Projects per year
Personal profile
Biography
Dr. Nitin Chitranshi holds both a bachelor's and master's degree in Pharmaceutical Sciences. He earned his Doctoral degree in Clinical Medicine and possesses over 14 years of valuable teaching and research expertience. Dr. Chitranshi served as a research intern at the Swiss Institute of Bioinformatics, University of Geneva, Switzerland, and has an extensive publication record with more than 60 articles. Additionally, he has made presentations at over 30 national and international conferences.
During his career, Dr. Chitranshi has served as a visiting Scientist at renowned institutions such as Cambridge University, the University of Miami, and the University de Murcia. His proficiency extends to various areas, including computer-aided drug design, 3D pharmacophore, virtual screening, 3D-QSAR, fingerprinting, and Molecular Dynamics. Furthermore, he has contributed to formulation design and the development of new drug delivery systems, particularly focusing on lipid-based nanoparticles.
Currently, Dr. Chitranshi's laboratory is dedicated to advancing research in key areas such as:
- Neuroserpin-Plasmin interaction in the retina
- Neurotrophin factor (BDNF, NT3/4/5) signalling in the retina.
- Viral vector gene delivery and gene manipulation in Rat models and GMO mice.
- Study signalling proteins affecting retinal cell survival in pathological conditions (Glaucoma, Alzheimer's, and Hypertension).
- Structural and functional changes in retina involving pERG, pSTR and OCT in rodent’s model.
- Neuroprotective molecules studies in RGCs damage.
- High IOP rodent models to study molecular effects on the retina.
- Membrane protein biology with emphasis on post-translational modifications of the caveolar proteins in glaucoma.
- Rodents model of optic neuritis with optic nerve micro-injection.
- Electrode implantation for VEPs recoding in rodents
- Immunocytochemistry, Immunoblotting, cell culture and handling GMO's.
- NDDS- nanoparticles, lipid nanocarriers, dendrimer, micelles
- CADD, docking, MD simulation, 2D-3D fingerprinting
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Retinoid-X-receptor Agonists as Novel Neuroprotectants in Glaucoma
Graham, S. L., Gupta, V. & Chitranshi, N.
1/07/23 → 30/06/26
Project: Research
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Let there be light- Modified Serpin as a Dual Function Therapeutic Agent in Glaucoma
Gupta, V., Graham, S. L., Rajala, R. V. S., Gupta, V. B., Komaromy, A., Mirzaei, M. & Chitranshi, N.
1/05/23 → 30/04/27
Project: Research
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MNDRA Innovator: Nucleoredoxin (NRX), a novel gene therapy target against TDP43 multifaceted pathogenic mechanisms.
Parakh, S., Gupta, V., Chitranshi, N., McCann, E. & Atkin, J.
30/06/23 → 29/06/24
Project: Research
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IP Dev Fund : Developing Neuroserpin molecule for neuroprotective translational applications
Gupta, V., Graham, S. L. & Chitranshi, N.
1/01/22 → 31/12/22
Project: Research
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The next generation of medicine-Gene therapy for glaucoma
Basavarajappa, D., Chitranshi, N. & Vishwanath, D.
1/01/22 → 31/12/22
Project: Research
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Brain-derived neurotrophic factor Val66Met is associated with variation in cortical structure in healthy aging subjects
Shen, T., Sheriff, S., You, Y., Jiang, J., Schulz, A., Francis, H., Mirzaei, M., Saks, D., Palanivel, V., Basavarajappa, D., Chitranshi, N., Gupta, V., Wen, W., Sachdev, P. S., Jia, H., Sun, X., Graham, S. L. & Gupta, V. K., 1 Oct 2024, In: Aging and Disease. 15, 5, p. 2315-2327 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Downloads (Pure) -
Elevated CD11b-positive microglia and CD3-positive cells in glaucoma: insights from post-mortem retinal analysis
Salkar, A. A., Vander Wall, R., Basavarajappa, D., Chitranshi, N., Gupta, V., You, Y. & Graham, S. L., 17 Jun 2024, In: Investigative Ophthalmology and Visual Science. 65, 7, p. 6768 1 p.Research output: Contribution to journal › Meeting abstract
File12 Downloads (Pure) -
Genetic risk, inflammation, and therapeutics: an editorial overview of recent advances in aging brains and neurodegeneration
Gupta, V., Chitranshi, N. & Gupta, V. B., 26 Aug 2024, In: Aging and Disease. 15, 5, p. 1989-1993 5 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile13 Downloads (Pure) -
Glial cell activation and immune responses in glaucoma: a systematic review of human postmortem studies of the retina and optic nerve
Salkar, A., Vander Wall, R., Basavarajappa, D., Chitranshi, N., Parilla, G. E., Mirzaei, M., Yan, P., Graham, S. & You, Y., 1 Oct 2024, In: Aging and Disease. 15, 5, p. 2069-2083 15 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile16 Downloads (Pure) -
Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches
Welsh, J. A., Goberdhan, D. C. I., O’Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., Falcon-Perez, J. M., Fu, Q. L., Hill, A. F., Lenassi, M., Lim, S. K., Mahoney, M. G., Mohanty, S., Möller, A., Nieuwland, R., Ochiya, T., & 54 others , Feb 2024, In: Journal of Extracellular Vesicles. 13, 2, p. 1-84 84 p., e12404.Research output: Contribution to journal › Article › peer-review
Open AccessFile521 Citations (Scopus)31 Downloads (Pure)
Prizes
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Dean’s Award for Excellence in Higher Degree Research
Chitranshi, Nitin (Recipient), 2018
Prize: Honorary award
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Activities
- 1 Membership of committee
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Faculty of Medicine, Health and Human Sciences (Organisational unit)
Mitchell Sarkies (Member), Fiona Bright (Member), Katie De Luca (Member), Emre Ilhan (Member), Amy Nguyen (Member), Elizabeth Austin (Member), Ann Carrigan (Member), Karla Seaman (Member), Chris Bladen (Member), Annika van Hummel (Member), Jannah Baker (Member), Robert Ross (Member), Sian Genoud (Member), Emily Don (Chair), Nitin Chitranshi (Member), Rae-Anne Hardie (Chair), Rimante Ronto (Member), Gemma Sicouri (Member), Kelly Williams (Member), Syeda Somyyah Owais (Member), Anna Guller (Member), Robert Newport (Member), Marina Junqueira Santiago (Member), Philippe Gilchrist (Member), Jessamine Chen (Member), Ella Oar (Member), Alison Hogan (Member), Jodie Wills (Member), Kathleen Yin (Member), Gillian Hulst (Member), Benjamin Brown (Member), Loes Koring (Member), Stephney Whillier (Member), Milena Gandy (Member), Carly Johnco (Member), Lauren McLellan (Member) & Michael Swain (Member)
2020 → …Activity: Membership › Membership of committee