Research output per year
Research output per year
Personal profile
Biography
Dr Sina Shadfar is an Early Career Postdoctoral Research Fellow in the Cellular Neurobiology Team within the multidisciplinary Centre for Motor Neuron Disease (MND) Research at Macquarie University. Dr Shadfar received his master’s degree in neuropharmacology from the college of Pharmacy, Yeungnam University in South Korea, where he studied the role of neurotrophic factors in Parkinson’s and Alzheimer’s disease. During 2014 ‐ 2017, he worked as a research assistant and lab manager in the College of Pharmacy, Yeungnam University.
During his PhD, Dr Shadfar has identified novel proteins as new therapeutic targets for MND in both cells and in vivo models (zebrafish, rodents, and C. elegans). In 2018, he was awarded Federation of Europian Neuroscience Societies and International Brain Organization's (FENS-IBRO) young investigators training grant to join to the Leibniz Institute for Molecular Pharmacology (FMP) in Berlin, Germany, where he trained to use Caenorhabditis elegans (C. elegans) as a model to study ALS, under the supervision of Prof. Dr. Janine Kirstein.
Research interests
Cellular and Molecular Neurobiology; Neurodegenerative Disease; Amyotrophic Lateral sclerosis; Motor Neuron Disease
Teaching
- MEDI2900; Introduction to Medical Research, Macquarie Medical School, Macquarie University, Australia
- MEDI3301; Clinical Neurosciences, Department of Clinical Medicine, Macquarie University, Australia
-MEDI304; Advanced Clinical Science, Department of Biomedical Sciences, Macquarie University, Australia
- CBMS 201/ CBMS 602; Biochemistry and Cell Biology, Department of Chemistry and Biomolecular Sciences, Macquarie University, Australia
- Advanced Pharmacology, College of Pharmacy, Yeungnam University, South Korea, 2014-2017
Research student supervision
Macquarie University, Australia
Fabiha Farzana, MRes Student, (Associate supervisor)
Tia Laquinto, Bachelor of Clinical Sciences Student (Academic mentor)
Jaylen Collett, Bachelor of Clinical Sciences Student (Academic mentor)
Community engagement
- Member of Macquarie University MND centre social committee team; 2021- present
- HDR students representative at Macquarie University MND centre executive committee; 2019- 2021
- Member of Macquarie University MND centre social media team; 2020- present
- Atkin's lab representative at the Faculty of Medicine and Health Sciences Lab users meeting; 2018- present
Education/Academic qualification
Neurobiology, PhD, Macquarie University
2017 → 2021
Award Date: 8 Apr 2021
Neuropharmacology, Master's degree, Yeungnam University
30 Sep 2013 → 22 Feb 2016
Award Date: 22 Feb 2016
External positions
Research/Teaching assistant, Yeungnam University
2014 → 2017
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Research Outputs
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Methanolic extract of Boswellia serrata gum protects the nigral dopaminergic neurons from rotenone-induced neurotoxicity
Shadfar, S., Khanal, S., Bohara, G., Kim, G., Sadigh-Eteghad, S., Ghavami, S., Choi, H. & Choi, D-Y., 8 Jul 2022, (E-pub ahead of print) In: Molecular Neurobiology. 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The complex mechanisms by which neurons die following DNA damage in neurodegenerative diseases
Shadfar, S., Brocardo, M. & Atkin, J. D., 24 Feb 2022, In: International Journal of Molecular Sciences. 23, 5, p. 1-39 39 p., 2484.Research output: Contribution to journal › Review article › peer-review
Open AccessFile1 Citation (Scopus)12 Downloads (Pure) -
Protein disulphide isomerase (PDI) is protective against amyotrophic lateral sclerosis (ALS)-related mutant Fused in Sarcoma (FUS) in in vitro models
Parakh, S., Perri, E. R., Vidal, M., Sultana, J., Shadfar, S., Mehta, P., Konopka, A., Thomas, C. J., Spencer, D. M. & Atkin, J. D., 2 Sep 2021, In: Scientific Reports. 11, 1, p. 1-14 14 p., 17557.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Downloads (Pure) -
Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations
Konopka, A., Whelan, D. R., Jamali, M. S., Perri, E., Shahheydari, H., Toth, R. P., Parakh, S., Robinson, T., Cheong, A., Mehta, P., Vidal, M., Ragagnin, A. M. G., Khizhnyak, I., Jagaraj, C. J., Galper, J., Grima, N., Deva, A., Shadfar, S., Nicholson, G. A., Yang, S. & 6 others, , 9 Sep 2020, In: Molecular Neurodegeneration. 15, 1, p. 1-28 28 p., 51.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)21 Downloads (Pure) -
The redox activity of protein disulfide isomerase inhibits ALS phenotypes in cellular and zebrafish models
Parakh, S., Shadfar, S., Perri, E. R., Ragagnin, A. M. G., Piattoni, C. V., Fogolín, M. B., Yuan, K. C., Shahheydari, H., Don, E. K., Thomas, C. J., Hong, Y., Comini, M. A., Laird, A. S., Spencer, D. M. & Atkin, J. D., 22 May 2020, In: iScience. 23, 5, p. 1-27 27 p., 101097.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)11 Downloads (Pure)
Prizes
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Department of Biomedical Sciences Early- and Mid-Career Research grant
Shadfar, Sina (Recipient), 2021
Prize
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Macquarie University Postgraduate Research Fund (PGRF)
Shadfar, Sina (Recipient), 2018
Prize: Other distinction
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Activities
- 1 Organising a conference, workshop or event series
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Macquarie Neurodegeneration Meeting
Sina Shadfar (Participant)
Feb 2021 → Sep 2021Activity: Participating in or organising an event › Organising a conference, workshop or event series