Projects per year
Personal profile
Biography
Natalie is a Postdoctoral Research Fellow in the Genomics and Bioinformatics Team within the multidisciplinary Motor Neuron Disease (MND) Research Centre at Macquarie University.
She was awarded a Bachelor of Science (Advanced) (Honours I) majoring in Biochemistry and Immunology from the University of Sydney in 2017. Natalie joined the MND Research Centre in 2018 as a Research Assistant for the Genetics and Genomics Team where she conducted a range of molecular and cell biology techniques to characterise MND-associated genetic variants. She commenced her PhD studies in 2021, which focused on understanding the molecular basis of sporadic MND by application of genomic and transcriptomic techniques to patient-derived biospecimens. Natalie’s current research is focused on characterising the MND brain transcriptome utilising cutting-edge RNA sequencing techniques.
Education/Academic qualification
PhD, Macquarie University
Award Date: 27 Feb 2025
BSc (Adv) (Honours I), University of Sydney
Award Date: 1 May 2018
External positions
Research Residency, University of Graz
Oct 2023 → Dec 2023
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Collaborations and top research areas from the last five years
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FightMND IMPACT: Developing novel gene expression control mechanisms for ALS gene therapies
Chung, R. (Primary Chief Investigator), Williams, K. (Chief Investigator), Grima, N. (Chief Investigator) & Chapman, T. (Chief Investigator)
1/03/24 → 1/03/26
Project: Research
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FightMND Discovery: Deciphering the role of TDP43 regulation of cryptic exons in ALS pathogenesis
Chung, R. (Primary Chief Investigator), Williams, K. (Chief Investigator), Lee, A. (Chief Investigator), Morsch, M. (Chief Investigator), Rayner, S. (Chief Investigator) & Grima, N. (Chief Investigator)
1/10/23 → 30/09/26
Project: Research
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MND 24: Investigating the molecular origin of a “C9orf72-like” patient subgroup of sporadic ALS
Grima, N. (Primary Chief Investigator), Henden, L. (Chief Investigator) & Williams, K. (Chief Investigator)
1/01/25 → 31/12/25
Project: Research
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MNDRA PhD Top-Up Scholarship: Investigating novel genomic and transcriptomic features of sporadic MND
Blair, I. (Primary Chief Investigator), Williams, K. (Supervisor) & Grima, N. (Student)
1/04/21 → 31/03/24
Project: Research
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FightMND PhD Scholarship: Investigating novel genomic and transcriptomic features of sporadic MND
Blair, I. (Primary Chief Investigator), Williams, K. (Chief Investigator) & Grima, N. (PhD Student)
1/04/21 → 30/09/24
Project: Research
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Genetic characterisation of ATXN2 in Australian amyotrophic lateral sclerosis
Wu, S. S. L., McCann, E. P., Chan Moi Fat, S., Grima, N., Henden, L., Fearnley, L. G., Chiu, P., Williams, K. L., Rowe, D. B., Nicholson, G. A., Kiernan, M. C., Blair, I. P., Yang, S. & Fifita, J. A., Mar 2026, In: Brain Disorders. 21, p. 1-9 9 p., 100301.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement
Grima, N., Smith, A. N., Shepherd, C. E., Henden, L., Winn, T., Carroll, L., Rowe, D. B., Kiernan, M. C., Blair, I. P. & Williams, K. L., 25 Apr 2025, In: Molecular Neurodegeneration. 20, 1, p. 1-19 19 p., 40.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)29 Downloads (Pure) -
Integration is the foundation for discovery: Macquarie Neurodegenerative Diseases Biobank
Zussa, Z. N., Heads, J. A., Henden, L., Grima, N., D'Silva, S., Poynter, D., Rowe, D. B., Blair, I. P. & Williams, K. L., 2024, (Unpublished). 1 p.Research output: Contribution to conference › Poster
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Characterising the genetic landscape of amyotrophic lateral sclerosis: a catalogue and assessment of over 1,000 published genetic variants
McCann, E. P., Grima, N., Fifita, J. A., Chan Moi Fat, S., Lehnert, K., Henden, L., Blair, I. P. & Williams, K. L., 7 Nov 2023, In: Journal of Neuromuscular Diseases. 10, 6, p. 1127-1141 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)61 Downloads (Pure) -
RNA sequencing of peripheral blood in amyotrophic lateral sclerosis reveals distinct molecular subtypes: considerations for biomarker discovery
Grima, N., Liu, S., Southwood, D., Henden, L., Smith, A., Lee, A., Rowe, D. B., D'Silva, S., Blair, I. P. & Williams, K. L., Dec 2023, In: Neuropathology and Applied Neurobiology. 49, 6, p. 1-16 16 p., e12943.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)131 Downloads (Pure)
Prizes
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Society for Neuroscience Trainee Professional Development Award
Grima, N. (Recipient), 22 Sept 2022
Prize
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