring variants of human opioid receptors, the pharmacology and toxicity of emerging synthetic cannabinoid receptors agonists (Spice/K2) and the molecular mechanisms underlying the potential therapeutic actions of cannabis and its components.
Education/Academic qualification
Pharmacology, PhD, University of Washington (UW)
Pharmacology, Genetics, BSc (Hons), University of Sydney
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Projects
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Development of next-generation targeted therapies for epilepsy and pain based on cannabinoid derivatives
Bladen, C. & Connor, M.
3/07/17 → …
Project: Research
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Advanced protein quantification capability
Walker, A. K., Lee, A., Connor, M., Atkin, J., Lim, E., Baker, M. S., Rizos, H., Phillips, J. K., Yang, S. & Blair, I.
1/01/17 → …
Project: Research
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Mechanisms underlying the repellent effects of predator odours in rodents
Connor, M., McGregor, I., Crowther, M. & Banister, S.
1/01/16 → …
Project: Research
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The pharmacology and toxicity of synthetic cannabinoids
Connor, M., Kassiou, M. & McGregor, I.
1/01/16 → …
Project: Research
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Establishment of archival freezer storage bay
Chung, R., Atkin, J., Connor, M., Blair, I., Rizos, H., Phillips, J. K. & Laird, A.
1/01/19 → 31/12/19
Project: Research
Research Outputs
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Differential activation of G protein-mediated signaling by synthetic cannabinoid receptor agonists
Sachdev, S., Banister, S. D., Santiago, M., Bladen, C., Kassiou, M. & Connor, M., 1 Apr 2020, In : Pharmacology Research & Perspectives. 8, 2, p. 1-10 10 p., e00566.Research output: Contribution to journal › Article
Open AccessFile3 Citations (Scopus)7 Downloads (Pure) -
Exploring stereochemical and conformational requirements at cannabinoid receptors for synthetic cannabinoids related to SDB-006, 5F-SDB-006, CUMYL-PICA, and 5F-CUMYL-PICA
Ametovski, A., Macdonald, C., Manning, J. J., Haneef, S. A. S., Santiago, M., Martin, L., Sparkes, E., Reckers, A., Gerona, R. R., Connor, M., Glass, M. & Banister, S. D., 4 Nov 2020, In : ACS Chemical Neuroscience. 11, 21, p. 3672-3682 11 p.Research output: Contribution to journal › Article
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Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists
Gillis, A., Gondin, A. B., Kliewer, A., Sanchez, J., Lim, H. D., Alamein, C., Manandhar, P., Santiago, M., Fritzwanker, S., Schmidel, F., Katte, T. A., Reekie, T., Grimsey, N. L., Kassiou, M., Kellam, B., Krasel, C., Halls, M. L., Connor, M., Lane, J. R., Schulz, S. & 2 others, , 31 Mar 2020, In : Science Signaling. 13, 625, p. 1-18 18 p., eaaz3140.Research output: Contribution to journal › Article
19 Citations (Scopus) -
Terpenoids commonly found in Cannabis sativa do not modulate the actions of phytocannabinoids or endocannabinoids on TRPA1 and TRPV1 channels
Heblinski, M., Santiago, M., Fletcher, C., Stuart, J., Connor, M., McGregor, I. S. & Arnold, J. C., 9 Mar 2020, In : Cannabis and Cannabinoid Research. 13 p.Research output: Contribution to journal › Article
Open Access -
Absence of entourage: terpenoids commonly found in Cannabis sativa do not modulate the functional activity of Δ9-THC at human CB1 and CB2 receptors
Santiago, M., Sachdev, S., Arnold, J. C., McGregor, I. & Connor, M., 1 Sep 2019, In : Cannabis and Cannabinoid Research. 4, 3, p. 165-176 12 p.Research output: Contribution to journal › Article
Open AccessFile14 Citations (Scopus)12 Downloads (Pure)