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20062023

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Personal profile

Biography

Dr. Nitin Chitranshi holds both a bachelor's and master's degree in Pharmaceutical Sciences. He earned his Doctoral degree in Clinical Medicine and possesses over 14 years of valuable teaching and research expertience. Dr. Chitranshi served as a research intern at the Swiss Institute of Bioinformatics, University of Geneva, Switzerland, and has an extensive publication record with more than 60 articles. Additionally, he has made presentations at over 30 national and international conferences.

During his career, Dr. Chitranshi has served as a visiting Scientist at renowned institutions such as Cambridge University, the University of Miami, and the University de Murcia. His proficiency extends to various areas, including computer-aided drug design, 3D pharmacophore, virtual screening, 3D-QSAR, fingerprinting, and Molecular Dynamics. Furthermore, he has contributed to formulation design and the development of new drug delivery systems, particularly focusing on lipid-based nanoparticles.

Currently, Dr. Chitranshi's laboratory is dedicated to advancing research in key areas such as:

  • Neuroserpin-Plasmin interaction in the retina
  • Neurotrophin factor (BDNF, NT3/4/5) signalling in the retina.
  • Viral vector gene delivery and gene manipulation in Rat models and GMO mice.
  • Study signalling proteins affecting retinal cell survival in pathological conditions (Glaucoma, Alzheimer's, and Hypertension).
  • Structural and functional changes in retina involving pERG, pSTR and OCT in rodent’s model.
  • Neuroprotective molecules studies in RGCs damage.
  • High IOP rodent models to study molecular effects on the retina.
  • Membrane protein biology with emphasis on post-translational modifications of the caveolar proteins in glaucoma.
  • Rodents model of optic neuritis with optic nerve micro-injection.
  • Electrode implantation for VEPs recoding in rodents
  • Immunocytochemistry, Immunoblotting, cell culture and handling GMO's.
  • NDDS- nanoparticles, lipid nanocarriers, dendrimer, micelles
  • CADD, docking, MD simulation, 2D-3D fingerprinting 

 

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