• 30094 Citations
  • 76 h-Index
1980 …2022

Research output per year

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Personal profile

Biography

Professor Richard Kefford AM MB BS PhD FRACP is Professor of Cancer Medicine and former Head of Department, Department of Clinical Medicine at Macquarie University, Sydney and Co-Director of Research at Melanoma Institute Australia. He is an internationally acclaimed melanoma researcher and a national leader in academic medicine and medical research with a life-long record of commitment and service to Australian medical research, peer review, professional training and mentoring and community education in oncology. He contributed to the mapping and characterisation of the major melanoma susceptibility genes and the development of international guidelines on genetic testing of those at high melanoma risk. He played a pivotal role in the development of life-extending drug treatments now used as standard-of-care for melanoma, including the first-time in human trial of dabrafenib, the pioneering use of dabrafenib and trametinib for patients with brain metastases, and the Phase 1 clinical trial of pembrolizumab.

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Projects

Centre for Research Excellence in Implementation Science in Oncology (CRE-ISO)

Braithwaite, J., Ward, R., Currow, D., Delaney, G., Kefford, R., Olver, I., Karnon, J., Crowe, P., Liauw, W., Westbrook, J., Meiser, B., Tieman, J., Verspoor, K., Ellis, L., Krishnasamy, M., Ayliff, N., Hawkins, N., Hibbert, P., Farnsworth, R. & Clay-Williams, R.

1/12/1730/11/22

Project: Other

Acquired resistance to PD1 inhibition in melanoma

Rizos, H., Carlino, M., Kefford, R., Zhang, X. D., Menzies, A. M., Long, G., McGuire, H., Yang, J., Scolyer, R. & De St Groth, B. F.

1/01/17 → …

Project: Research

Determinants of response to immune checkpoint inhibitors in melanoma

Rizos, H., Long, G., Menzies, A. M., Yang, J., Carlino, M., Kefford, R., Scolyer, R., MQRES, M., MQRES 3 (International), M. 3. & De St Groth, B. F.

1/01/17 → …

Project: Research

Molecular determinants of risk, progression and treatment response in melanoma

Kefford, R., Thompson, J., Hersey, P., Mann, G., Scolyer, R., Hayward, N. & Long, G.

1/01/16 → …

Project: Research

Research Outputs

Adjuvant dabrafenib plus trametinib versus placebo in patients with resected, BRAFV600-mutant, stage III melanoma (COMBI-AD): exploratory biomarker analyses from a randomised, phase 3 trial

Dummer, R., Brase, J. C., Garrett, J., Campbell, C. D., Gasal, E., Squires, M., Gusenleitner, D., Santinami, M., Atkinson, V., Mandalà, M., Chiarion-Sileni, V., Flaherty, K., Larkin, J., Robert, C., Kefford, R., Kirkwood, J. M., Hauschild, A., Schadendorf, D. & Long, G. V., 1 Mar 2020, In : The Lancet Oncology. 21, 3, p. 358-372 15 p.

Research output: Contribution to journalArticle

  • 1 Citation (Scopus)
    Open Access
    File
  • Long-term outcomes in patients with BRAF V600-mutant metastatic melanoma receiving dabrafenib monotherapy: analysis from phase 2 and 3 clinical trials

    Hauschild, A., Ascierto, P. A., Schadendorf, D., Grob, J. J., Ribas, A., Kiecker, F., Dutriaux, C., Demidov, L. V., Lebbé, C., Rutkowski, P., Blank, C. U., Gutzmer, R., Millward, M., Kefford, R., Haas, T., D'Amelio, A., Gasal, E., Mookerjee, B. & Chapman, P. B., 1 Jan 2020, In : European Journal of Cancer. 125, p. 114-120 7 p.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)
  • Analysis of the whole-exome sequencing of tumor and circulating tumor DNA in metastatic melanoma

    Diefenbach, R. J., Lee, J. H., Strbenac, D., Yang, J. Y. H., Menzies, A. M., Carlino, M. S., Long, G. V., Spillane, A. J., Stretch, J. R., Saw, R. P. M., Thompson, J. F., Ch'ng, S., Scolyer, R. A., Kefford, R. F. & Rizos, H., 29 Nov 2019, In : Cancers. 11, 12, p. 1-14 14 p., 1905.

    Research output: Contribution to journalArticle

    Open Access
    File