Personal profile
Biography
Dr Ole Tietz is a Senior Research Fellow and Group Leader at the Dementia Research Centre, Macquarie Medical School. Ole studied Chemistry at Imperial College London, UK, and completed his PhD in Oncology at the University of Alberta, Canada. He held prestigious research fellowships at the University of Cambridge and the University of Oxford. Ole is co-founder and CSO of Synaptra BIO, a Macquarie University spin-out company seeking to develop new therapeutics to treat Demenita. Ole leads the Chemistry Group at the Dementia Research Centre and works on the development of new therapeutics and diagnostics to effectively treat neurodegenerative diseases.
Research interests
Ole is interested in developing novel drugs for the effective diagnosis and treatment of neurodegenerative diseases, including Dementia, Alzheimer's Disease, and Motor Neuron Disease. This includes the rational design of small molecules against protein-protein interfaces, and the development of biologics, including peptides and antibodies, to target important biomolecular pathways that drive disease progression in neurodegenerative disease. Ole aims to bring new drugs into clinical use that will help build a world without dementia.
Education/Academic qualification
Oncology, PhD, Novel radiotracers for the molecular imaging of cyclooxygenase-2 using positron emission tomography, University of Alberta
6 Jan 2011 → 18 Nov 2015
Award Date: 18 Nov 2015
Biomedical Physical Chemistry, MRes, Imaging CXCR4 using fluorescence and MRI, Imperial College London
5 Oct 2008 → 15 Dec 2009
Award Date: 12 Oct 2010
Chemistry, BSc
3 Oct 2005 → 25 Jun 2008
Award Date: 14 Oct 2008
External positions
Chief Scientific Officer, Synaptra BIO Pty Ltd
1 Dec 2025 → …
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Collaborations and top research areas from the last five years
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ID24 (UTS led): Bioengineering Protein Nanocages for Preventive Vaccination Against Alzheimer’s Disease
Care, A. (Chief Investigator), Collins-Praino, L. (Chief Investigator), Saunders, B. M. (Chief Investigator), van der Hoven, J. (Primary Chief Investigator), Rennie, C. (Chief Investigator), Ittner, L. (Associate Investigator) & Tietz, O. (Associate Investigator)
6/06/25 → 5/06/29
Project: Research
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FightMND 24: Pathway to Precision: Developing Specific TDP-43 Degraders for MND
Ke, Y. (Primary Chief Investigator), Ittner, L. (Chief Investigator), Tietz, O. (Chief Investigator) & Rowe, D. (Partner Investigator)
1/02/25 → 31/01/28
Project: Research
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DEV 24: A novel protein-protein interaction inhibitor to treat Alzheimer’s disease
Ittner, L. (Primary Chief Investigator), Meier, R. (Chief Investigator), Van Eersel, J. (Chief Investigator), Tietz, O. (Chief Investigator), Ariawan, D. (Chief Investigator), Bi, M. (Chief Investigator) & Goozee, K. (Associate Investigator)
1/01/25 → 31/12/27
Project: Research
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FightMND Impact24: Neuroimaging of TDP-43
Tietz, O. (Primary Chief Investigator), Ittner, L. (Co-Investigator) & Meikle, S. (Co-Investigator)
1/10/24 → 30/09/26
Project: Research
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IDEAS 23: New biological drugs to treat Alzheimer's disease
Ittner, L. (Primary Chief Investigator), Ariawan, D. (Chief Investigator), Llorente, B. (Chief Investigator) & Tietz, O. (Associate Investigator)
1/01/24 → 31/12/27
Project: Research
Research Outputs
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A fluorescent molecular imaging probe with selectivity for soluble tau aggregated protein
Zhao, Y., Tietz, O., Kuan, W. L., Haji-Dheere, A. K., Thompson, S., Vallin, B., Ronchi, E., Tóth, G., Klenerman, D. & Aigbirhio, F. I., 14 May 2020, In: Chemical Science. 11, 18, p. 4773-4778 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Link opens in a new tab Citations (Scopus)53 Downloads (Pure) -
Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson’s disease
Kuan, W.-L., Stott, K., He, X., Wood, T. C., Yang, S., Kwok, J. C. F., Hall, K., Zhao, Y., Tietz, O., Aigbirhio, F. I., Vernon, A. C. & Barker, R. A., 1 Feb 2021, In: Molecular Psychiatry. 26, 2, p. 556-567 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Link opens in a new tab Citations (Scopus)125 Downloads (Pure) -
PET imaging of cyclooxygenase-2 (COX-2) in a pre-clinical colorectal cancer model
Tietz, O., Wuest, M., Marshall, A., Glubrecht, D., Hamann, I., Wang, M., Bergman, C., Way, J. D. & Wuest, F., 26 Apr 2016, In: EJNMMI Research. 6, 1, p. 1-11 11 p., 37.Research output: Contribution to journal › Article › peer-review
Open AccessFile38 Link opens in a new tab Citations (Scopus)49 Downloads (Pure) -
Impact of structural alterations on the radiopharmacological profile of 18F-labeled pyrimidines as cyclooxygenase-2 (COX-2) imaging agents
Tietz, O., Marshall, A., Bergman, C., Wuest, M. & Wuest, F., 1 Jul 2018, In: Nuclear Medicine and Biology. 62-63, p. 9-17 9 p.Research output: Contribution to journal › Article › peer-review
8 Link opens in a new tab Citations (Scopus) -
VCAM-1 targeted alpha-particle therapy for early brain metastases
Corroyer-Dulmont, A., Valable, S., Falzone, N., Frelin-Labalme, A. M., Tietz, O., Toutain, J., Soto, M. S., Divoux, D., Chazalviel, L., Pérès, E. A., Sibson, N. R., Vallis, K. A. & Bernaudin, M., 5 Mar 2020, In: Neuro-Oncology. 22, 3, p. 357-368 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile35 Link opens in a new tab Citations (Scopus)77 Downloads (Pure)