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Biography
Stephanie is a post-doctoral research fellow and a recipient of a FightMND Early Career Research Fellowship (2024-2028) which will enable her to work in the labs of Aaron Gitler (Stanford Univeristy), Eleanor Drummond (Univeristy of Sydney) and Albert Lee (Macquarie University).
Previously, she has been a recipient of the Macquarie University Research Fellow (MQRF, 2021-2024) and completed this fellowship at the Centre for MND Research. She was awarded her PhD from Macquarie University in 2020, along with the Vice Chancellor’s Commendation for Academic Excellence and Ramy Razavian Dean Award for Academic Excellence. She was also the winner of the 2019 research Excellence Awards (STEMM category).
Her research work has been focused on understanding how mutations in cyclin F are causing Motor Neuron Disease (MND). Accordingly, her expertise has been developed in understanding mechanisms of neurodegeneration using mass spectrometry and biochemical assays. Whilst answering this question, she travelled to Copenhagen to work with cyclin F expert, Claus Sørensen. Here, she learned assays focused on direct protein-protein interactions which could be brought back to Australia. Through this work, Stephanie has identified a novel substrate of cyclin F which links cyclin F mutations to MND. Notably, this new interaction can be utilised to enhance the clearance of a protein that is known to form pathological aggregates in MND cases. Accordingly, this aspect of the work has led to the filing of multiple patents.
Her current work is dedicated to continue developing methods to prevent the formation of toxic disease-causing aggregates that are closely linked to the progression of Motor Neurone Disease.
Education/Academic qualification
Bachelor of Science (1st class honours), Macquarie University
PhD, Macquarie University
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Collaborations and top research areas from the last five years
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IDEAS 23: TDP-43 nuclear depletion in MND - potential driver of neurodegeneration and therapeutic target
Hogan, A., Maurel, C., Rayner, S., Morsch, M., Williams, K., Walker, A. K. & Lisowski, L.
1/07/24 → 30/06/27
Project: Research
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FightMND Discovery: Deciphering the role of TDP43 regulation of cryptic exons in ALS pathogenesis
Chung, R., Williams, K., Lee, A., Morsch, M., Rayner, S. & Grima, N.
1/10/23 → 30/09/26
Project: Research
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FightMND ECRF: Improving the likelihood of translation of novel degrader technology for the treatment of MND
Rayner, S., Lee, A., Chung, R., Halliday, G., Walker, A. K. & Liu, F.
1/10/23 → 30/09/27
Project: Research
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Cyclin F, Neurodegeneration, and the Pathogenesis of ALS/FTD
Rayner, S. L., Hogan, A., Davidson, J. M., Cheng, F., Luu, L., Morsch, M., Blair, I., Chung, R. & Lee, A., Apr 2024, In: Neuroscientist. 30, 2, p. 214-228 15 p.Research output: Contribution to journal › Review article › peer-review
4 Citations (Scopus) -
Cyclin F can alter the turnover of TDP-43
Rayner, S. L., Hogan, A., Davidson, J. M., Chapman, T., Cheng, F., Luu, L., Wu, S., Zhang, S., Yang, S., Blair, I., Morsch, M., Chung, R. & Lee, A., Mar 2024, In: Neurobiology of Disease. 192, p. 1-10 10 p., 106421.Research output: Contribution to journal › Article › peer-review
Open AccessFile78 Downloads (Pure) -
Modified polypeptides and uses thereof
Chung, R., Lee, A., Rayner, S., Morsch, M. & Luu, L., 20 Jun 2024, IPC No. C07K 14/ 47 A I, Patent No. US2024199713, Priority date 22 Apr 2021, Priority No. AU2021901193Research output: Patent
Open Access -
Modified polypeptides and uses thereof
Chung, R., Lee, A., Rayner, S., Morsch, M. & Luu, L., 28 Feb 2024, IPC No. A61P 25/ 28 A I, A61K 48/00, Patent No. EP4326340, Priority date 22 Apr 2021, Priority No. AU2021901193Research output: Patent
Open Access -
Understanding age-related pathologic changes in TDP-43 functions and the consequence on RNA splicing and signalling in health and disease
Cheng, F., Chapman, T., Zhang, S., Morsch, M., Chung, R., Lee, A. & Rayner, S. L., Apr 2024, In: Ageing Research Reviews. 96, p. 1-15 15 p., 102246.Research output: Contribution to journal › Review article › peer-review
Open AccessFile2 Citations (Scopus)74 Downloads (Pure)