Shaokoon Cheng

Associate Professor

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Personal profile


Shaokoon is the program director of the Mechanical Engineering undergraduate program at Macquarie University. His major interest is in translational research, with particular focus on the design and development of biomedical devices and equipment for disease monitoring and diagnosis. Shaokoon has received several competitive national and international research funding and they include 2 NHMRC (lead CI), 2 ARC and a grant from the Food Drug Administration (FDA, USA). Two of his inventions have been awarded patents and they are also the core technologies for a range of biomedical equipment currently being developed in his laboratory. Shaokoon has written more than 90 peer-reviewed publications and is currently leading a team of 7 PhD students and 1 postdoctoral staff to synthesize discoveries obtained from MR imaging, microfluidics, particles fluidization experiments and computational modelling. He has been invited as organizer and invited speaker for more than 10 major international conferences in his field of research. 


Research interests

We are looking for bright and enthusiastic Masters or PhD students with a strong passion to find solutions to improve the quality of lives through engineering. 

BIOMECHANICS and PART (Particles And Respiratory Technology) research group

Current projects:

1. Biomechanics of inhaled drug delivery. 
2. Novel organ-on-chip devices. 
3. Fluid-structure flow interactions in biological systems. 
4. Biomedical devices. 
5. MRI. 
6. 3D printing for biological applications. 


1.  Stereoscopic PIV system for velocity measurement including a micro-PIV system.
2.  High Speed (10KHz) and high resolution (2um) Particle Visualization and Sizing System.
3.  High-Speed Data Acquisition (1-2MHz) and Instrument Control Capabilities.
4.  Tabletop tensile machine (MTS, exceed testing system, E42.503).
5.  Micro-tensile testing machine - SEM (Scanning Electron Microscope) compatible. 
6. Advanced additive manufacturing capabilities to develop optically accessible and highly-complex geometries for any biological organs. 
7.  In house capabilities and facilities to develop organ-on-chip devices.
8.  MR Elastography system. 
9. Optical coherence tomography system (multiple channels) with extended capabilities in flow and elastography measurements. 


1. Design and development of microfluidic devices, organ-on-a-chip platform. 

2. MR Imaging - Phase Contrast MRI, MR Elastography, MR Tagging.

3. Development of optically accessible and physiologically realistic biological organs. 

4. Human and animal MR studies. Ethics applications that involved human patients and diseased animal models.

5. Computational modeling - turbulent and multi-phase flows.

6. Characterization of soft tissue rheological properties. 


My current teaching research interests are in the area of understanding students career information literacy and the development of teaching pedagogies and tools to help improve students' employability and entrepreneurial capabilities. 

Current projects:

1. Enhancing HDR students employability. 

2. Innovative learning tools to enhance product development skills.

3. Embedding effective project-based learning in an engineering curriculum. 


I have a background and a strong passion in product design and development. 

I have developed and convened the following units and the units mark with an asterisk are the units which I am currently teaching and convening. 
1. ENGG150 - Fundamentals of Mechanical and Electronics Engineering
2. MECH203 - Engineering Design 1. (*)
Computer-aided design, a framework for decision-based engineering design, machine design and analysis. (Shigley's Mechanical Engineering Design)
3. MECH204 - Mechanics of Solids. (*)
Modes and mechanics of failure, structural analysis (Hibbeler Mechanics of Materials)
4. MECH303 - Engineering Design 2
5. MECH401 - Product Design and development - Capstone unit. (*)
Product design and development process (Ulrich and Eppinger Product Design and Development)

Community engagement

Education/Academic qualification

Biomedical Engineering, PhD, The University of New South Wales

Mechanical Engineering, BEng, Honours Class 1, University of Sydney

External positions

Member, Australian Rheological Society

Member, Australian and New Zealand Society of Biomechanics

Member, Australian and New Zealand Society of Respiratory Science

Board of Directors, Cerebrospinal Fluid Hydrodynamics

Member, Society of Rheology

Fingerprint Dive into the research topics where Shaokoon Cheng is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2014 2022

Research Outputs 2005 2020

The effects of upper airway tissue motion on airflow dynamics

Zhao, Y., Raco, J., Kourmatzis, A., Diasinos, S., Chan, H-K., Yang, R. & Cheng, S., 23 Jan 2020, In : Journal of Biomechanics. 99, p. 1-6 6 p., 109506.

Research output: Contribution to journalArticleResearchpeer-review


Application of a thermosensitive in situ gel of chitosan-based nasal spray loaded with tranexamic acid for localised treatment of nasal wounds

Gholizadeh, H., Messerotti, E., Pozzoli, M., Cheng, S., Traini, D., Young, P., Kourmatzis, A., Caramella, C. & Ong, H. X., Oct 2019, In : AAPS PharmSciTech. 20, 7, 12 p., 299.

Research output: Contribution to journalArticleResearchpeer-review

Tranexamic Acid
Nasal Sprays

Development of an innovative technology to segment luminal borders of intravascular ultrasound image sequences in a fully automated manner

Moshfegh, A., Javadzadegan, A., Mohammadi, M., Ravipudi, L., Cheng, S. & Martins, R., May 2019, In : Computers in Biology and Medicine. 108, p. 111-121 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Program processors
Feasibility Studies

Does upper airway deformation affect drug deposition?

Cheng, S., Kourmatzis, A., Mekonnen, T., Gholizadeh, H., Raco, J., Chen, L., Tang, P. & Chan, H-K., 15 Dec 2019, In : International Journal of Pharmaceutics. 572, p. 1-8 8 p., 118773.

Research output: Contribution to journalArticleResearchpeer-review

Pharmaceutical Preparations
Soft Palate
Nebulizers and Vaporizers

Effect of extradural constriction on CSF flow in rat spinal cord

Berliner, J. A., Woodcock, T., Najafi, E., Hemley, S. J., Lam, M., Cheng, S., Bilston, L. E. & Stoodley, M. A., 26 Mar 2019, In : Fluids and Barriers of the CNS. 16, 1, 15 p., 7.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Subarachnoid Space
Cerebrospinal Fluid
Spinal Cord


Travel Award

Shaokoon Cheng (Recipient), Oct 2011


Activities 2010 2010

  • 1 Participating in a conference, workshop, ...

ASME 2010 International Mechanical Engineering Congress & Exposition

Shaokoon Cheng (Participant)

Activity: Participating in or organising an eventParticipating in a conference, workshop, ...