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Personal profile

Research interests

We now know that sugars attached to proteins and lipids on every cell (glycans) are intricately involved in bacterial and viral infection, the immune responses (both innate and acquired), all cancers, lung disease, brain function, fertilisation, cardiovascular disease and a multitude of other cellular mechanisms in human and all other species. My objective is to increase the scientific research activity in this field so that beneficial improvements to our biological understanding, and ultimately treatment, of health and disease can be achieved. To implement my objective, I have spent the last almost 30 years or so (with some time out to rear three children) applying my knowledge and leadership skills to achieve this implementation.

Biography

Prof Nicki Packer has had an extensive and varied career in biochemical research in both Chemistry and Biological Sciences. She was part of the team that established the Australian Proteome Analysis Facility (APAF) and co-founded Proteome Systems Limited, an Australian biotechnology company in which her group developed a platform of glycoanalytical technology and informatics tools. She is now Professor of Glycoproteomics, Director of the MQ Biomolecular Discovery & Design Research Centre and Consultant to APAF at Macquarie University, Sydney, Australia. She has gained international and national profile by linking glycomics with the proteomics and bioinformatics approaches to biological functional research. Her research interests are now in the structure, function, informatics and application of glycans and their conjugates as molecular markers, particularly in their role in cancer, therapeutics and microbial infection. Nicki has published extensively on glycomics research and works closely with industry.

Education/Academic qualification

Biochemistry, PhD, University of Sydney

1 Jan 197331 Dec 1977

External positions

Principal Research Leader, Institute for Glycomics

1 Jan 201731 Dec 2021

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Glycosylation Chemical Compounds
Polysaccharides Medicine & Life Sciences
Glycomics Medicine & Life Sciences
Glycoproteins Medicine & Life Sciences
Proteins Chemical Compounds
Mass spectrometry Chemical Compounds
Oligosaccharides Chemical Compounds
Glycopeptides Chemical Compounds

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Projects 2006 2020

Research Outputs 1977 2019

Differential involvement of glycans in the binding of Staphylococcus epidermidis and Corynebacterium spp. to human sweat

Lin, C-H., Peterson, R. A., Gueniche, A., de Beaumais, S. A., Hourblin, V., Breton, L., Dalko, M. & Packer, N. H., Mar 2019, In : Microbiological Research. 220, p. 53-60 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Corynebacterium
Staphylococcus epidermidis
Sweat
Polysaccharides
Fucose

GlyConnect: glycoproteomics goes visual, interactive, and analytical

Alocci, D., Mariethoz, J., Gastaldello, A., Gasteiger, E., Karlsson, N. G., Kolarich, D., Packer, N. H. & Lisacek, F., 2019, In : Journal of Proteome Research. 18, 2, p. 664-677 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Glycomics
Glycosylation
Bioinformatics
Genomics
Computational Biology

Influence of surface chemistry on the formation of a protein corona on nanodiamonds

Garcia-Bennett, A. E., Everest-Dass, A., Moroni, I., Rastogi, I. D., Parker, L. M., Packer, N. H. & Brown, L. J., 7 Jun 2019, In : Journal of Materials Chemistry B. 7, 21, p. 3383-3389 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Nanodiamonds
Surface chemistry
Proteins
Surface charge
Diamond

Post-column make-up flow (PCMF) enhances the performance of capillary-flow PGC-LC-MS/MS-based glycomics

Hinneburg, H., Chatterjee, S., Schirmeister, F., Nguyen-Khuong, T., Packer, N. H., Rapp, E. & Thaysen-Andersen, M., 2 Apr 2019, In : Analytical Chemistry. 91, 7, p. 4559-4567 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Capillary flow
Polysaccharides
2-Propanol
Organic solvents
Glycoproteins

Translating N-Glycan analytical applications into clinical strategies for ovarian cancer

Briggs, M. T., Condina, M. R., Klingler-Hoffmann, M., Arentz, G., Everest-Dass, A. V., Kaur, G., Oehler, M. K., Packer, N. H. & Hoffmann, P., May 2019, In : Proteomics - Clinical Applications. 13, 3, 15 p., 1800099.

Research output: Contribution to journalArticleResearchpeer-review

Glycosylation
Ovarian Neoplasms
Polysaccharides
Tissue
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry