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Research Outputs 2009 2019

  • 565 Citations
  • 9 h-Index
  • 10 Article
  • 2 Meeting abstract
  • 1 Comment/opinion
  • 1 Review article
2019

Kynurenine 3-monooxygenase activity in human primary neurons and effect on cellular bioenergetics identifies new neurotoxic mechanisms

Castellano-Gonzalez, G., Jacobs, K. R., Don, E., Cole, N. J., Adams, S., Lim, C. K., Lovejoy, D. B. & Guillemin, G. J., Apr 2019, In : Neurotoxicity Research. 35, 3, p. 530-541 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Kynurenine 3-Monooxygenase
Kynurenine
Human Activities
Energy Metabolism
Quinolinic Acid
2015

Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2

Gurgis, F. M. S., Åkerfeldt, M. C., Heng, B., Wong, C., Adams, S., Guillemin, G. J., Johns, T. G., Chircop, M. & Munoz, L., 2015, In : Cell death discovery. 1, p. 1-11 11 p., 15028.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Glioblastoma
Protein Kinase Inhibitors
Protein Kinases
Tubulin
Phosphotransferases
2014

Involvement of the kynurenine pathway in human glioma pathophysiology

Adams, S., Teo, C., McDonald, K. L., Zinger, A., Bustamante, S., Lim, C. K., Sundaram, G., Braidy, N., Brew, B. J. & Guillemin, G. J., 17 Oct 2014, In : PLoS ONE. 9, 11, p. 1-28 28 p., 0112945.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Kynurenine
pathophysiology
kynurenine
Glioma
Indoleamine-Pyrrole 2,3,-Dioxygenase

Quinolinic acid toxicity on oligodendroglial cells: Relevance for multiple sclerosis and therapeutic strategies

Sundaram, G., Brew, B. J., Jones, S. P., Adams, S., Lim, C. K. & Guillemin, G. J., 13 Dec 2014, In : Journal of Neuroinflammation. 11, p. 1-11 11 p., 204.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Quinolinic Acid
Multiple Sclerosis
Kynurenine
Oligodendroglia
Therapeutics
2013

Involvement of the kynurenine pathway in human primary glioma pathophysiology

Adams, S., Teo, C., McDonald, K., Zinger, A., Bustamante, S., Lim, C. K., Braidy, N., Brew, B. J. & Guillemin, G. J., Nov 2013, In : Neuro-Oncology. 15, p. 85-85 1 p.

Research output: Contribution to journalMeeting abstractResearch

The endogenous tryptophan metabolite and NAD(+) precursor quinolinic acid confers resistance of gliomas to oxidative stress

Sahm, F., Oezen, I., Opitz, C. A., Radlwimmer, B., Von Deimling, A., Ahrendt, T., Adams, S., Bode, H. B., Guillemin, G. J., Wick, W. & Platten, M., 1 Jun 2013, In : Cancer Research. 73, 11, p. 3225-3234 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Quinolinic Acid
Glioma
Tryptophan
NAD
Oxidative Stress
2012

Correction: The kynurenine pathway in brain tumor pathogenesis (Cancer Research (2012) 72, (5649-5657))

Adams, S., Braidy, N., Bessede, A., Brew, B. J., Grant, R., Teo, C. & Guillemin, G. J., 15 Dec 2012, In : Cancer Research. 72, 24, p. 6524 1 p.

Research output: Contribution to journalComment/opinionResearchpeer-review

P38 MAPK inhibitors attenuate pro-inflammatory cytokine production and the invasiveness of human U251 glioblastoma cells

Yeung, Y. T., Bryce, N. S., Adams, S., Braidy, N., Konayagi, M., McDonald, K. L., Teo, C., Guillemin, G. J., Grewal, T. & Munoz, L., Aug 2012, In : Journal of Neuro-Oncology. 109, 1, p. 35-44 10 p.

Research output: Contribution to journalArticleResearchpeer-review

p38 Mitogen-Activated Protein Kinases
Glioblastoma
Protein Kinase Inhibitors
Cytokines
Inflammation

The kynurenine pathway in brain tumor pathogenesis

Adams, S., Braidy, N., Bessesde, A., Brew, B. J., Grant, R., Teo, C. & Guillemin, G. J., 15 Nov 2012, In : Cancer Research. 72, 22, p. 5649-5657 9 p.

Research output: Contribution to journalReview articleResearchpeer-review

Kynurenine
Brain Neoplasms
3-Hydroxyanthranilic Acid
Quinolinic Acid
Aryl Hydrocarbon Receptors
2011

Involvement of the kynurenine pathway in human primary glioblastoma pathogenesis

Adams, S., Braidy, N., Teo, C. & Guillemin, G., Nov 2011, In : Neuro-Oncology. 13, p. 69-69 1 p.

Research output: Contribution to journalMeeting abstractResearch

2010

Characterisation of the expression of NMDA receptors in human astrocytes

Lee, M. C., Ting, K. K., Adams, S., Brew, B. J., Chung, R. & Guillemin, G. J., Nov 2010, In : PLoS ONE. 5, 11, p. 1-11 11 p., e14123.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
astrocytes
N-Methyl-D-Aspartate Receptors
Quinolinic Acid
Astrocytes
receptors

Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons

Braidy, N., Grant, R., Adams, S. & Guillemin, G. J., Jan 2010, In : FEBS Journal. 277, 2, p. 368-382 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Quinolinic Acid
Polyphenols
Hydrolyzable Tannins
Neuroprotective Agents
Apigenin
2009

Effects of kynurenine pathway metabolites on intracellular NAD + synthesis and cell death in human primary astrocytes and neurons

Braidy, N., Grant, R., Brew, B. J., Adams, S., Jayasena, T. & Guillemin, G. J., 2009, In : International Journal of Tryptophan Research. 2, 1, p. 61-69 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Kynurenine
Cell death
Metabolites
Astrocytes
NAD

Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons

Braidy, N., Grant, R., Adams, S., Brew, B. J. & Guillemin, G. J., 2009, In : Neurotoxicity Research. 16, 1, p. 77-86 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Quinolinic Acid
Cytotoxicity
Astrocytes
Neurons
NAD