Projects per year
Personal profile
Biography
Professor Rupert Leong is a Senior Staff Specialist gastroenterologist, Director of Endoscopy and Head of the Inflammatory Bowel Disease Services at Concord Hospital, Clinical Professor of Medicine at University of Sydney and Macquarie University, Sydney Australia. He was formally the Director of Gastroenterology at Bankstown Hospital, Conjoint Professor of Medicine at UNSW and Career Development Fellow (level 2 clinical) of the NHMRC. Prof Leong has made a substantial contribution to research with over 210 high quality scientific journals publications. Amongst these are senior authorship of national and international consensus guidelines in both Australia and in Asia. He is section editor of the Journal of Gastroenterology and Hepatology and on the international editorial boards of the American Journal of Gastroenterology, Alimentary Pharmacology and Therapeutics and Gastrointestinal Endoscopy.
Prof Leong is an executive member of a number of government bodies including the Agency for Clinical Innovation of NSW Health nominated for expertise in IBD and the Cancer Council of Australia Working Party on the revision of the clinical practice guidelines for colonoscopy and colorectal cancer, leading the section on surveillance colonoscopy in inflammatory bowel disease. Professor Leong was awarded the American Gastroenterological Association Fellowship by invitation on the basis of research excellence in 2012. He is the founding director of IBD Sydney, IBD School and IBD Masterclass.
As a clinician, Prof Leong is widely recognized for his endoscopy skills especially on the role of advanced imaging techniques and colon cancer diagnostic strategies. His private consultation rooms are at Macquarie University Hospital (Suite 404, 2 Technology Place, Macquarie Uni 98123880) on George St near Town Hall Station (Specialist Medical Services, Level 11, 501 George St, Sydney 83781721). His global reputation has led to speaking engagements and live endoscopy demonstrations around the world including in USA, Germany, China, Hong Kong, Singapore among others. He is a principle supervisor to PhD, MPhil and Masters by Research students and has supervised international gastroenterology fellows from Hong Kong, Singapore, Malaysia, Philippines, Sweden, UK, Wales, Ireland and Northern Ireland.
External positions
Director of IBD School
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Collaborations and top research areas from the last five years
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SIBERITE-2: CTU: A PHASE III, MULTICENTER, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO ASSESS THE EFFICACY AND SAFETY OF INDUCTION THERAPY WITH RO7790121 IN PATIENTS WITH MODERATELY TO SEVERELY ACTIVE CROHN'S DISEASE
Leong, R. (Primary Chief Investigator), Chapman, N. (Clinical Trial Unit Staff), Quinlan, G. (Clinical Trial Unit Staff), TAIDI, G. (Clinical Trial Unit Staff), Martin, L. (Clinical Trial Unit Staff), McHugh, T. (Clinical Trial Unit Staff) & Garcia, M. (Clinical Trial Unit Staff)
19/02/25 → 31/10/29
Project: Research
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CTU: A phase III, multicenter, double-blind, placebo-controlled study to assess the efficacy and safety of induction therapy with RO7790121 in patients with moderately to severely active ulcerative colitis
Leong, R., Chapman, N., Quinlan, G., TAIDI, G., Garcia, M., Armstrong, E. & McHugh, T.
6/11/24 → 28/09/29
Project: Research
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SWIFT: CTU: A Multicenter, Randomized, Double-blind, 2-Part Phase 2 Study to Evaluate the Efficacy and Safety of GS-1427 in Adult Participants With Moderately to Severely Active Ulcerative Colitis (UC)
Leong, R., Martin, L., TAIDI, G., Chapman, N., Quinlan, G., Garcia, M. & Armstrong, E.
14/08/24 → 27/06/29
Project: Research
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SISS: CTU: Switching patients from intravenous to subcutaneous infliximab in inflammatory bowel disease (SISS)
Leong, R., Contacos, C., Chapman, N., TAIDI, G. & Chester, C.
18/01/24 → 23/10/28
Project: Research
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STOPIt: Study of Tofacitinib for the treatment of chronic pouchitis (StopIt)
Leong, R., Chapman, N. & Chester, C.
12/05/22 → 11/05/27
Project: Research
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Anti-TL1A antibody, afimkibart, in moderately-to-severely active ulcerative colitis (TUSCANY-2): a multicentre, double-blind, treat-through, multi-dose, randomised, placebo-controlled, phase 2b trial
Danese, S., Allegretti, J. R., Schreiber, S., Peyrin-Biroulet, L., Jairath, V., D'Haens, G., Kierkuś, J., Leong, R. W., Yarur, A. J., Vincent, M. S., Banerjee, A., Chandra, D. E., Peeva, E., Neelakantan, S., Hung, K. E., McBride, J. M., Bojic, D., Lasch, K., Schiffman, C. & Feagan, B. G., Oct 2025, In: The Lancet Gastroenterology and Hepatology. 10, 10, p. 882-895 14 p.Research output: Contribution to journal › Article › peer-review
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Clinical trial: Association between early disease clearance and long-term outcomes - 4-year results from the Phase 3 UNIFI Study of Ustekinumab in Ulcerative Colitis
Danese, S., Leong, R. W., Sands, B. E., Ma, T., Marano, C. & Peyrin-Biroulet, L., Sept 2025, In: Alimentary Pharmacology and Therapeutics. 62, 5, p. 483-492 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Downloads (Pure) -
Comprehensive care of ulcerative colitis: new treatment strategies
Chaemsupaphan, T., Arzivian, A. & Leong, R. W., 3 Oct 2025, In: Expert Review of Gastroenterology and Hepatology. 19, 10, p. 1063-1079 17 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
Consensus statements on assessments and vaccinations prior to commencement of advanced therapies for the treatment of inflammatory bowel diseases
Leong, R. W., Sakiris, A., Arzivian, A., Chetwood, J. D., Chaemsupaphan, T., Sparrow, M. P., Kamm, M. A., Kariyawasam, V. & Australian IBD Consensus Working Group, Jan 2025, In: Alimentary Pharmacology and Therapeutics. 61, 1, p. 132-144 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)14 Downloads (Pure) -
Definitions, diagnosis, and management of postoperative recurrence in Crohn's disease patients with permanent ileostomy: a systematic review and meta-Analysis
Endpoint Development for Ostomy Clinical Trials (EndO-Trial) Consortium, 4 Apr 2025, In: Journal of Crohn's and Colitis. 19, 4, p. 1-15 15 p., jjaf041.Research output: Contribution to journal › Review article › peer-review
1 Citation (Scopus)
Prizes
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Trans-Tasman Lecturer of RACP and NZ Society of Gastroenterology
Leong, R. (Recipient), 1 Jan 2015
Prize: Honorary award
Press/Media
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Assisted reproduction awareness needed for IBD patients
Rupert Leong & Robyn Laube
27/10/21
1 item of Media coverage
Press/Media: Expert Comment
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Professor Rupert Leong: patient preference should guide biologic choice
20/09/18
1 item of Media coverage
Press/Media: Expert Comment