Projects per year
Personal profile
Biography
Sian Genoud completed her PhD in 2020 under the supervision of Prof Kay Double at The University of Sydney where she investigated the role of biometals in neurodegenerative pathways in the Parkinson's disease brain and ALS spinal cord. She then worked as a Research Officer at the Cancer Institute NSW before joining the Dementia Research Centre at Macquarie University as a Postdoctoral Research Fellow with Prof Thomas Fath in February 2021.
Education/Academic qualification
Medicine and Health, PhD, The role of biometals in the neuropathology of Parkinson's disease, Brain and Mind Centre, The University of Sydney
Mar 2016 → Feb 2020
Award Date: 3 Aug 2020
Pharmacology and Neuroscience, Bachelor of Science (Hons I), Superoxide dismutase 1 and cuproprotein pathology in Parkinson's disease, Brain and Mind Centre, The University of Sydney
Feb 2011 → Nov 2015
Award Date: 30 Nov 2015
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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DARF: Investigating mechanisms of tau uptake and release in glia
Genoud, S. (Primary Chief Investigator), Fath, T. (Associate Investigator), Van Eersel, J. (Associate Investigator) & Ittner, L. (Associate Investigator)
8/04/24 → 8/04/26
Project: Research
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Unravelling the molecular mechanism of tau spread in Alzheimer's disease
Genoud, S. (Investigator) & Fath, T. (Primary Chief Investigator)
Project: Research
Research Outputs
- 9 Article
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Engineered cyclotide blocks neuronal excitotoxicity
Ariawan, D., van der Hoven, J., Morey, N., Pushpitha, K., Genoud, S., Stefen, H., Veltman, S., Przybyla, M., Deng, Y., Fath, T., Tietz, O., van Eersel, J. & Ittner, L. M., 13 Mar 2025, In: Journal of Medicinal Chemistry. 68, 5, p. 5211-5221 11 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Knock-out of Tpm4.2/actin filaments alters neuronal signaling, neurite outgrowth, and behavioral phenotypes in mice
Genoud, S., Chaichim, C., Porto, R. R., Tomanic, T., Stefen, H., Paric, E., Sarkar, S., Yoo, D., Gao, W., Hardeman, E. C., Gunning, P. W., Karl, T., Power, J. & Fath, T., Dec 2025, In: Molecular Neurobiology. 62, 12, p. 16316-16341 26 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Parkinson-like wild-type superoxide dismutase 1 pathology induces nigral dopamine neuron degeneration in a novel murine model
Abdeen, A. H., Trist, B. G., Nikseresht, S., Harwood, R., Roudeau, S., Rowlands, B. D., Kreilaus, F., Cottam, V., Mor, D., Richardson, M., Siciliano, J., Forkgen, J., Schaffer, G., Genoud, S., Li, A. A., Proschogo, N., Antonio, B., Falkenberg, G., Brueckner, D. & Kysenius, K. & 10 others, , 5 Mar 2025, In: Acta Neuropathologica. 149, 1, p. 1-28 28 p., 22.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus) -
Design of peptide therapeutics as protein-protein interaction inhibitors to treat neurodegenerative diseases
Ariawan, D., Pushpitha, K. P. M., El-Omar, A., van der Hoven, J., Genoud, S., Stefen, H., Fath, T., van Eersel, J., Ittner, L. M. & Tietz, O., 30 Oct 2024, In: RSC Advances. 14, 47, p. 34637-34642 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)71 Downloads (Pure) -
Altered SOD1 maturation and post-translational modification in amyotrophic lateral sclerosis spinal cord
Trist, B. G., Genoud, S., Roudeau, S., Rookyard, A., Abdeen, A., Cottam, V., Hare, D. J., White, M., Altvater, J., Fifita, J. A., Hogan, A., Grima, N., Blair, I. P., Kysenius, K., Crouch, P. J., Carmona, A., Rufin, Y., Claverol, S., Van Malderen, S. & Falkenberg, G. & 10 others, , 14 Sept 2022, In: Brain. 145, 9, p. 3108-3130 23 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile50 Citations (Scopus)93 Downloads (Pure)
Activities
- 1 Membership of committee
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Faculty of Medicine, Health and Human Sciences (Organisational unit)
Sarkies, M. (Member), Bright, F. (Member), De Luca, K. (Member), Ilhan, E. (Member), Nguyen, A. (Member), Austin, E. (Member), Carrigan, A. (Member), Seaman, K. (Member), Bladen, C. (Member), van Hummel, A. (Member), Baker, J. (Member), Ross, R. (Member), Genoud, S. (Member), Don, E. (Chair), Chitranshi, N. (Member), Hardie, R.-A. (Chair), Ronto, R. (Member), Sicouri, G. (Member), Williams, K. (Member), Owais, S. S. (Member), Guller, A. (Member), Newport, R. (Member), Junqueira Santiago, M. (Member), Gilchrist, P. (Member), Chen, J. (Member), Oar, E. (Member), Hogan, A. (Member), Wills, J. (Member), Yin, K. (Member), Hulst, G. (Member), Brown, B. (Member), Koring, L. (Member), Whillier, S. (Member), Gandy, M. (Member), Johnco, C. (Member), McLellan, L. (Member) & Swain, M. (Member)
2020 → …Activity: Membership › Membership of committee