Sonam Parakh

Dr

  • 335 Citations
  • 7 h-Index
20132019
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Research Outputs 2013 2019

  • 335 Citations
  • 7 h-Index
  • 8 Article
  • 5 Review article
2019

Amyotrophic lateral sclerosis-linked UBQLN2 mutants inhibit endoplasmic reticulum to Golgi transport, leading to Golgi fragmentation and ER stress

Halloran, M., Ragagnin, A. M. G., Vidal, M., Parakh, S., Yang, S., Heng, B., Grima, N., Shahheydari, H., Soo, K-Y., Blair, I., Guillemin, G. J., Sundaramoorthy, V. & Atkin, J. D., 4 Dec 2019, In : Cellular and Molecular Life Sciences. 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Endoplasmic Reticulum Stress
Amyotrophic Lateral Sclerosis
Endoplasmic Reticulum
Protein Transport
Endoplasmic Reticulum-Associated Degradation

Protein disulphide isomerase is associated with mutant SOD1 in canine degenerative myelopathy

Chang, R. C., Parakh, S., Coates, J. R., Long, S. & Atkin, J. D., 2 Jan 2019, In : NeuroReport. 30, 1, p. 8-13 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein Disulfide-Isomerases
Spinal Cord Diseases
Canidae
Amyotrophic Lateral Sclerosis
Endoplasmic Reticulum Stress
2018

ERp57 is protective against mutant SOD1-induced cellular pathology in amyotrophic lateral sclerosis

Parakh, S., Jagaraj, C. J., Vidal, M., Ragagnin, A. M. G., Perri, E. R., Konopka, A., Toth, R. P., Galper, J., Blair, I. P., Thomas, C. J., Walker, A. K., Yang, S., Spencer, D. M. & Atkin, J. D., 15 Apr 2018, In : Human molecular genetics. 27, 8, p. 1311-1331 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyotrophic Lateral Sclerosis
Endoplasmic Reticulum Stress
Pathology
Apoptosis
DNA-Binding Proteins

Rab-dependent cellular trafficking and amyotrophic lateral sclerosis

Parakh, S., Perri, E. R., Jagaraj, C. J., Ragagnin, A. M. G. & Atkin, J. D., 2 Nov 2018, In : Critical Reviews in Biochemistry and Molecular Biology. 53, 6, p. 623-651 29 p.

Research output: Contribution to journalReview articleResearchpeer-review

rab GTP-Binding Proteins
Amyotrophic Lateral Sclerosis
Neurons
Defects
Intracellular Membranes
2017

Protein Disulphide Isomerases: emerging roles of PDI and ERp57 in the nervous system and as therapeutic targets for ALS

Perri, E., Parakh, S. & Atkin, J., 2 Jan 2017, In : Expert Opinion on Therapeutic Targets. 21, 1, p. 37-49 13 p.

Research output: Contribution to journalReview articleResearchpeer-review

Protein Disulfide-Isomerases
Amyotrophic Lateral Sclerosis
Neurology
Endoplasmic Reticulum
Nervous System
2016

Efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis

Browne, E. C., Parakh, S., Duncan, L. F., Langford, S. J., Atkin, J. D. & Abbott, B. M., 1 Apr 2016, In : Bioorganic and Medicinal Chemistry. 24, 7, p. 1520-1527 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Peptide Nucleic Acids
Amyotrophic Lateral Sclerosis
Pathology
Superoxide Dismutase
Nucleic acid sequences

Protein folding alterations in amyotrophic lateral sclerosis

Parakh, S. & Atkin, J. D., 1 Oct 2016, In : Brain Research. 1648, p. 633-649 17 p.

Research output: Contribution to journalReview articleResearchpeer-review

Protein Folding
Amyotrophic Lateral Sclerosis
Proteins
Neurodegenerative Diseases
Protein Disulfide-Isomerases
2015

Novel roles for protein disulphide isomerase in disease states: a double edged sword?

Parakh, S. & Atkin, J. D., 2015, In : Frontiers in cell and developmental biology. 3, p. 1-11 11 p., 30.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Protein Disulfide-Isomerases
Post Translational Protein Processing
Endoplasmic Reticulum
Oxidation-Reduction

Rab1-dependent ER-Golgi transport dysfunction is a common pathogenic mechanism in SOD1, TDP-43 and FUS-associated ALS

Soo, K. Y., Halloran, M., Sundaramoorthy, V., Parakh, S., Toth, R. P., Southam, K. A., McLean, C. A., Lock, P., King, A., Farg, M. A. & Atkin, J. D., 1 Nov 2015, In : Acta Neuropathologica. 130, 5, p. 679-697 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyotrophic Lateral Sclerosis
Endoplasmic Reticulum
Protein Transport
Motor Neurons
Endoplasmic Reticulum Stress

The unfolded protein response and the role of Protein Disulfide Isomerase in neurodegeneration

Perri, E. R., Thomas, C. J., Parakh, S., Spencer, D. M. & Atkin, J. D., 2015, In : Frontiers in cell and developmental biology. 3, p. 1-17 17 p., 80.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Protein Disulfide-Isomerases
Unfolded Protein Response
Endoplasmic Reticulum Stress
Endoplasmic Reticulum
Neurodegenerative Diseases
2013

ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation

Walker, A. K., Soo, K. Y., Sundaramoorthy, V., Parakh, S., Ma, Y., Farg, M. A., Wallace, R. H., Crouch, P. J., Turner, B. J., Horne, M. K. & Atkin, J. D., 29 Nov 2013, In : PLoS ONE. 8, 11, p. 1-12 12 p., e81170.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Endoplasmic Reticulum Stress
DNA-binding proteins
Amyotrophic Lateral Sclerosis
DNA-Binding Proteins
endoplasmic reticulum

Redox regulation in amyotrophic lateral sclerosis

Parakh, S., Spencer, D. M., Halloran, M. A., Soo, K. Y. & Atkin, J. D., 2013, In : Oxidative Medicine and Cellular Longevity. 2013, p. 1-12 12 p., 408681.

Research output: Contribution to journalReview articleResearchpeer-review

Open Access
File
Amyotrophic Lateral Sclerosis
Oxidation-Reduction
Protein Disulfide-Isomerases
Motor Neurons
Oxidation

The role of S-nitrosylation and S-glutathionylation of protein disulphide isomerase in protein misfolding and neurodegeneration

Halloran, M., Parakh, S. & Atkin, J. D., 2013, In : International Journal of Cell Biology. 2013, p. 1-15 15 p., 797914.

Research output: Contribution to journalReview articleResearchpeer-review

Open Access
File
Protein Disulfide-Isomerases
Neurodegenerative Diseases
Proteins
Endoplasmic Reticulum Stress
Molecular Chaperones