Projects per year
Personal profile
Biography
Profesor Mark Molloy’s expertise is centred on the development and application of proteomic analyses for addressing problems in the life-sciences. His expertise in the use of mass spectrometry as the core analytical technique supports collaborative research in many science and biomedical areas, where he has a particularly strong focus towards translational cancer research. A major theme has been development of new mass spectrometry workflows for quantitative targeted proteomic analyses. This has enabled investigation of important questions such as the molecular characterisation of colon, thyroid and pancreatic cancers, melanomas and some lung cancers. The information has been used to identify prognostic and predictive protein biomarkers. More recently, he has opened a new research direction to use high resolution mass spectrometry for pharmacokinetic monitoring of cancer drug levels in cancer patients and is explore analysis from dried blood spots.
Mark’s leadership and international standing in the application of proteomics is evidenced by outstanding grant success (career total $42.9M), publications (>150), Scopus citations (>5,000) and HDR student completions (14). He was Director of the Australian Proteome Analysis Facility 2010-18 where his team provided expertise and world-class proteomic infrastructure to ~100 external academic and industry end-users each year.
Mark completed his PhD in proteomic sciences at Macquarie University under the supervision of Keith Williams before conducting post-doctoral research at the University of Michigan Medical School in Ann Arbor, USA. He then worked in the US pharmaceutical industry at Pfizer Inc for four years. He returned to Australia to carry out a National Health and Medical Research Council career development award fellowship on colorectal cancer (CRC) biomarker proteins before becoming Director of APAF.
He is an Honorary Professor in the Department of Molecular Sciences and Professor at The University of Sydney.
External positions
Professor, University of Sydney
Mar 2018 → …
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Collaborations and top research areas from the last five years
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High content oncoproteomics for improved prognostication and treatment response
Packer, N., Molloy, M., Engel, A., Clarke, S., Gill, A., Samra, J., Baker, M. S. & Thaysen-Andersen, M.
1/07/17 → …
Project: Research
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Blood biomarkers for the diagnosis of pre-clinical Alzheimer¿s disease employing the Dominantly Inherited Alzheimer Network cohort
Molloy, M., Martins, R., Fagan, A., Wenk, M., Multhaup, G., Xiong, C. & Chatterjee, P.
1/01/17 → …
Project: Research
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Understanding the early disease mechanisms of motor neuron disease and frontotemporal dementia
Walker, A. K., Bye, C., Halliday, G., Atkin, J., Molloy, M. & Lee, V.
1/01/17 → …
Project: Research
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Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria
Mu, A., Klare, W. P., Baines, S. L., Ignatius Pang, C. N., Guérillot, R., Harbison-Price, N., Keller, N., Wilksch, J., Nhu, N. T. K., Phan, M-D., Keller, B., Nijagal, B., Tull, D., Dayalan, S., Chua, H. H. C., Skoneczny, D., Koval, J., Hachani, A., Shah, A. D., Neha, N., & 71 others , 18 Mar 2023, In: Nature Communications. 14, 1, p. 1-21 21 p., 1530.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)4 Downloads (Pure) -
Plasma Aβ42/40 ratio, p-tau181, GFAP and NFL across the Alzheimer’s disease continuum: a cross-sectional and longitudinal study in the AIBL cohort
Chatterjee, P., Pedrini, S., Doecke, J. D., Thota, R., Villemagne, V. L., Dore, V., Singh, A. K., Wang, P., Rainey-Smith, S., Fowler, C., Taddei, K., Sohrabi, H. R., Molloy, M. P., Ames, D., Maruff, P., Rowe, C. C., Masters, C. L., Martins, R. N. & The AIBL Research Group, Apr 2023, In: Alzheimer's and Dementia. 19, 4, p. 1117-1134 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)12 Downloads (Pure) -
Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer's disease: associations with Aβ-PET, neurodegeneration, and cognition
Chatterjee, P., Vermunt, L., Gordon, B. A., Pedrini, S., Boonkamp, L., Armstrong, N. J., Xiong, C., Singh, A. K., Li, Y., Sohrabi, H. R., Taddei, K., Molloy, M., Benzinger, T. L. S., Morris, J. C., Karch, C., Berman, S., Chhatwal, J., Cruchaga, C., Graff-Radford, N. R., Day, G. S., & 19 others , Jul 2023, In: Alzheimer's and Dementia. 19, 7, p. 2790-2804 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)5 Downloads (Pure) -
One step forward with dry surface biofilm (DSB) of Staphylococcus aureus: TMT-based quantitative proteomic analysis reveals proteomic shifts between DSB and hydrated biofilm
Rahman, M. A., Amirkhani, A., Parvin, F., Chowdhury, D., Molloy, M. P., Deva, A. K., Vickery, K. & Hu, H., 13 Oct 2022, In: International Journal of Molecular Sciences. 23, 20, p. 1-17 17 p., 12238.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)5 Downloads (Pure) -
Overlapping genes in natural and engineered genomes
Wright, B. W., Molloy, M. P. & Jaschke, P. R., Mar 2022, In: Nature Reviews Genetics. 23, 3, p. 154-168 15 p.Research output: Contribution to journal › Review article › peer-review
27 Citations (Scopus)