Projects per year
Personal profile
Biography
Professor Richard Kefford AM MB BS PhD FRACP FAHMS is Emeritus Professor and former Head of Department, Department of Clinical Medicine at Macquarie University, Sydney, Faculty Member at Melanoma Institute Australia, Consultant Emeritus in Medical Oncology at Westmead Hospital, Sydney, and Honorary Professor of Medicine, University of Sydney. He is an internationally acclaimed melanoma researcher and a national leader in academic medicine and medical research with a life-long record of commitment and service to Australian medical research, peer review, professional training and mentoring and community education in oncology. He contributed to the mapping and characterisation of the major melanoma susceptibility genes and the development of international guidelines on genetic testing of those at high melanoma risk. He played a pivotal role in the development of life-extending drug treatments now used as standard-of-care for melanoma, including the first-time in human trial of dabrafenib, the pioneering use of dabrafenib and trametinib for patients with brain metastases, and the Phase 1 clinical trial of pembrolizumab.
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Collaborations and top research areas from the last five years
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IPATunity170: A Phase III, Double-Blind, Placebo-Controlled, Randomized Study Of Ipatasertib In Combination With Atezolizumab And Paclitaxel As A Treatment For Patients With Locally Advanced Unresectable Or Metastatic Triple-Negative Breast Cancer
Kefford, R., Chapman, N., Parshionikar, A. & Rajasekharan Nair, A.
22/11/19 → 30/09/24
Project: Other
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IPATunity170: A Phase III, Double-Blind, Placebo-Controlled, Randomized Study Of Ipatasertib In Combination With Atezolizumab And Paclitaxel As A Treatment For Patients With Locally Advanced Unresectable Or Metastatic Triple-Negative Breast Cancer
Kefford, R., Chapman, N., Parshionikar, A. & Rajasekharan Nair, A.
22/11/19 → 30/09/24
Project: Other
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IPATunity170: A Phase III, Double-Blind, Placebo-Controlled, Randomized Study Of Ipatasertib In Combination With Atezolizumab And Paclitaxel As A Treatment For Patients With Locally Advanced Unresectable Or Metastatic Triple-Negative Breast Cancer
Kefford, R., Chapman, N., Parshionikar, A. & Rajasekharan Nair, A.
22/11/19 → 30/09/24
Project: Other
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IPATunity170: A Phase III, Double-Blind, Placebo-Controlled, Randomized Study Of Ipatasertib In Combination With Atezolizumab And Paclitaxel As A Treatment For Patients With Locally Advanced Unresectable Or Metastatic Triple-Negative Breast Cancer
Kefford, R., Chapman, N., Parshionikar, A. & Rajasekharan Nair, A.
22/11/19 → 30/09/24
Project: Other
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Differential effects of MAPK inhibition on immune activity determine melanoma response
Lim, E., Rizos, H. & Kefford, R.
17/04/17 → …
Project: Research
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IFN-γ signaling sensitizes melanoma cells to BH3 mimetics
Ming, Z., Lim, S. Y., Stewart, A., Pedersen, B., Shklovskaya, E., Menzies, A. M., Carlino, M. S., Kefford, R. F., Lee, J. H., Scolyer, R. A., Long, G. V. & Rizos, H., Jul 2023, In: Journal of Investigative Dermatology. 143, 7, p. 1246-1256.e8 19 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Musculoskeletal immune-related adverse events with the use of checkpoint inhibitors in malignancy
Dey, A., Manolios, N., Long, G. V., Carlino, M. S., Kefford, R. & Schrieber, L., May 2022, In: Internal Medicine Journal. 52, 5, p. 818-827 10 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
First‐in‐human, phase I/IIa study of CRLX301, a nanoparticle drug conjugate containing docetaxel, in patients with advanced or metastatic solid malignancies
Piha-Paul, S. A., Thein, K. Z., De Souza, P., Kefford, R., Gangadhar, T., Smith, C., Schuster, S., Zamboni, W. C., Dees, C. E. & Markman, B., Aug 2021, In: Investigational New Drugs. 39, 4, p. 1047-1056 10 p.Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus) -
Management of melanoma brain metastases: evidence-based clinical practice guidelines by Cancer Council Australia
Hong, A. M., Waldstein, C., Shivalingam, B., Carlino, M. S., Atkinson, V., Kefford, R. F., McArthur, G. A., Menzies, A. M., Thompson, J. F. & Long, G. V., 1 Jan 2021, In: European Journal of Cancer. 142, p. 10-17 8 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
Risk factors for melanoma by anatomical site: an evaluation of aetiological heterogeneity
Laskar, R., Ferreiro-Iglesias, A., Bishop, D. T., Iles, M. M., Kanetsky, P. A., Armstrong, B. K., Law, M. H., Goldstein, A. M., Aitken, J. F., Australian Melanoma Family Study Investigators, Leeds Case–Control Study Investigators, Robbins, H. A. & Cust, A. E., Jun 2021, In: British Journal of Dermatology. 184, 6, p. 1085-1093 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)31 Downloads (Pure)
Prizes
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Australian Academy of Health and Medical Sciences Fellowship
Kefford, Richard (Recipient), 2016
Prize: Honorary award
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Award for Translational Oncology Research, Cancer Institute of NSW
Kefford, Richard (Recipient), 2009
Prize
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Florey Fellowship of the Royal Society of London
Kefford, Richard (Recipient), 1983
Prize: Honorary award