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Personal profile

Research interests

We now know that sugars attached to proteins and lipids on every cell (glycans) are intricately involved in bacterial and viral infection, the immune responses (both innate and acquired), all cancers, lung disease, brain function, fertilisation, cardiovascular disease and a multitude of other cellular mechanisms in human and all other species. My objective is to increase the scientific research activity in this field so that beneficial improvements to our biological understanding, and ultimately treatment, of health and disease can be achieved. To implement my objective, I have spent the last almost 30 years or so (with some time out to rear three children) applying my knowledge and leadership skills to achieve this implementation.

Biography

Prof Nicki Packer has had an extensive and varied career in biochemical research in both Chemistry and Biological Sciences. She was part of the team that established the Australian Proteome Analysis Facility (APAF) and co-founded Proteome Systems Limited, an Australian biotechnology company in which her group developed a platform of glycoanalytical technology and informatics tools. She is now Professor of Glycoproteomics, Director of the MQ Biomolecular Discovery & Design Research Centre and Consultant to APAF at Macquarie University, Sydney, Australia. She has gained international and national profile by linking glycomics with the proteomics and bioinformatics approaches to biological functional research. Her research interests are now in the structure, function, informatics and application of glycans and their conjugates as molecular markers, particularly in their role in cancer, therapeutics and microbial infection. Nicki has published extensively on glycomics research and works closely with industry.

Education/Academic qualification

Biochemistry, PhD, University of Sydney

1 Jan 197331 Dec 1977

External positions

Principal Research Leader, Institute for Glycomics

1 Jan 201731 Dec 2021

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Projects 2006 2020

Research Output 1977 2019

Differential involvement of glycans in the binding of Staphylococcus epidermidis and Corynebacterium spp. to human sweat

Lin, C-H., Peterson, R. A., Gueniche, A., de Beaumais, S. A., Hourblin, V., Breton, L., Dalko, M. & Packer, N. H., Mar 2019, In : Microbiological Research. 220, p. 53-60 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Corynebacterium
Staphylococcus epidermidis
Sweat
Polysaccharides
Fucose

GlyConnect: glycoproteomics goes visual, interactive, and analytical

Alocci, D., Mariethoz, J., Gastaldello, A., Gasteiger, E., Karlsson, N. G., Kolarich, D., Packer, N. H. & Lisacek, F., 2019, In : Journal of Proteome Research. 18, 2, p. 664-677 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Glycomics
Glycosylation
Bioinformatics
Genomics
Computational Biology

Understanding cellular glycan surfaces in the central nervous system

Iqbal, S., Ghanimi Fard, M., Everest-Dass, A., Packer, N. H. & Parker, L. M., 28 Feb 2019, In : Biochemical Society Transactions. 47, 1, p. 89-100 12 p.

Research output: Contribution to journalReview articleResearchpeer-review

Neurology
Polysaccharides
Central Nervous System
Brain
Brain Neoplasms

Biosimilarity and interchangeability: principles and evidence: a systematic review

McKinnon, R. A., Cook, M., Liauw, W., Marabani, M., Marschner, I. C., Packer, N. H. & Prins, J. B., Feb 2018, In : BioDrugs. 32, 1, p. 27-52 26 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Biosimilar Pharmaceuticals
Safety
Biological Products
Pharmacovigilance
PubMed

Building a PGC-LC-MS N-glycan retention library and elution mapping resource

Abrahams, J. L., Campbell, M. P. & Packer, N. H., Feb 2018, In : Glycoconjugate Journal. 35, 1, p. 15-29 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Liquid chromatography
Liquid Chromatography
Libraries
Mass spectrometry
Polysaccharides