Projects per year
Personal profile
Biography
Dr. Sina Shadfar is an early career research fellow and lecturer at Macquarie University’s Motor Neuron Disease (MND) Research Centre, where he is at the forefront of groundbreaking research into neurodegenerative diseases.
His journey began with a master’s degree in neuropharmacology from Yeungnam University in South Korea, where he explored how brain-protecting proteins could help fight Parkinson’s and Alzheimer’s disease. In 2017, his passion for neuroscience brought him to Australia, where he earned his Ph.D. in Neurobiology at Macquarie Medical School. His research uncovered new proteins that could be targeted for potential MND treatments, using advanced models like cell cultures, zebrafish, rodents, and even microscopic worms (C. elegans).
Dr. Shadfar has published 29 research articles in top-tier scientific journals,including Brain, Aging Cell, Translational Neurodegeneration and Molecular Neurodegeneration, shedding light on ways to combat neurodegeneration. His current focus is tackling aging as a key driver of MND. He has secured 6 major research grants and a fellowship to advance this mission. Notably, his latest project, backed by FightMND, is Australia’s first-ever mRNA therapy targeting aging in MND, a pioneering step toward new treatments.
His dedication has been recognized with 13 prestigious scholarships, awards, and international research fellowships. In 2018, he was selected for the prestigious FENS-IBRO Young Investigators Training Fellowship, allowing him to train at FMP Berlin, Germany.
Research interests
Aging Neuroscience; Gene therapy: Neurodegenerative Disease; Motor Neuron Disease
Teaching
- MEDI 2200; Human Cell and Molecular Biology, Macquarie University, Australia
- MEDI2302; Cellular and Molecular Neuroscince, Macquarie University, Australia
- MEDI2300; Neuroanatomy, Macquarie Medical School, Macquarie University, Australia
- MEDI2900; Introduction to Medical Research, Macquarie Medical School, Macquarie University, Australia
- MEDI3301; Clinical Neurosciences, Department of Clinical Medicine, Macquarie University, Australia
-MEDI304; Advanced Clinical Science, Department of Biomedical Sciences, Macquarie University, Australia
- CBMS 201/ CBMS 602; Biochemistry and Cell Biology, Department of Chemistry and Biomolecular Sciences, Macquarie University, Australia
- Advanced Pharmacology, College of Pharmacy, Yeungnam University, South Korea, 2014-2017
Research student supervision
Macquarie University, Australia
Emmaline Frogley, MRes Student, (Associate supervisor); 2025-Date
Fabiha Farzana, PhD Candidate, (Associate supervisor); 2023- Date
Matin Ramezani, PhD Candidate, (Associate supervisor); 2022-2026
Fabiha Farzana, MRes Student, (Associate supervisor);2021-2022
Tia Laquinto, Bachelor of Clinical Sciences Student (Academic mentor); 2020
Jaylen Collett, Bachelor of Clinical Sciences Student (Academic mentor); 2017
Teaching and Leadership
- NeuroAlliance Advisory Board, Australian Neuroscince Society, 2026
- Chair, Macquarie University ECR showcase committee 2026
- Neuroscience panel chair, Young scientist program 2025 (YSP 2025/ FAOMB), May 2025 Busan, South Korea
- Chair, ECR Enabling Scheme Grant Assessment Panel, Macquarie University (2025)
- Head of Selection Committee, Best Annual Publication Award, Centre for MND Research, Macquarie Medical School, 2022- date
-Macquarie Medical School ECR Representative, at Macquarie University ECR community (Dec 2024–present)
-President, EnCourage ECR Symposium, Faculty of Medicine and Health Sciences, Macquarie University (Sept 2023)
- Member of Organizing Committee and panel Chair, Macquarie Neurodegeneration Meeting (MNM), Macquarie University, September 2021, 2022, 2023
- HDR students representative at Macquarie University MND centre executive committee; 2019- 2021
Education/Academic qualification
Neurobiology, PhD, Macquarie University
2017 → 2021
Award Date: 8 Apr 2021
Neuropharmacology, Master's degree, Neuroprotective effects of antidepressants via upregulation of neurotrophic factors in the MPTP model of Parkinson’s disease, Yeungnam University
30 Sept 2013 → 22 Feb 2016
Award Date: 22 Feb 2016
External positions
Research/Teaching assistant, Yeungnam University
2014 → 2017
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
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FightMND 24: Novel Gene Therapy Approaches for Targeting Aging in MND
Shadfar, S. (Primary Chief Investigator), Atkin, J. (Chief Investigator), Dhungel, B. (Chief Investigator) & Thordarson, P. (Partner Investigator)
3/03/25 → 2/03/27
Project: Research
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EES 2023: Shadfar_Sina_EES 2023
Shadfar, S. (Primary Chief Investigator)
30/03/23 → 31/12/23
Project: Research
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Cellular Senescence as a Novel Mechanism of Pathogenesis in ALS
Atkin, J. (Primary Chief Investigator), Guillemin, G. (Chief Investigator), Shadfar, S. (Chief Investigator) & Parakh, S. (Chief Investigator)
30/06/22 → 30/06/23
Project: Research
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EES 2022: Shadfar_Sina_EES2022
Shadfar, S. (Primary Chief Investigator)
8/05/22 → 31/12/22
Project: Research
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MQCRF_R1_2021: Defining novel links between DNA repair, aging and redox regulation in motor neuron disease (MND).
Shadfar, S. (Primary Chief Investigator) & Atkin, J. (Supervisor)
15/12/21 → 14/12/22
Project: Research
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Cofilin hyperphosphorylation triggers TDP-43 pathology in sporadic amyotrophic lateral sclerosis
Jagaraj, C. J., Saravanabavan, S., Parakh, S., Jayakumar, M., Assar Kashani, S., Shadfar, S., Mehta, P., Gautam, S., Farzana, F., Suchowerska, A. K., Yap, K., Vidal, M., Ragagnin, A. M. G., Jamali, M. S., Yang, S., Fath, T., Craik, D. & Atkin, J. D., 10 Mar 2026, (Accepted/In press) In: Brain.Research output: Contribution to journal › Article › peer-review
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The role of the Golgi apparatus in neurodegeneration
Shadfar, S., Assar Kashani, S., Gautam, S., Takalloo, Z., Farzana, F., Parakh, S. & Atkin, J. D., Feb 2026, The Golgi Network: Volume II: Golgi functions. Nakano, A. & Saraste, J. (eds.). Switzerland: Springer, Springer Nature, p. 413-440 28 p. (Subcellular Biochemistry; vol. 111).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
1 Link opens in a new tab Citation (Scopus) -
Pathological forms of TDP-43 in amyotrophic lateral sclerosis (ALS) promote aberrant telomere elongation
Konopka, A., Jamali, M. S., Fowler, M., Mehta, P., Parakh, S., Takalloo, Z., Farzana, F., Mumtaz, N., Hunter, J., Shadfar, S., Rogers, M.-L. & Atkin, J. D., Oct 2025, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1871, 7, p. 1-13 13 p., 167906.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Link opens in a new tab Citation (Scopus)54 Downloads (Pure) -
The redox activity of protein disulphide isomerase functions in non-homologous end-joining repair to prevent DNA damage
Shadfar, S., Farzana, F., Saravanabavan, S., Rozario, A. M., Vidal, M., Jagaraj, C. J., Parakh, S., Paric, E., Yuan, K. C., Brocardo, M., Whelan, D. R., Laird, A. S. & Atkin, J. D., Jul 2025, In: Aging Cell. 24, 7, p. 1-23 23 p., e70079.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Link opens in a new tab Citations (Scopus)29 Downloads (Pure) -
Amyloid-beta and tau protein beyond Alzheimer's disease
Abyadeh, M., Gupta, V., Paulo, J. A., Mahmoudabad, A. G., Shadfar, S., Mirshahvaladi, S., Gupta, V., Nguyen, C. T. O., Finkelstein, D. I., You, Y., Haynes, P. A., Salekdeh, G. H., Graham, S. L. & Mirzaei, M., 1 Jun 2024, In: Neural Regeneration Research. 19, 6, p. 1262-1276 15 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile107 Link opens in a new tab Citations (Scopus)377 Downloads (Pure)
Prizes
Activities
- 2 Organising a conference, workshop or event series
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2023 EnCouRage Symposium
Shadfar, S. (Participant)
1 Feb 2023 → 1 Sept 2023Activity: Participating in or organising an event › Organising a conference, workshop or event series
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Macquarie Neurodegeneration Meeting
Shadfar, S. (Participant)
Feb 2021 → Sept 2021Activity: Participating in or organising an event › Organising a conference, workshop or event series
Press/Media
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New DNA discovery to treat Dementia and more
5/07/25
1 item of Media coverage
Press/Media: Expert Comment
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DNA 'glue' could help prevent and treat diseases triggered by ageing
17/06/25
1 Media contribution
Press/Media: Expert Comment