Research Output per year
Since receiving an A-grade for the Extended Essay component of the International Baccalaureate Diploma Program on the aetiology of violent crime, Sharlynn became interested in the intersection between psychology and genetics. In 2016, they were awarded a Bachelor of Science (Advanced) double majoring in Psychology and Molecular Biology and Genetics from The University of Sydney in 2016. The following year, they investigated the role of Hedgehog-related genes in neuronal development in Caenorhabditis elegans under the supervision of Dr Hannah Nicholas at The University of Sydney and was awarded a first class Honours. For the next two months, Sharlynn worked as a Research Assistant until the Nicholas lab was dissolved for personal reasons. In July 2018, Sharlynn began a Master of Research with Prof Ian Blair at the Macquarie University Centre for Motor Neuron Disease Research and under the supervision of Dr Shu Yang. During the program, Sharlynn performed in vitro assays to determine the potential pathogenicity of ALS candidate variants. Under the guidance of associate supervisor Dr Albert Lee, Sharlynn also dabbled in proteomics to investigate whether any neurodegeneration-related pathways are affected by these candidate variants.
At present, Sharlynn is a PhD candidate under the supervision of Dr Shu Yang and Prof Ian Blair, where they will continue to elucidate the pathogenicity of ALS candidate variants. They are a recipient of the competitive International Macquarie University Research Excellence Scholarship.
ALS, Cellular Biology, Master of Research, Macquarie University
2018 → 2019
Biochemistry, Bachelors of Science (Advanced) (Honours) with First Class, University of Sydney
16 Feb 2017 → Nov 2017
Molecular Biology and Psychology, Bachelors of Science (Advanced), University of Sydney
Mar 2014 → Nov 2016
Research Assistant (Nicholas), University of Sydney1 Jan 2018 → 28 Feb 2018
Creative Assistant (Denyer), University of SydneyJul 2015
Genetic and immunopathological analysis of CHCHD10 in Australian amyotrophic lateral sclerosis and frontotemporal dementia and transgenic TDP-43 miceMcCann, E. P., Fifita, J. A., Grima, N., Galper, J., Mehta, P., Freckleton, S. E., Zhang, K. Y., Henden, L., Hogan, A. L., Chan Moi Fat, S., Wu, S. S. L., Jagaraj, C. J., Berning, B. A., Williams, K. L., Twine, N. A., Bauer, D., Piguet, O., Hodges, J., Kwok, J. B. J., Halliday, G. M. & 7 others, , 1 Feb 2020, In : Journal of Neurology, Neurosurgery and Psychiatry. 91, 2, p. 162-171 10 p.
Research output: Contribution to journal › Article
A functional pipeline for the validation of novel amyotrophic lateral sclerosis (ALS) candidate genesYang, S., Wu, S., Fifita, J., McCann, E., Fat, S. C. M., Galper, J., Freckleton, S., Zhang, K. Y. & Blair, I. P., 1 Nov 2019, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 20, Supplement 1, p. 135 1 p., IVT-01.
Research output: Contribution to journal › Meeting abstract
Research output: Contribution to conference › Abstract