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Personal profile

Research interests

We now know that sugars attached to proteins and lipids on every cell (glycans) are intricately involved in bacterial and viral infection, the immune responses (both innate and acquired), all cancers, lung disease, brain function, fertilisation, cardiovascular disease and a multitude of other cellular mechanisms in human and all other species. My objective is to increase the scientific research activity in this field so that beneficial improvements to our biological understanding, and ultimately treatment, of health and disease can be achieved. To implement my objective, I have spent the last almost 30 years or so (with some time out to rear three children) applying my knowledge and leadership skills to achieve this implementation.

Biography

Prof Nicki Packer has had an extensive and varied career in biochemical research in both Chemistry and Biological Sciences. She was part of the team that established the Australian Proteome Analysis Facility (APAF) and co-founded Proteome Systems Limited, an Australian biotechnology company in which her group developed a platform of glycoanalytical technology and informatics tools. She is now Professor of Glycoproteomics, Director of the MQ Biomolecular Discovery & Design Research Centre and Consultant to APAF at Macquarie University, Sydney, Australia. She has gained international and national profile by linking glycomics with the proteomics and bioinformatics approaches to biological functional research. Her research interests are now in the structure, function, informatics and application of glycans and their conjugates as molecular markers, particularly in their role in cancer, therapeutics and microbial infection. Nicki has published extensively on glycomics research and works closely with industry.

Education/Academic qualification

Biochemistry, PhD, University of Sydney

1 Jan 197331 Dec 1977

External positions

Principal Research Leader, Institute for Glycomics

1 Jan 201731 Dec 2021

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Projects

Research Outputs

Changes in dietary fiber intake in mice reveal associations between colonic mucin O-glycosylation and specific gut bacteria

Gamage, H. K. A. H., Chong, R. W. W., Bucio-Noble, D., Kautto, L., Hardikar, A. A., Ball, M. S., Molloy, M. P., Packer, N. H. & Paulsen, I. T., 29 Sep 2020, In : Gut Microbes. 12, 1, p. 1-15 15 p., e1802209.

Research output: Contribution to journalArticle

Open Access
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  • 4 Citations (Scopus)

    GlyGen: computational and informatics resources for glycoscience

    York, W. S., Mazumder, R., Ranzinger, R., Edwards, N., Kahsay, R., Aoki-Kinoshita, K. F., Campbell, M. P., Cummings, R. D., Feizi, T., Martin, M., Natale, D. A., Packer, N. H., Woods, R. J., Agarwal, G., Arpinar, S., Bhat, S., Blake, J., Castro, L. J. G., Fochtman, B., Gildersleeve, J. & 16 others, Goldman, R., Holmes, X., Jain, V., Kulkarni, S., Mahadik, R., Mehta, A., Mousavi, R., Nakarakommula, S., Navelkar, R., Pattabiraman, N., Pierce, M. J., Ross, K., Vasudev, P., Vora, J., Williamson, T. & Zhang, W., Feb 2020, In : Glycobiology. 30, 2, p. 72-73 2 p.

    Research output: Contribution to journalLetter

    8 Citations (Scopus)

    Interaction between Polysialic Acid and the MARCKS-ED Peptide at the Molecular Level

    Iqbal, S., Walsh, T. R., Rodger, A. & Packer, N. H., 1 Jul 2020, In : ACS Chemical Neuroscience. 11, 13, p. 1944-1954 11 p.

    Research output: Contribution to journalArticle

  • Lipopolysaccharide and morphine-3-glucuronide-induced immune signalling increases the expression of polysialic acid in PC12 Cells

    Iqbal, S., Parker, L. M., Everest Dass, A. V., Moh, E. S. X., Sayyadi, N., Hutchinson, M. R. & Packer, N. H., Feb 2020, In : Molecular Neurobiology. 57, 2, p. 964-975 12 p.

    Research output: Contribution to journalArticle