After completing an Undergraduate Masters in Molecular and Cellular Biology at the University of Bath, England, Nicolle started her career as a transgenic technician at the Francis Crick Institute, London. There, she spent over three years contributing to all aspects of the Genetic Manipulation Service including microinjection, germplasm and embryo cryopreservation and surgical techniques. Her specialism was mouse and human stem cell culture and manipulation. She is currently a member of the International Society for Transgenic Technologies (ISTT). Nicolle joined the Transgenic Animal Unit (within the Dementia Research Unit) at the University of New South Wales in August 2017. She primarily worked in design and execution of strategies for generation of mouse models of disease. In August 2018, she subsequently joined the Genetic Manipulation team as part of the Dementia Research Centre at Macquarie University, to further contribute to technology development in field of transgenics.

Nicolle's area of expertise is in Genetic Manipulation, and seeks to contribute to development within the field:

• Utilisation of current manipulation techniques in a wider breadth of animal models.
• Refinement of current techniques to allow streamlining of workflows and higher efficiency.
• Creation of novel gene modification techniques to project the field forwards.