Projects per year
Personal profile
Research interests
We now know that sugars attached to proteins and lipids on every cell (glycans) are intricately involved in bacterial and viral infection, the immune responses (both innate and acquired), all cancers, lung disease, brain function, fertilisation, cardiovascular disease and a multitude of other cellular mechanisms in human and all other species. My objective is to increase the scientific research activity in this field so that beneficial improvements to our biological understanding, and ultimately treatment, of health and disease can be achieved. To implement my objective, I have spent the last almost 30 years or so (with some time out to rear three children) applying my knowledge and leadership skills to achieve this implementation.
Biography
Prof Nicki Packer has had an extensive and varied career in biochemical research in both Chemistry and Biological Sciences. She was part of the team that established the Australian Proteome Analysis Facility (APAF) and co-founded Proteome Systems Limited, an Australian biotechnology company in which her group developed a platform of glycoanalytical technology and informatics tools. She is now Distinguished Professor of Glycoproteomics, Deputy Director of the MQ Biomolecular Discovery Research Centre and Academic Lead of APAF at Macquarie University, Sydney, Australia. She is a Chief Investigator in the ARC Centre of Excellence in Nanoscale Biophotonics and in the ARC Centre of Excellence in Synthetic Biology. She has gained international and national profile by linking glycomics with the proteomics and bioinformatics approaches to biological functional research. Her research interests are now in the structure, function, informatics and application of glycans and their conjugates as molecular markers, particularly in their role in cancer, therapeutics and microbial infection. Nicki has published extensively on glycomics research and works closely with industry.
Education/Academic qualification
Biochemistry, PhD, University of Sydney
1 Jan 1973 → 31 Dec 1977
Award Date: 31 Mar 1978
External positions
Principal Research Leader, Institute for Glycomics
1 Jan 2017 → 31 Dec 2021
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Collaborations and top research areas from the last five years
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A Prelude towards transforming adenoid cystic carcinoma into an immune hot tumour
Chakraborty, R., Packer, N., Shannon, K., Rizos, H., Lee, J., Nasiri, N., Dawes, J., Tay, A. & Surya, V.
1/01/25 → 30/06/26
Project: Research
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LE24: Integrated multimodal microscopy facility for single molecule analysis
Wang, Y., Rodger, A., Packer, N., Jiang, Y., Tricoli, A., Chu, D., Care, A., Della Gaspera, E., Hong, Y., Goldys, E., Elbourne, A. & Garcia-Bennett, A.
12/06/24 → 11/06/25
Project: Research
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GalSIC: GlySpace Alliance: Data Resources for Glycoscience
Packer, N., Lisacek, F. & Tiemeyer, M.
1/04/24 → 31/03/25
Project: Research
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IDEAS: Metformin, gut epithelium and microbiome in the prevention of colorectal cancer
Packer, N., Molloy, M., Hewawasam Gamage, H., Paulsen, I., Engel, A. & El-Omar, E.
1/07/23 → 30/06/26
Project: Research
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Precision monitoring of reproductive state via development of pen side mucus testing and continuous remote monitoring Project 6A-106a
Verma, P. J., Bathgate, R., Packer, N., D'Souza, D., Dunning, K., Plush, K., Weaver, A., Glencorse, D. & Nowland, T.
1/04/23 → 31/03/25
Project: Research
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Deletion of the asialyloglycoprotein receptor-1 (ASGR1) causes atheroprotective effects in vitro and in vivo
Bursill, C., Pullen, B. J., Debebe, D., Sandeman, L., Wattchow, N. E., Vidanapathirana, A., Stretton, L., Nicholls, S. J., Chen, Y. C., Peter, K., Nankivell, V. A., Blake, S., Tan, J. T. M., Psaltis, P. J. & Packer, N. H., 28 Oct 2024, In: European Heart Journal. 45, Suppl 1, 1 p., ehae6663875.Research output: Contribution to journal › Meeting abstract › peer-review
Open Access -
Experimentally determined diagnostic ions for identification of peptide glycotopes
DeBono, N. J., Moh, E. S. X. & Packer, N. H., 18 Jun 2024, (E-pub ahead of print) In: Journal of Proteome Research.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Lectin-conjugated nanotags with high SERS stability: selective probes for glycans
Tavakkoli Yaraki, M., Wongtrakul-Kish, K., Moh, E., Packer, N. & Wang, Y., 21 Mar 2024, In: Analyst. 149, 6, p. 1774-1783 10 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
Pathogenic hypothalamic extracellular matrix promotes metabolic disease
Beddows, C., Shi, F., Horton, A., Dalal, S., Zhang, P., Ling, C-C., Yong, V. W., Loh, K., Cho, E., Karagiannis, C., Rose, A., Montgomery, M. K., Gregorevic, P., Watt, M., Packer, N. H., Parker, B. L., Brown, R. M., Moh, E. & Dodd, G. T., 26 Sept 2024, In: Nature. 633, 8031, p. 914-922 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)5 Downloads (Pure) -
Quantitative subcellular reconstruction reveals a lipid mediated inter-organelle biogenesis network
Lee, R. G., Rudler, D. L., Raven, S. A., Peng, L., Chopin, A., Moh, E. S. X., McCubbin, T., Siira, S. J., Fagan, S. V., DeBono, N. J., Stentenbach, M., Browne, J., Rackham, F. F., Li, J., Simpson, K. J., Marcellin, E., Packer, N. H., Reid, G. E., Padman, B. S., Rackham, O., & 1 others , Jan 2024, In: Nature Cell Biology. 26, 1, p. 57-71 42 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus)