Projects per year
Personal profile
Biography
I am early career researcher working at the MND Centre in Macquarie University. I have a strong focus working on MND disease and to identify and characterize the molecular origins of MND/ALS so to develop future therapeutic targets.
Education/Academic qualification
Neuroscience, PhD, Role of Protein Disulphide Isomerase and its Family Members in Amyotrophic Lateral Sclerosis, Macquarie University
Award Date: 16 Feb 2016
Biotechnology and Bioinfromatics, Masters, La Trobe University
Award Date: 15 Nov 2012
Biotechnology, Bachelor's, Bangalore University
Award Date: 22 Aug 2009
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Collaborations and top research areas from the last five years
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MND 24: Investigating the role of GABAA agonists as novel therapeutic against TDP-43 pathology.
Parakh, S., Blizzard, C. A. & Atkin, J.
1/06/25 → 31/05/26
Project: Research
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MNDRA Innovator: Nucleoredoxin (NRX), a novel gene therapy target against TDP43 multifaceted pathogenic mechanisms.
Parakh, S., Gupta, V., Chitranshi, N., McCann, E. & Atkin, J.
30/06/23 → 29/06/24
Project: Research
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Macquarie University Centre for Motor Neuron Disease Research
Blair, I. (Primary Chief Investigator), Rowe, D. (Chief Investigator), Guillemin, G. (Chief Investigator), Chung, R. (Chief Investigator), Atkin, J. (Chief Investigator), Cole, N. (Chief Investigator), Laird, A. (Associate Investigator), Lim, E. (Associate Investigator), Williams, K. (Associate Investigator), Yang, S. (Associate Investigator), Morsch, M. (Associate Investigator), Lee, A. (Associate Investigator), Shi, B. (Associate Investigator), Walker, A. K. (Associate Investigator), Lovejoy, D. (Associate Investigator), Furlong, S. (Other), Adams, L. (Other), Syal, D. (Animal Technician), Bazzi, R. (Animal Technician), Svahn, A. (Associate Investigator), Parakh, S. (Associate Investigator), Shahheydari, H. (Associate Investigator), Konopka, A. (Associate Investigator), Ragagnin, A. (Associate Investigator), Mehta, P. (Associate Investigator), Wright, A. (Associate Investigator), Bourbon, L. (Associate Investigator), Sabaretnam, M. (Associate Investigator), Don, E. (Associate Investigator), Hortle, E. (Associate Investigator), De Luca, A. (Research Assistant), Zhang, K. (Research Assistant), Tarr, I. (Research Assistant), Galper, J. (Research Assistant), Varney, B. (Research Assistant), Chow, S. (Research Assistant) & Formella, I. (Research Assistant)
1/01/17 → 31/12/19
Project: Research
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Establishing a centralised biobank for biomedical research
Rizos, H. (Primary Chief Investigator), Kefford, R. (Chief Investigator), Atkin, J. (Chief Investigator), Blair, I. (Chief Investigator), Guillemin, G. (Chief Investigator), Rowe, D. (Chief Investigator), Parakh, S. (Student), Sultana, J. (Student), Fifita, J. (Student) & Tan, V. (Student)
1/01/15 → 31/12/15
Project: Research
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Pathological forms of TDP-43 in amyotrophic lateral sclerosis (ALS) promote aberrant telomere elongation
Konopka, A., Jamali, M. S., Fowler, M., Mehta, P., Parakh, S., Takalloo, Z., Farzana, F., Mumtaz, N., Hunter, J., Shadfar, S., Rogers, M.-L. & Atkin, J. D., Oct 2025, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1871, 7, p. 1-13 13 p., 167906.Research output: Contribution to journal › Article › peer-review
Open AccessFile48 Downloads (Pure) -
The redox activity of protein disulphide isomerase functions in non-homologous end-joining repair to prevent DNA damage
Shadfar, S., Farzana, F., Saravanabavan, S., Rozario, A. M., Vidal, M., Jagaraj, C. J., Parakh, S., Paric, E., Yuan, K. C., Brocardo, M., Whelan, D. R., Laird, A. S. & Atkin, J. D., Jul 2025, In: Aging Cell. 24, 7, p. 1-23 23 p., e70079.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Downloads (Pure) -
C9orf72-associated dipeptide repeat expansions perturb ER-golgi vesicular trafficking, inducing golgi fragmentation and ER stress, in ALS/FTD
Sultana, J., Ragagnin, A. M. G., Parakh, S., Saravanabavan, S., Soo, K. Y., Vidal, M., Jagaraj, C. J., Ding, K., Wu, S., Shadfar, S., Don, E. K., Deva, A., Nicholson, G., Rowe, D. B., Blair, I., Yang, S. & Atkin, J. D., Dec 2024, In: Molecular Neurobiology. 61, 12, p. 10318-10338 21 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)28 Downloads (Pure) -
Protein disulfide isomerase endoplasmic reticulum protein 57 (ERp57) is protective against ALS-associated mutant TDP-43 in neuronal cells
Parakh, S., Perri, E. R., Vidal, M., Takalloo, Z., Jagaraj, C. J., Mehta, P., Yang, S., Thomas, C. J., Blair, I. P., Hong, Y. & Atkin, J. D., 11 Jun 2024, In: NeuroMolecular Medicine. 26, 1, p. 1-15 15 p., 23.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)39 Downloads (Pure) -
ALS/FTD-associated mutation in cyclin F inhibits ER-Golgi trafficking, inducing ER stress, ERAD and Golgi fragmentation
Ragagnin, A. M. G., Sundaramoorthy, V., Farzana, F., Gautam, S., Saravanabavan, S., Takalloo, Z., Mehta, P., Do-Ha, D., Parakh, S., Shadfar, S., Hunter, J., Vidal, M., Jagaraj, C. J., Brocardo, M., Konopka, A., Yang, S., Rayner, S. L., Williams, K. L., Blair, I. P. & Chung, R. S. & 3 others, , 22 Nov 2023, In: Scientific Reports. 13, 1, p. 1-20 20 p., 20467.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)88 Downloads (Pure)