• 162 Citations
  • 9 h-Index
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Personal profile


Biological engineer with diverse research experience ranging from chlorophyll biosynthesis to designing and building synthetic virus genomes. Proven track record in scientific publications, mentoring and leadership.

Research interests

The Jaschke Lab bridges the fields of Synthetic Biology, Microbiology, Virology, and Systems Biology to answer fundamental questions of:

(1) how to discover all the components necessary to make a functional genome? 

(2) how to reconfigure these components to make engineered genomes more reliable and predictable?

(3) how to engineer biology to benefit human health and reduce impacts on our environment?


We aim to answer important questions by pioneering the science and engineering of synthetic genomes by designing, building, testing, and learning from our designs.

Fingerprint Dive into the research topics where Paul Jaschke is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Rhodobacter sphaeroides Medicine & Life Sciences
Bacteriochlorophylls Medicine & Life Sciences
RNA, Transfer, Met Medicine & Life Sciences
Amber Medicine & Life Sciences
Zinc Medicine & Life Sciences
Genome Medicine & Life Sciences
Synthetic Biology Medicine & Life Sciences
Terminator Codon Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2016 2022

Research Outputs 2003 2020

  • 162 Citations
  • 9 h-Index
  • 15 Article
  • 1 Meeting abstract
  • 1 Letter
Cell signaling
Enzyme-Linked Immunosorbent Assay

An orthogonal amber initiator tRNA functions similarly across diverse Escherichia coli laboratory strains

Vincent, R., Yiasemides, P. & Jaschke, P., 1 May 2019, In : Matters. p. 1-11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
RNA, Transfer, Met
Terminator Codon
Initiator Codon
Escherichia coli

Building better bacteriophage with biofoundries to combat antibiotic-resistant bacteria

Weynberg, K. D. & Jaschke, P. R., 20 Nov 2019, In : PHAGE: Therapy, Applications, and Research.

Research output: Contribution to journalArticleResearchpeer-review

Synthetic Biology
Anti-Bacterial Agents
Microbial Drug Resistance

Definitive demonstration by synthesis of genome annotation completeness

Jaschke, P. R., Dotson, G. A., Hung, K. S., Liu, D. & Endy, D., 26 Nov 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 48, p. 24206-24213 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Open Reading Frames
Essential Genes
Computational Biology

Measuring amber initiator tRNA orthogonality in a genomically recoded organism

Vincent, R. M., Wright, B. W. & Jaschke, P. R., 2019, In : ACS Synthetic Biology. 8, 4, p. 675-685 11 p.

Research output: Contribution to journalLetterResearchpeer-review

RNA, Transfer, Met
Terminator Codon
Amino Acid-Specific Transfer RNA