Projects per year
Personal profile
Biography
Stephanie is a post-doctoral research fellow and a recipient of a FightMND Early Career Research Fellowship (2024-2028) which will enable her to work in the labs of Aaron Gitler (Stanford Univeristy), Eleanor Drummond (Univeristy of Sydney) and Albert Lee (Macquarie University).
Previously, she has been a recipient of the Macquarie University Research Fellow (MQRF, 2021-2024) and completed this fellowship at the Centre for MND Research. She was awarded her PhD from Macquarie University in 2020, along with the Vice Chancellor’s Commendation for Academic Excellence and Ramy Razavian Dean Award for Academic Excellence. She was also the winner of the 2019 research Excellence Awards (STEMM category).
Her research work has been focused on understanding how mutations in cyclin F are causing Motor Neuron Disease (MND). Accordingly, her expertise has been developed in understanding mechanisms of neurodegeneration using mass spectrometry and biochemical assays. Whilst answering this question, she travelled to Copenhagen to work with cyclin F expert, Claus Sørensen. Here, she learned assays focused on direct protein-protein interactions which could be brought back to Australia. Through this work, Stephanie has identified a novel substrate of cyclin F which links cyclin F mutations to MND. Notably, this new interaction can be utilised to enhance the clearance of a protein that is known to form pathological aggregates in MND cases. Accordingly, this aspect of the work has led to the filing of multiple patents.
Her current work is dedicated to continue developing methods to prevent the formation of toxic disease-causing aggregates that are closely linked to the progression of Motor Neurone Disease.
Education/Academic qualification
Bachelor of Science (1st class honours), Macquarie University
PhD, Macquarie University
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Collaborations and top research areas from the last five years
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Development of a TDP43-targeting gene therapy for ALS
Chung, R., Lisowski, L., Walker, A. K., Rogers, M., Lee, A., Morsch, M. & Rayner, S.
1/10/20 → 30/09/23
Project: Research
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Clearance of TDP-43 by PROteolysis TArgeting Chimera (PROTAC) dual targeting to treat amyotrophic lateral sclerosis (ALS)
Lee, A., Rayner, S., Martin, A., van Hummel, A., Morsch, M., Shi, B., Ke, Y., Ittner, L. & Chung, R.
4/05/20 → 3/05/21
Project: Research
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Refinement of CCNF gene therapy for MND
Rayner, S., Lee, A. & Chung, R.
1/08/19 → 30/06/20
Project: Research
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Revealing the role of protein clearance pathways in sporadic ALS
Chung, R., Lee, A., Rayner, S. & Yang, S.
1/05/19 → 30/04/20
Project: Research
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Pre-clinical evaluation of novel therapies for clearance of TDP-43 in amyotrophic lateral sclerosis
Chung, R., Walker, A. K., Ittner, L., Lee, A. & Rayner, S.
1/01/19 → 31/12/19
Project: Research
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ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis
Farrawell, N. E., Bax, M., McAlary, L., Mckenna, J., Maksour, S., Do-Ha, D., Rayner, S. L., Blair, I. P., Chung, R. S., Yerbury, J. J., Ooi, L. & Saunders, D. N., 15 Jul 2023, In: Human Molecular Genetics. 32, 14, p. 2386-2398 13 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Identification of phosphorylated Tau protein interactors in progressive supranuclear palsy (PSP) reveals networks involved in protein degradation, stress response, cytoskeletal dynamics, metabolic processes, and neurotransmission
Radford, R. A. W., Rayner, S. L., Szwaja, P., Morsch, M., Cheng, F., Zhu, T., Widagdo, J., Anggono, V., Pountney, D. L., Chung, R. & Lee, A., May 2023, In: Journal of Neurochemistry. 165, 4, p. 563-586 24 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Downloads (Pure) -
Inter-regional proteomic profiling of the human brain using an optimized protein extraction method from formalin-fixed tissue to identify signaling pathways
Davidson, J. M., Rayner, S. L., Liu, S., Cheng, F., Ieva, A. D., Chung, R. S. & Lee, A., 21 Feb 2023, In: International Journal of Molecular Sciences. 24, 5, p. 1-18 18 p., 4283.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Downloads (Pure) -
The E3 ubiquitin ligase SCF cyclin F promotes sequestosome-1/p62 insolubility and foci formation and is dysregulated in ALS and FTD pathogenesis
Davidson, J. M., Wu, S. S. L., Rayner, S. L., Cheng, F., Duncan, K., Russo, C., Newbery, M., Ding, K., Scherer, N. M., Balez, R., García-Redondo, A., Rábano, A., Rosa-Fernandes, L., Ooi, L., Williams, K. L., Morsch, M., Blair, I. P., Di Ieva, A., Yang, S., Chung, R. S., & 1 others , Sept 2023, In: Molecular Neurobiology. 60, 9, p. 5034-5054 21 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
Cyclin F, Neurodegeneration, and the Pathogenesis of ALS/FTD
Rayner, S. L., Hogan, A., Davidson, J. M., Cheng, F., Luu, L., Morsch, M., Blair, I., Chung, R. & Lee, A., 5 Sept 2022, (E-pub ahead of print) In: The Neuroscientist. 15 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus)