Projects per year
Personal profile
Biography
Dr Ole Tietz is a Senior Research Fellow and Group Leader at the Dementia Research Centre, Macquarie Medical School. Ole studied Chemistry at Imperial College London, UK, and completed his PhD in Oncology at the University of Alberta, Canada. He held research fellowships at the University of Cambridge, where he developed imaging agents for early markers of neurodegeneration, and the University of Oxford, where he developed new therapeutics to treat cancer. Ole leads the Chemistry Group at the Dementia Research Centre and seeks to develop effective agents to diagnose and treat neurodegenerative diseases.
Research interests
Ole is interested in developing novel drugs for the effective diagnosis and treatment of neurodegenerative diseases, including Dementia, Alzheimer's Disease, Motor Neuron Disease, Parkinsons Disease, and Chronic traumatic encephalopathy. This includes the rational design of small molecules against protein-protein interfaces, and the development of biologics, including peptides and antibodies, to target important biomolecular pathways that drive disease progression in neurodegenerative disease. Ole's research is building therapeutics for a world without dementia.
Education/Academic qualification
Oncology, PhD, Novel radiotracers for the molecular imaging of cyclooxygenase-2 using positron emission tomography, University of Alberta
6 Jan 2011 → 18 Nov 2015
Award Date: 18 Nov 2015
Biomedical Physical Chemistry, MRes, Imaging CXCR4 using fluorescence and MRI, Imperial College London
5 Oct 2008 → 15 Dec 2009
Award Date: 12 Oct 2010
Chemistry, BSc
3 Oct 2005 → 25 Jun 2008
Award Date: 14 Oct 2008
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Collaborations and top research areas from the last five years
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IDEAS 23: New biological drugs to treat Alzheimer's disease
Ittner, L., Ariawan, D., Llorente, B. & Tietz, O.
1/01/24 → 31/12/27
Project: Research
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LE23 - USYD Led: Radiochemistry Facility for Biomolecule Characterisation in Living Systems
Kassiou, M., Stenzel, M., New, E. J., Goldys, E., Pascali, G., Codd, R., Ittner, L., Tietz, O., Meikle, S., Calamante, F. & Vittorio, O.
2/06/23 → 1/06/24
Project: Research
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A fluorescent molecular imaging probe with selectivity for soluble tau aggregated protein
Zhao, Y., Tietz, O., Kuan, W. L., Haji-Dheere, A. K., Thompson, S., Vallin, B., Ronchi, E., Tóth, G., Klenerman, D. & Aigbirhio, F. I., 14 May 2020, In: Chemical Science. 11, 18, p. 4773-4778 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)46 Downloads (Pure) -
Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson’s disease
Kuan, W-L., Stott, K., He, X., Wood, T. C., Yang, S., Kwok, J. C. F., Hall, K., Zhao, Y., Tietz, O., Aigbirhio, F. I., Vernon, A. C. & Barker, R. A., 1 Feb 2021, In: Molecular Psychiatry. 26, 2, p. 556-567 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)91 Downloads (Pure) -
PET imaging of cyclooxygenase-2 (COX-2) in a pre-clinical colorectal cancer model
Tietz, O., Wuest, M., Marshall, A., Glubrecht, D., Hamann, I., Wang, M., Bergman, C., Way, J. D. & Wuest, F., 26 Apr 2016, In: EJNMMI Research. 6, 1, p. 1-11 11 p., 37.Research output: Contribution to journal › Article › peer-review
Open AccessFile34 Citations (Scopus)62 Downloads (Pure) -
Impact of structural alterations on the radiopharmacological profile of 18F-labeled pyrimidines as cyclooxygenase-2 (COX-2) imaging agents
Tietz, O., Marshall, A., Bergman, C., Wuest, M. & Wuest, F., 1 Jul 2018, In: Nuclear Medicine and Biology. 62-63, p. 9-17 9 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
VCAM-1 targeted alpha-particle therapy for early brain metastases
Corroyer-Dulmont, A., Valable, S., Falzone, N., Frelin-Labalme, A. M., Tietz, O., Toutain, J., Soto, M. S., Divoux, D., Chazalviel, L., Pérès, E. A., Sibson, N. R., Vallis, K. A. & Bernaudin, M., 5 Mar 2020, In: Neuro-Oncology. 22, 3, p. 357-368 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile32 Citations (Scopus)71 Downloads (Pure)