Nitin Chitranshi

Dr

  • 239 Citations
  • 10 h-Index
20062019
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Personal profile

Biography

Dr Nitin Chitranshi has bachelor and master's degree in Pharmaceutical Sciences. He obtained his doctoral degree in Clinical Medicine and has more than 8 years of teaching and research experience. Dr Chitranshi has also been the research intern at Swiss Institute of Bioinformatics, University of Geneva, Switzerland. He has more than 20 publications and presented in >30 national and international conferences. Dr Chitranshi was a visiting Scientist at Cambridge University, University of Miami and University de Murcia. Currently, his lab efforts are directed in the following key areas: 

  • Neuroserpin-Plasmin interaction in the retina
  • Neurotrophin factor (BDNF, NT3/4/5) signalling in the retina.
  • Viral vector gene delivery and gene manipulation in Rat models and GMO mice.
  • Study signalling proteins affecting retinal cell survival in pathological conditions (Glaucoma, Alzheimer's, and Hypertension).
  • Structural and functional changes in retina involving pERG, pSTR and OCT in rodent’s model.
  • Neuroprotective molecules studies in RGCs damage.
  • High IOP rodent models to study molecular effects on the retina.
  • Membrane protein biology with emphasis on post-translational modifications of the caveolar proteins in glaucoma.
  • Rodents model of optic neuritis with optic nerve micro-injection.
  • Electrode implantation for VEPs recoding in rodents
  • Immunocytochemistry, Immunoblotting, cell culture and handling GMO's.

 

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  • 23 Similar Profiles
Glaucoma Medicine & Life Sciences
Retina Medicine & Life Sciences
Retinoid X Receptors Medicine & Life Sciences
Neurodegenerative Diseases Medicine & Life Sciences
Brain-Derived Neurotrophic Factor Medicine & Life Sciences
trkB Receptor Medicine & Life Sciences
Amyloid Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences

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Research Outputs 2006 2019

  • 239 Citations
  • 10 h-Index
  • 23 Article
  • 5 Meeting abstract
  • 3 Review article
  • 1 Short survey
Open Access
File
Vertebrate Photoreceptor Cells
Oxidative Phosphorylation
Amyloid
Photoreceptor Cells
Alzheimer Disease

Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease

You, Y., Joseph, C., Wang, C., Gupta, V., Liu, S., Yiannikas, C., Chua, B., Chitranshi, N., Shen, T., Dheer, Y., Invernizzi, A., Borotkanics, R., Barnett, M., Graham, S. L. & Klistorner, A., 1 Feb 2019, In : Brain; a journal of neurology. 142, 2, p. 426-442 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Demyelinating Diseases
Neurodegenerative Diseases
Radiation
Myelin Sheath
Neuroglia

Differing structural and functional patterns of optic nerve damage in multiple sclerosis and neuromyelitis optica spectrum disorder

Shen, T., You, Y., Arunachalam, S., Fontes, A., Liu, S., Gupta, V., Parratt, J., Wang, C., Barnett, M., Barton, J., Chitranshi, N., Zhu, L., Fraser, C. L., Graham, S. L., Klistorner, A. & Yiannikas, C., Mar 2019, In : Ophthalmology. 126, 3, p. 445-453 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Neuromyelitis Optica
Optic Nerve
Multiple Sclerosis
Visual Evoked Potentials
Ganglia

Loss of Shp2 rescues BDNF/TrkB signaling and contributes to improved retinal ganglion cell neuroprotection

Chitranshi, N., Dheer, Y., Mirzaei, M., Wu, Y., Salekdeh, G. H., Abbasi, M., Gupta, V., Vander Wall, R., You, Y., Graham, S. L. & Gupta, V., 6 Feb 2019, In : Molecular Therapy. 27, 2, p. 424-441 18 p.

Research output: Contribution to journalArticleResearchpeer-review

trkB Receptor
Retinal Ganglion Cells
Glaucoma
Endoplasmic Reticulum Stress
Apoptosis
Retinoid X Receptors
Molecular Dynamics Simulation
Transcription Factors
Pharmacology
Ligands