Sakkie Pretorius

Professor

  • 12941 Citations
  • 56 h-Index
1983 …2020

Research output per year

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Research Outputs

2020

Bio-informational futures: the convergence of artificial intelligence and synthetic biology

Dixon, T. A., Curach, N. & Pretorius, I. S., 4 Mar 2020, In : EMBO Reports. 21, 3, p. 1-5 5 p., e50036.

Research output: Contribution to journalArticle

Blending wine yeast phenotypes with the aid of CRISPR DNA editing technologies

van Wyk, N., Kroukamp, H., Espinosa, M. I., von Wallbrunn, C., Wendland, J. & Pretorius, I. S., 2 Jul 2020, In : International Journal of Food Microbiology. 324, 7 p., 108615.

Research output: Contribution to journalArticle

Tasting the terroir of wine yeast innovation

Pretorius, I. S., Feb 2020, In : FEMS Yeast Research. 20, 1, p. 1-22 22 p., foz084.

Research output: Contribution to journalReview article

Open Access
File
3 Citations (Scopus)
174 Downloads (Pure)
Open Access
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1 Downloads (Pure)
2019
Open Access
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18 Downloads (Pure)

Building a global alliance of biofoundries

Hillson, N. J., Caddick, M., Cai, Y., Carrasco, J. A., Chang, M. W., Curach, N. C., Bell, D. J., Le Feuvre, R., Friedman, D. C., Fu, X., Gold, N. D., Herrgård, M. J., Holowko, M. B., Johnson, J. R., Johnson, R. A., Keasling, J. D., Kitney, R. I., Kondo, A., Liu, C., Martin, V. J. J. & 16 others, Menolascina, F., Ogino, C., Patron, N. J., Pavan, M., Poh, C. L., Pretorius, I. S., Rosser, S. J., Scrutton, N. S., Storch, M., Tekotte, H., Travnik, E., Vickers, C. E., Yew, W. S., Yuan, Y., Zhao, H. & Freemont, P. S., 9 May 2019, In : Nature Communications. 10, 1, p. 1-4 4 p., 2040.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
38 Downloads (Pure)
Open Access
File
2 Citations (Scopus)
10 Downloads (Pure)

Saccharomyces cerevisiae

Belda, I., Ruiz, J., Santos, A., Van Wyk, N. & Pretorius, I. S., Dec 2019, In : Trends in Genetics. 35, 12, p. 956-957 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The whiff of wine yeast innovation: strategies for enhancing aroma production by yeast during wine fermentation

Van Wyk, N., Grossmann, M., Wendland, J., Von Wallbrunn, C. & Pretorius, I. S., 11 Dec 2019, In : Journal of Agricultural and Food Chemistry. 67, 49, p. 13496-13505 10 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Yeast 2.0 - synthetic genome engineering pioneers new possibilities for wine yeast research

Pretorius, I. S., 2019, Yeasts in the production of wine. Romano, P., Ciani, M. & Fleet, G. H. (eds.). New York: Springer, Springer Nature, p. 211-227 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2018

Applications of yeast synthetic biology geared towards the production of biopharmaceuticals

Walker, R. S. K. & Pretorius, I. S., Jul 2018, In : Genes. 9, 7, p. 1-22 22 p., 340.

Research output: Contribution to journalReview article

Open Access
File
9 Citations (Scopus)
335 Downloads (Pure)

Population sequencing reveals clonal diversity and ancestral inbreeding in the grapevine cultivar Chardonnay

Roach, M. J., Johnson, D. L., Bohlmann, J., van Vuuren, H. J. J., Jones, S. J. M., Pretorius, I. S., Schmidt, S. A. & Borneman, A. R., 20 Nov 2018, In : PLoS Genetics. 14, 11, p. 1-24 24 p., e1007807.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
10 Downloads (Pure)

Systems-based approaches enable identification of gene targets which improve the flavour profile of low-ethanol wine yeast strains

Varela, C., Schmidt, S. A., Borneman, A. R., Pang, C. N. I., Krömerx, J. O., Khan, A., Song, X., Hodson, M. P., Solomon, M., Mayr, C. M., Hines, W., Pretorius, I. S., Baker, M. S., Roessner, U., Mercurio, M., Henschke, P. A., Wilkins, M. R. & Chambers, P. J., 1 Sep 2018, In : Metabolic Engineering. 49, p. 178-191 14 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The smell of synthetic biology: engineering strategies for aroma compound production in yeast

van Wyk, N., Kroukamp, H. & Pretorius, I. S., Sep 2018, In : Fermentation. 4, 3, p. 1-18 18 p., 54.

Research output: Contribution to journalReview article

Open Access
File
7 Citations (Scopus)
98 Downloads (Pure)

Yeast 2.0—connecting the dots in the construction of the world's first functional synthetic eukaryotic genome

Pretorius, I. S. & Boeke, J. D., 1 Jun 2018, In : FEMS Yeast Research. 18, 4, p. 1-15 15 p., foy032.

Research output: Contribution to journalArticle

Open Access
File
28 Citations (Scopus)
40 Downloads (Pure)
2017
Open Access
File
33 Downloads (Pure)

Solving yeast jigsaw puzzles over a glass of wine: Synthetic genome engineering pioneers new possibilities for wine yeast research

Pretorius, I. S., 1 Nov 2017, In : EMBO Reports. 18, 11, p. 1875-1884 10 p.

Research output: Contribution to journalComment/opinion

Open Access
File
7 Citations (Scopus)
14 Downloads (Pure)

Synthetic biology stretching the realms of possibility in wine yeast research

Jagtap, U. B., Jadhav, J. P., Bapat, V. A. & Pretorius, I. S., 3 Jul 2017, In : International Journal of Food Microbiology. 252, p. 24-34 11 p.

Research output: Contribution to journalReview article

10 Citations (Scopus)

Synthetic genome engineering forging new frontiers for wine yeast

Pretorius, I. S., 2 Jan 2017, In : Critical Reviews in Biotechnology. 37, 1, p. 112-136 25 p.

Research output: Contribution to journalReview article

18 Citations (Scopus)

Yeast's balancing act between ethanol and glycerol production in low-alcohol wines

Goold, H. D., Kroukamp, H., Williams, T. C., Paulsen, I. T., Varela, C. & Pretorius, I. S., 1 Mar 2017, In : Microbial Biotechnology. 10, 2, p. 264-278 15 p.

Research output: Contribution to journalReview article

Open Access
File
42 Citations (Scopus)
38 Downloads (Pure)
2016

Heterologous production of raspberry ketone in the wine yeast Saccharomyces cerevisiae via pathway engineering and synthetic enzyme fusion

Lee, D., Lloyd, N. D. R., Pretorius, I. S. & Borneman, A. R., 4 Mar 2016, In : Microbial Cell Factories. 15, p. 1-7 7 p., 49.

Research output: Contribution to journalArticle

Open Access
File
35 Citations (Scopus)
17 Downloads (Pure)

Synthetic Evolution of Metabolic Productivity Using Biosensors

Williams, T. C., Pretorius, I. S. & Paulsen, I. T., 1 May 2016, In : Trends in Biotechnology. 34, 5, p. 371-381 11 p.

Research output: Contribution to journalReview article

50 Citations (Scopus)
2015

Designing wine yeast for the future

Pretorius, I. S., Curtin, C. D. & Chambers, P. J., 2015, Advances in Fermented Foods and Beverages: Improving Quality, Technologies and Health Benefits. Holzapfel, W. (ed.). Cambridge: Woodhead Publishing, p. 197-226 30 p. (Woodhead Publishing Series in Food Science, Technology and Nutrition; vol. 265).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Elucidating whole-genome design principles using synthetic genomics: The Yeast 2.0 project

Williams, T. C., Wightman, E. L. I., Daniel, E. L., Kroukamp, H., Nevalainen, H. K. M., Paulsen, I. T. & Pretorius, I. S., 2015, Proceedings of the 6th Australasian Conference on Yeast: Products and Discovery. Grbin, P. R. & Chambers, P. (eds.). 1 p. 3-1

Research output: Chapter in Book/Report/Conference proceedingConference abstract

Genomic insights into the Saccharomyces sensu stricto complex

Borneman, A. R. & Pretorius, I. S., 1 Feb 2015, In : Genetics. 199, 2, p. 281-291 11 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Influence of diammonium phosphate addition to fermentation on wine biologicals

Vilanova, M., Pretorius, I. S. & Henschke, P. A., 2015, Processing and Impact on Active Components in Food. Preedy, V. (ed.). London: Academic Press, p. 483-491 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)
2014

Festive foods

Pretorius, I. S., 1 Nov 2014, In : FEMS Microbiology Letters. 360, 2, p. 85-86 2 p.

Research output: Contribution to journalComment/opinion

Genomic insights into the evolution of industrial yeast species Brettanomyces bruxellensis

Curtin, C. D. & Pretorius, I. S., 1 Nov 2014, In : FEMS Yeast Research. 14, 7, p. 997-1005 9 p.

Research output: Contribution to journalReview article

28 Citations (Scopus)

Not your ordinary yeast: Non-Saccharomyces yeasts in wine production uncovered

Jolly, N. P., Varela, C. & Pretorius, I. S., Mar 2014, In : FEMS Yeast Research. 14, 2, p. 215-237 23 p.

Research output: Contribution to journalReview article

332 Citations (Scopus)

Whole-genome comparison reveals novel genetic elements that characterize the genome of industrial strains of Saccharomyces cerevisiae

Borneman, A. R., Desany, B. A., Riches, D., Affourtit, J. P., Forgan, A. H., Pretorius, I. S., Egholm, M. & Chambers, P. J., 2014, Investigations in yeast functional genomics and molecular biology. Eckwahl, M. (ed.). Toronto: Apple Academic Press, p. 339-362 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Wine, beer and cider: Unravelling the aroma profile

Gamero, A., Ferreira, V., Pretorius, I. S. & Querol, A., 2014, Molecular Mechanisms in Yeast Carbon Metabolism. Piškur, J. & Compagno, C. (eds.). Berlin; Heidelberg: Springer, Springer Nature, p. 261-297 37 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Citations (Scopus)
2013

At the cutting-edge of grape and wine biotechnology

Borneman, A. R., Schmidt, S. A. & Pretorius, I. S., Apr 2013, In : Trends in Genetics. 29, 4, p. 263-271 9 p.

Research output: Contribution to journalReview article

24 Citations (Scopus)

Comparative genomics: A revolutionary tool for wine yeast strain development

Borneman, A. R., Pretorius, I. S. & Chambers, P. J., Apr 2013, In : Current Opinion in Biotechnology. 24, 2, p. 192-199 8 p.

Research output: Contribution to journalReview article

24 Citations (Scopus)

Novel wine yeast with mutations in YAP1 that produce less acetic acid during fermentation

Cordente, A. G., Cordero-Bueso, G., Pretorius, I. S. & Curtin, C. D., Jan 2013, In : FEMS Yeast Research. 13, 1, p. 62-73 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2012

A breeding strategy to harness flavor diversity of Saccharomyces interspecific hybrids and minimize hydrogen sulfide production

Bizaj, E., Cordente, A. G., Bellon, J. R., Raspor, P., Curtin, C. D. & Pretorius, I. S., Jun 2012, In : FEMS Yeast Research. 12, 4, p. 456-465 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Controlling the highs and the lows of alcohol in wine

Stockley, C. S., Varela, C., Coulter, A., Dry, P. R., Francis, I. L., Muhlack, R. & Pretorius, I. S., Aug 2012, Wine: Types, Production and Health. Peeters, A. S. (ed.). New York: Nova Science Publishers, p. 281-299 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

De-novo assembly and analysis of the heterozygous triploid genome of the wine spoilage yeast dekkera bruxellensis AWRI1499

Curtin, C. D., Borneman, A. R., Chambers, P. J. & Pretorius, I. S., 28 Mar 2012, In : PLoS ONE. 7, 3, p. 1-10 10 p., e33840.

Research output: Contribution to journalArticle

Open Access
File
81 Citations (Scopus)
15 Downloads (Pure)

Effect of ammonium nitrogen supplementation of grape juice on wine volatiles and non-volatiles composition of the aromatic grape variety Albarino

Vilanova, M., Siebert, T. E., Varela, C., Pretorius, I. S. & Henschke, P. A., 1 Jul 2012, In : Food Chemistry. 133, 1, p. 124-131 8 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Evaluation of gene modification strategies for the development of low-alcohol-wine Yeasts

Varela, C., Kutyna, D. R., Solomon, M. R., Black, C. A., Borneman, A., Henschke, P. A., Pretorius, I. S. & Chambers, P. J., Sep 2012, In : Applied and Environmental Microbiology. 78, 17, p. 6068-6077 10 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Flavour-active wine yeasts

Cordente, A. G., Curtin, C. D., Varela, C. & Pretorius, I. S., Nov 2012, In : Applied Microbiology and Biotechnology. 96, 3, p. 601-618 18 p.

Research output: Contribution to journalReview article

Open Access
File
72 Citations (Scopus)
44 Downloads (Pure)

The genome sequence of the wine yeast VIN7 reveals an allotriploid hybrid genome with Saccharomyces cerevisiae and Saccharomyces kudriavzevii origins

Borneman, A. R., Desany, B. A., Riches, D., Affourtit, J. P., Forgan, A. H., Pretorius, I. S., Egholm, M. & Chambers, P. J., Feb 2012, In : FEMS Yeast Research. 12, 1, p. 88-96 9 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

The Winemaker's bug: From ancient wisdom to opening new vistas with frontier yeast science

Pretorius, I. S., Curtin, C. D. & Chambers, P. J., Jul 2012, In : Bioengineered Bugs. 3, 3, p. 147-156 10 p.

Research output: Contribution to journalReview article

31 Citations (Scopus)

Wine-Omics: new platforms for the improvement of yeast strains and wine quality

Ting, C. S. C., Borneman, A. R. & Pretorius, I. S., 2012, OMICS technologies: tools for food science. Benkeblia, N. (ed.). Boca Raton: CRC Press, Taylor & Francis Group, p. 339-365 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2011

Whole-genome comparison reveals novel genetic elements that characterize the genome of industrial strains of saccharomyces cerevisiae

Borneman, A. R., Desany, B. A., Riches, D., Affourtit, J. P., Forgan, A. H., Pretorius, I. S., Egholm, M. & Chambers, P. J., 7 Feb 2011, In : PLoS Genetics. 7, 2, p. 1-10 10 p., e1001287.

Research output: Contribution to journalArticle

Open Access
File
183 Citations (Scopus)
9 Downloads (Pure)
2010

Fermenting knowledge: The history of winemaking, science and yeast research

Chambers, P. J. & Pretorius, I. S., Dec 2010, In : EMBO Reports. 11, 12, p. 914-920 7 p.

Research output: Contribution to journalReview article

50 Citations (Scopus)

Preliminary evaluation of infrared spectroscopy for the differentiation of Brettanomyces bruxellensis strains isolated from red wines

Oelofse, A., Malherbe, S., Pretorius, I. S. & Du Toit, M., 15 Oct 2010, In : International Journal of Food Microbiology. 143, 3, p. 136-142 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

The effect of multiple yeasts co-inoculations on Sauvignon Blanc wine aroma composition, sensory properties and consumer preference

King, E. S., Kievit, R. L., Curtin, C., Swiegers, J. H., Pretorius, I. S., Bastian, S. E. P. & Leigh Francis, I., 1 Oct 2010, In : Food Chemistry. 122, 3, p. 618-626 9 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Wine fermentation

Curtin, C., Chambers, P. & Pretorius, S., 2010, Encyclopedia of biotechnology in agriculture and food. Heldman, D. R., Wheeler, M. B. & Hoover, D. G. (eds.). London: Taylor & Francis, p. 689-694 6 p.

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary/reference book

2009

Differential synthesis of fermentative aroma compounds of two related commercial wine yeast strains

Molina, A. M., Guadalupe, V., Varela, C., Swiegers, J. H., Pretorius, I. S. & Agosin, E., 15 Nov 2009, In : Food Chemistry. 117, 2, p. 189-195 7 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Establishing a risk-assessment process for release of genetically modified wine yeast into the environment

Schoeman, H., Wolfaardt, G. M., Botha, A., Van Rensburg, P. & Pretorius, I. S., Aug 2009, In : Canadian Journal of Microbiology. 55, 8, p. 990-1002 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)