Projects per year
Personal profile
Biography
I am a Senior Lecturer (equivalent to Associate Professor in the USA) in Synthetic Biology in the School of Natural Sciences in the Faculty of Science and Engineering and an Associate Investigator in the Centre of Excellence in Synthetic Biology. I completed a PhD in Microbiology and Immunology at the University of British Columbia and an NSERC-funded postdoctoral fellowship in the Bioengineering Department at Stanford University before joining Macquarie University.
Specialties and keywords: Synthetic Biology, Molecular Biology, Genome Engineering, Bacteriophages, Phage Therapy, Antimicrobial Resistance, tRNA, Start Codons, Initiation Codons, Next-Generation Sequencing, Proteomics.
Research interests
My lab is now researching a range of topics in synthetic biology, microbiology, and virology. In particular we are working towards:
Enhancing Phage Therapy
How can we use natural and engineered bacterial viruses (phage) as therapeutics to address the global problem of antibiotic resistant bacteria? We are working to improve phage by using next-generation CRISPR methods to engineer T4 and T7 phages for therapeutic use against uropathogenic E. coli, and other pathogenic bacteria.
Overlapping Genes
Why are nearly 25% of genes in most genomes overlapping? What functional roles do they play, and can we use artificial gene overlaps to slow evolution of engineered systems?
Altered Genetic Codes
How can new genetic codes be used to slow evolution, biocontain GMOs, create orthogonal translation control systems, and add new chemistry to proteins?
Teaching
BMOL3201/6231: Advanced Biochemistry & Cell Biology (2016 - Present)
Unit Convenor and Instructor
Final year undergraduate level lecture and laboratory course
MOLS8411: Molecular Genomics Analysis and Design (2020 - Present)
Unit Convenor, Curriculum Designer, and Instructor
Masters of Biotechnology level unit
Lecture and workshops
MOLS7012: Synthetic Biology (2016 - Present)
Unit Convenor and Instructor
Masters of Research level
Workshops
MOLS7911: Laboratory Skills for Molecular Science Research (2017 - Present)
Instructor for synthetic biology computational lab skills module
Masters of Research level unit
Workshops
BMOL3401: Applied and Medical Microbiology (2020 - Present)
Guest Lecturer on Acellular Pathogens and Person to Person Viral Disease
BMOL2401/6401: Microbiology and Molecular Biology (2016 - Present)
Guest Lecturer on Virus Biology
Research student supervision
As of December 2024, I have been primary supervisor for 9 Masters of Research students (7 completed) and 8 Ph.D. students (4 completed). Alumni from the lab have gone on to roles at: EnGeneic, Hydgene Renewables, Altos Labs, Baxter Healthcare, and Harvard Medical School
We are always looking for Masters of Research (MRes) and PhD students. Please get in touch if you are interested in what the lab is working on and you think your background would be a good fit.
Fingerprint
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International Genetically Engineered Machine (iGEM) Competition
Brown, L. (Primary Chief Investigator), Willows, R. (Other) & Jaschke, P. (Other)
15/05/17 → …
Project: Research
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Biomolecular Discovery and Design Research Centre
Packer, N. (Primary Chief Investigator), Paulsen, I. (Chief Investigator), Nevalainen, H. (Chief Investigator), Haynes, P. (Chief Investigator), Molloy, M. (Chief Investigator), Atwell, B. (Chief Investigator), Barron, A. (Chief Investigator), Beggs, P. (Chief Investigator), Bergquist, P. L. (Chief Investigator), Brown, L. (Chief Investigator), Cornish, J. (Chief Investigator), Chung, R. (Chief Investigator), De Deene, Y. (Chief Investigator), Garcia-Bennett, A. (Chief Investigator), Gillings, M. (Chief Investigator), Goodchild, A. (Chief Investigator), Guillemin, G. (Chief Investigator), Hallinan, J. (Chief Investigator), Hose, G. (Chief Investigator), Jaschke, P. (Chief Investigator), Mabbutt, B. (Chief Investigator), Raftos, D. (Chief Investigator), Ranganathan, S. (Chief Investigator), Sofronov, G. (Chief Investigator), Sunna, A. (Chief Investigator), Tetu, S. (Chief Investigator), Andersen, M. (Chief Investigator), Willows, R. (Chief Investigator), Ahn, C. (Associate Investigator), Breen, E. (Associate Investigator), Campbell, M. (Associate Investigator), Care, A. (Associate Investigator), Cordina, N. (Associate Investigator), Curach, N. (Associate Investigator), Everest Dass, A. (Associate Investigator), Elbourne, L. (Associate Investigator), Goold, H. (Associate Investigator), Hassan, K. (Associate Investigator), Kautto, L. (Associate Investigator), Krisp, C. (Associate Investigator), Kroukamp, H. (Associate Investigator), Lee, A. (Associate Investigator), Lin, C.-H. (Associate Investigator), Mackie, A. (Associate Investigator), McKay, M. (Associate Investigator), McQuade, L. (Associate Investigator), Mirzaei, M. (Associate Investigator), Mohamedali, A. (Associate Investigator), Ostrowski, M. (Associate Investigator), Parker, L. (Associate Investigator), Pascovici, D. (Associate Investigator), Penesyan, A. (Associate Investigator), Shah, B. (Associate Investigator), Sun, A. (Associate Investigator), Thompson, E. (Associate Investigator) & Williams, T. (Associate Investigator)
1/01/17 → …
Project: Research
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MQRIS Large 2023: Nano-flow Cytometry Facility
Wang, Y. (Primary Chief Investigator), Rodger, A. (Chief Investigator), Garcia-Bennett, A. (Chief Investigator), Sunna, A. (Chief Investigator), Cain, A. (Chief Investigator), Ponton, F. (Chief Investigator), Palmisano, G. (Chief Investigator), Thaysen-Andersen, M. (Chief Investigator), Packer, N. (Chief Investigator), Jaschke, P. (Chief Investigator), Inglis, D. (Chief Investigator), Li, M. (Chief Investigator), Nasiri, N. (Chief Investigator), Wu, S. (Chief Investigator), Lu, Y. (Chief Investigator), Volz, T. (Chief Investigator), Shklovskaya, E. (Chief Investigator), Zou, A. (Chief Investigator), Rizos, H. (Chief Investigator), Shi, B. (Chief Investigator), Yang, S. (Chief Investigator), Guller, A. (Chief Investigator) & Tavakkoliyaraki, M. (Chief Investigator)
16/11/22 → 15/11/23
Project: Research
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MQRIS S 2022: High-throughput Phenotyping Platform for PC2 organisms
Semenec, L. (Primary Chief Investigator), Cain, A. (Chief Investigator), Paulsen, I. (Chief Investigator), Hewawasam Gamage, H. (Chief Investigator), Tetu, S. (Chief Investigator), Jaschke, P. (Chief Investigator), Ponton, F. (Chief Investigator) & Maselko, M. (Chief Investigator)
1/01/22 → 31/12/22
Project: Research
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Treatment of multi-drug resistant infections using a novel, rapid and customised synthetic phage therapy platform
Jaschke, P. (Primary Chief Investigator), Weynberg, K. (Chief Investigator), Holowko, M. (Associate Investigator), Barr, J. (Associate Investigator) & Mimee, M. (Associate Investigator)
1/05/20 → 30/04/23
Project: Other
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Improved in silico and in vitro methods for Escherichia coli LPS outer core typing
Trofimova, E., Westerman, R. P. & Jaschke, P. R., 2025, In: Microbial Genomics. 11, 9, p. 1-14 14 p., 001506.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
An improved method for eliminating or creating intragenic bacterial promoters
Trofimova, E., Logel, D. Y. & Jaschke, P. R., 2024, Synthetic Biology: Methods and Protocols. Braman, J. C. (ed.). 2nd ed. New York: Springer, Springer Nature, p. 199-207 9 p. (Methods in Molecular Biology; vol. 2760).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
2 Citations (Scopus) -
Designing a simple and efficient phage biocontainment system using the amber suppressor initiator tRNA
Tsoumbris, P. R., Vincent, R. M. & Jaschke, P. R., Dec 2024, In: Archives of Virology. 169, 12, p. 1-12 12 p., 248.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Discovery and characterisation of new phage targeting uropathogenic Escherichia coli
Asgharzadeh Kangachar, S., Logel, D. Y., Trofimova, E., Zhu, H. X., Zaugg, J., Schembri, M. A., Weynberg, K. D. & Jaschke, P. R., Sept 2024, In: Virology. 597, p. 1-11 11 p., 110148.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)50 Downloads (Pure) -
Exploring virus-host-environment interactions in a chemotrophic-based underground estuary
Ghaly, T. M., Focardi, A., Elbourne, L. D. H., Sutcliffe, B., Humphreys, W. F., Jaschke, P. R., Tetu, S. G. & Paulsen, I. T., 30 Jan 2024, In: Environmental Microbiome. 19, 1, p. 1-13 13 p., 9.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)82 Downloads (Pure)
Prizes
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Inter-Departmental Collaboration - [EX]plore Conference Organising Committee
Spence, D. (Recipient), De Marco, O. (Recipient), Jiang, I. (Recipient), Lin, H. (Recipient), Smith, C. (Recipient), Jaschke, P. (Recipient), Hurst, S. (Recipient), Fernandes Erickson, M. (Recipient), Rhee, K. (Recipient), Sharpless, K. (Recipient), Aboud, J. (Recipient), Er, J. (Recipient) & Pallesen, M. (Recipient), 8 Dec 2022
Prize: Other distinction
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People's Choice Award – BioInnovation Initiative Conference
Jaschke, P. (Recipient), 14 Nov 2024
Prize: Other distinction
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Using synthetic biology to decouple coding sequences and translation initiation
Jaschke, P. (Speaker)
26 Sept 2024Activity: Talk or presentation › Invited talk
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Using synthetic biology to understand and improve phage
Jaschke, P. (Speaker)
30 Sept 2023Activity: Talk or presentation › Invited talk
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Refactoring Phage: Lessons and Potential [Competitively Selected Presentation]
Jaschke, P. (Speaker)
14 Sept 2021Activity: Talk or presentation › Presentation
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Manipulating bacteriophage genomes and host-range on the way to next-generation antimicrobials [Invited Talk]
Jaschke, P. (Speaker)
Nov 2021Activity: Talk or presentation › Invited talk
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Engineering phage ΦX174: Lessons and Potential [Invited Talk]
Jaschke, P. (Speaker)
Oct 2021Activity: Talk or presentation › Invited talk