Nitin Chitranshi

Dr

  • 251 Citations
  • 10 h-Index
20062023
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Research Outputs 2006 2019

  • 251 Citations
  • 10 h-Index
  • 23 Article
  • 5 Meeting abstract
  • 3 Review article
  • 1 Short survey
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Article
2019
Open Access
File
Vertebrate Photoreceptor Cells
Oxidative Phosphorylation
Amyloid
Photoreceptor Cells
Alzheimer Disease

Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease

You, Y., Joseph, C., Wang, C., Gupta, V., Liu, S., Yiannikas, C., Chua, B., Chitranshi, N., Shen, T., Dheer, Y., Invernizzi, A., Borotkanics, R., Barnett, M., Graham, S. L. & Klistorner, A., 1 Feb 2019, In : Brain; a journal of neurology. 142, 2, p. 426-442 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Demyelinating Diseases
Neurodegenerative Diseases
Radiation
Myelin Sheath
Neuroglia

Differing structural and functional patterns of optic nerve damage in multiple sclerosis and neuromyelitis optica spectrum disorder

Shen, T., You, Y., Arunachalam, S., Fontes, A., Liu, S., Gupta, V., Parratt, J., Wang, C., Barnett, M., Barton, J., Chitranshi, N., Zhu, L., Fraser, C. L., Graham, S. L., Klistorner, A. & Yiannikas, C., Mar 2019, In : Ophthalmology. 126, 3, p. 445-453 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Neuromyelitis Optica
Optic Nerve
Multiple Sclerosis
Visual Evoked Potentials
Ganglia

Loss of Shp2 rescues BDNF/TrkB signaling and contributes to improved retinal ganglion cell neuroprotection

Chitranshi, N., Dheer, Y., Mirzaei, M., Wu, Y., Salekdeh, G. H., Abbasi, M., Gupta, V., Vander Wall, R., You, Y., Graham, S. L. & Gupta, V., 6 Feb 2019, In : Molecular Therapy. 27, 2, p. 424-441 18 p.

Research output: Contribution to journalArticleResearchpeer-review

trkB Receptor
Retinal Ganglion Cells
Glaucoma
Endoplasmic Reticulum Stress
Apoptosis

Molecular docking, dynamics, and pharmacology studies on bexarotene as an agonist of ligand-activated transcription factors, retinoid X receptors

Chitranshi, N., Dheer, Y., Kumar, S., Graham, S. L. & Gupta, V., 1 Jul 2019, In : Journal of Cellular Biochemistry. 120, 7, p. 11745-11760 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinoid X Receptors
Molecular Dynamics Simulation
Transcription Factors
Pharmacology
Ligands

Retinoid x receptor modulation protects against ER stress response and rescues glaucoma phenotypes in adult mice

Dheer, Y., Chitranshi, N., Gupta, V., Sharma, S., Pushpitha, K., Abbasi, M., Mirzaei, M., You, Y., Graham, S. L. & Gupta, V., 1 Apr 2019, In : Experimental Neurology. 314, p. 111-125 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinoid X Receptors
Retinoids
Glaucoma
Phenotype
Retina

Sex-specific effect of BDNF Val66Met genotypes on the progression of open-angle glaucoma

Shen, T., Gupta, V. K., Klistorner, A., Chitranshi, N., Graham, S. L. & You, Y., 1 Mar 2019, In : Investigative ophthalmology & visual science. 60, 4, p. 1069-1075 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Open Angle Glaucoma
Brain-Derived Neurotrophic Factor
Genotype
Nerve Fibers
Homozygote
Protein Biosynthesis
Amyloid beta-Protein Precursor
Retina
Alzheimer Disease
Up-Regulation
2018

Bexarotene modulates Retinoid-X-receptor expression and is protective against neurotoxic endoplasmic reticulum stress response and apoptotic pathway activation

Dheer, Y., Chitranshi, N., Gupta, V., Abbasi, M., Mirzaei, M., You, Y., Chung, R., Graham, S. L. & Gupta, V., Dec 2018, In : Molecular Neurobiology. 55, 12, p. 9043-9056 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinoid X Receptors
Endoplasmic Reticulum Stress
Retinoid X Receptor gamma
Retinoid X Receptor beta
Brain

Glaucoma pathogenesis and neurotrophins: focus on the molecular and genetic basis for therapeutic prospects

Chitranshi, N., Dheer, Y., Abbasi, M., You, Y., Graham, S. L. & Gupta, V., 2018, In : Current Neuropharmacology. 16, 7, p. 1018 - 1035 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Nerve Growth Factors
Glaucoma
Molecular Biology
Retinal Ganglion Cells
Endoplasmic Reticulum Stress
2017

Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes

Mirzaei, M., Gupta, V. B., Chick, J. M., Greco, T. M., Wu, Y., Chitranshi, N., Wall, R. V., Hone, E., Deng, L., Dheer, Y., Abbasi, M., Rezaeian, M., Braidy, N., You, Y., Salekdeh, G. H., Haynes, P. A., Molloy, M. P., Martins, R., Cristea, I. M., Gygi, S. P. & 2 othersGraham, S. L. & Gupta, V. K., 4 Oct 2017, In : Scientific Reports. 7, 1, p. 1-16 16 p., 12685.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Proteome
Neurodegenerative Diseases
Glaucoma
Proteins
Vitreous Body

Computational analysis unravels novel destructive single nucleotide polymorphisms in the non-synonymous region of human caveolin gene

Chitranshi, N., Dheer, Y., Wall, R. V., Gupta, V., Abbasi, M., Graham, S. L. & Gupta, V., 1 Mar 2017, In : Gene Reports. 6, p. 142-157 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Caveolins
Single Nucleotide Polymorphism
Cell Membrane Structures
Genes
Protein Stability

Glaucoma is associated with plasmin proteolytic activation mediated through oxidative inactivation of neuroserpin

Gupta, V., Mirzaei, M., Gupta, V. B., Chitranshi, N., Dheer, Y., Vander Wall, R., Abbasi, M., You, Y., Chung, R. & Graham, S., 1 Dec 2017, In : Scientific Reports. 7, p. 1-18 18 p., 8412.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Fibrinolysin
Glaucoma
Retina
Methionine
Serpins

PTPN11 induces endoplasmic stress and apoptosis in SH-SY5Y cells

Chitranshi, N., Dheer, Y., Gupta, V., Abbasi, M., Mirzaei, M., You, Y., Chung, R., Graham, S. L. & Gupta, V., 19 Nov 2017, In : Neuroscience. 364, p. 175-189 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Endoplasmic Reticulum Stress
Apoptosis
trkB Receptor
Up-Regulation
Dependovirus
2016

Amyloid β accumulation and inner retinal degenerative changes in Alzheimer's disease transgenic mouse

Gupta, V. K., Chitranshi, N., Gupta, V. B., Golzan, M., Dheer, Y., Wall, R. V., Georgevsky, D., King, A. E., Vickers, J. C., Chung, R. & Graham, S., 3 Jun 2016, In : Neuroscience Letters. 623, p. 52-56 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyloid
Transgenic Mice
Retina
Alzheimer Disease
Intraocular Pressure

Molecular determinants and interaction data of cyclic peptide inhibitor with the extracellular domain of TrkB receptor

Chitranshi, N., Gupta, V., Dheer, Y., Gupta, V., Vander Wall, R. & Graham, S., 1 Mar 2016, In : Data in Brief. 6, p. 776-782 7 p.

Research output: Contribution to journalArticleResearchpeer-review

brain
determinants
interaction
activation
regulation
2015

Exploring the molecular interactions of 7,8-dihydroxyflavone and its derivatives with TrkB and VEGFR2 proteins

Chitranshi, N., Gupta, V., Kumar, S. & Graham, S. L., 3 Sep 2015, In : International Journal of Molecular Sciences. 16, 9, p. 21087-21108 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Flavonoids
Phosphorylation
Molecular interactions
molecular interactions
trkB Receptor

Visual evoked potential recording in a rat model of experimental optic nerve demyelination

You, Y., Gupta, V. K., Chitranshi, N., Reedman, B., Klistorner, A. & Graham, S. L., 29 Jul 2015, In : Journal of Visualized Experiments. 101, p. 1-5 5 p., e52934.

Research output: Contribution to journalArticleResearchpeer-review

Visual Evoked Potentials
Bioelectric potentials
Demyelinating Diseases
Optic Nerve
Rats
2014

Brain derived neurotrophic factor is involved in the regulation of glycogen synthase kinase 3β (GSK3β) signalling

Gupta, V., Chitranshi, N., You, Y., Gupta, V., Klistorner, A. & Graham, S., 24 Oct 2014, In : Biochemical and Biophysical Research Communications. 454, 3, p. 381-386 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Glycogen Synthase Kinases
Brain-Derived Neurotrophic Factor
Phosphorylation
trkB Receptor
Biochemical Phenomena
2013

New molecular scaffolds for the design of Alzheimer's acetylcholinesterase inhibitors identified using ligand- and receptor-based virtual screening

Chitranshi, N., Gupta, S., Tripathi, P. K. & Seth, P. K., May 2013, In : Medicinal Chemistry Research. 22, 5, p. 2328-2345 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Cholinesterase Inhibitors
Acetylcholinesterase
Scaffolds
Screening
Ligands
2011

Antiaggressive activity of Nyctanthes arbor-tristis leaves in rodents

Tripathi, S., Tripathi, P. K., Chitranshi, N. & Singh, P. N., 2011, In : Pharmacologyonline. 1, p. 1290-1300 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Aggression
Rodentia
Diazepam
Running
Foot
2006

Pharmacognostic evaluation of Curcuma aeurigenosa Roxb

Srivastava, S., Chitranshi, N., Srivastava, S., Dan, M., Rawat, A. K. S. & Pushpangadan, P., Sep 2006, In : Natural Product Sciences. 12, 3, p. 162-165 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Ashes
Curcuma
Rhizome
Astringents
Tannins

Pharmacognostic evaluation of Curcuma haritha Linn

Srivastava, S., Srivastava, S., Chitranshi, N., Dan, M., Rawat, A. K. S. & Pushpangadan, P., Nov 2006, In : Journal of Scientific and Industrial Research. 65, 11, p. 916-920 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Ashes
Tannins
Starch
Sugars
Distillation