• 308 Citations
  • 10 h-Index
20062020

Research output per year

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Personal profile

Biography

Dr Nitin Chitranshi has bachelor and master's degree in Pharmaceutical Sciences. He obtained his doctoral degree in Clinical Medicine and has more than 8 years of teaching and research experience. Dr Chitranshi has also been the research intern at Swiss Institute of Bioinformatics, University of Geneva, Switzerland. He has more than 20 publications and presented in >30 national and international conferences. Dr Chitranshi was a visiting Scientist at Cambridge University, University of Miami and University de Murcia. Currently, his lab efforts are directed in the following key areas: 

  • Neuroserpin-Plasmin interaction in the retina
  • Neurotrophin factor (BDNF, NT3/4/5) signalling in the retina.
  • Viral vector gene delivery and gene manipulation in Rat models and GMO mice.
  • Study signalling proteins affecting retinal cell survival in pathological conditions (Glaucoma, Alzheimer's, and Hypertension).
  • Structural and functional changes in retina involving pERG, pSTR and OCT in rodent’s model.
  • Neuroprotective molecules studies in RGCs damage.
  • High IOP rodent models to study molecular effects on the retina.
  • Membrane protein biology with emphasis on post-translational modifications of the caveolar proteins in glaucoma.
  • Rodents model of optic neuritis with optic nerve micro-injection.
  • Electrode implantation for VEPs recoding in rodents
  • Immunocytochemistry, Immunoblotting, cell culture and handling GMO's.

 

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Projects

Research Outputs

  • 308 Citations
  • 10 h-Index
  • 24 Article
  • 5 Meeting abstract
  • 3 Review article
  • 1 Short survey

Caveolin-1 ablation imparts partial protection against inner retinal injury in experimental glaucoma and reduces apoptotic activation

Abbasi, M., Gupta, V. K., Chitranshi, N., Gupta, V. B., Mirzaei, M., Dheer, Y., Garthwaite, L., Zaw, T., Parton, R. G., You, Y. & Graham, S. L., 23 Jun 2020, In : Molecular Neurobiology. 57, p. 3759-3784 26 p.

Research output: Contribution to journalArticle

  • Open Access
    File
  • 3 Citations (Scopus)
    13 Downloads (Pure)

    Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease

    You, Y., Joseph, C., Wang, C., Gupta, V., Liu, S., Yiannikas, C., Chua, B., Chitranshi, N., Shen, T., Dheer, Y., Invernizzi, A., Borotkanics, R., Barnett, M., Graham, S. L. & Klistorner, A., 1 Feb 2019, In : Brain. 142, 2, p. 426-442 17 p.

    Research output: Contribution to journalArticle

  • 18 Citations (Scopus)

    Differing structural and functional patterns of optic nerve damage in multiple sclerosis and neuromyelitis optica spectrum disorder

    Shen, T., You, Y., Arunachalam, S., Fontes, A., Liu, S., Gupta, V., Parratt, J., Wang, C., Barnett, M., Barton, J., Chitranshi, N., Zhu, L., Fraser, C. L., Graham, S. L., Klistorner, A. & Yiannikas, C., Mar 2019, In : Ophthalmology. 126, 3, p. 445-453 9 p.

    Research output: Contribution to journalArticle

  • 19 Citations (Scopus)

    Loss of Shp2 rescues BDNF/TrkB signaling and contributes to improved retinal ganglion cell neuroprotection

    Chitranshi, N., Dheer, Y., Mirzaei, M., Wu, Y., Salekdeh, G. H., Abbasi, M., Gupta, V., Vander Wall, R., You, Y., Graham, S. L. & Gupta, V., 6 Feb 2019, In : Molecular Therapy. 27, 2, p. 424-441 18 p.

    Research output: Contribution to journalArticle

  • 6 Citations (Scopus)