Projects per year
Personal profile
Biography
Professor Graham is Head of Ophthalmology and Visual Science at Macquarie University Faculty of Medicine, and a Visiting Professor at the Save Sight Institute, Sydney University. He practices as a glaucoma subspecialist, with a special interest in early diagnosis and electrophysiology. His research involves mechanisms of optic nerve damage, including vascular, molecular and genetic factors and new imaging techniques for structural analysis and dynamic retinal vascular changes. His research team is studying neurodegenerative pathways with a view to developing neuroprotective therapies for glaucoma and multiple sclerosis.
External positions
Visiting Professor, University of Sydney
2008 → …Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
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Glaucoma
Medicine & Life Sciences
Visual Evoked Potentials
Medicine & Life Sciences
Visual Fields
Medicine & Life Sciences
Visual Field Tests
Medicine & Life Sciences
Optic Neuritis
Medicine & Life Sciences
Multiple Sclerosis
Medicine & Life Sciences
Nerve Fibers
Medicine & Life Sciences
Intraocular Pressure
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2008 2022
Endogenous Rexinoid and Retinoid X receptors as Neuroprotective molecules in Glaucoma
Gupta, V., Graham, S. & Mirzaei, M.
1/01/19 → 31/12/19
Project: Research
Mechanisms for the neuroprotective effects of Siponimod - Is there neuroprotection beyond S1P receptors?
Graham, S., Klistorner, A., Gupta, V. & Mirzaei, M.
13/07/18 → 31/10/20
Project: Other
Targeting neuroserpin-plasmin interactions to protect the retina in glaucoma
Graham, S., Gupta, V., Baker, M., Mirzaei, M. & Magnus, T.
1/01/18 → 31/12/20
Project: Other
Screening the eyes for early diagnosis of Alzheimer's disease
Graham, S. & Golzan, M.
1/07/17 → …
Project: Research
Research Output 1991 2019
Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease
You, Y., Joseph, C., Wang, C., Gupta, V., Liu, S., Yiannikas, C., Chua, B., Chitranshi, N., Shen, T., Dheer, Y., Invernizzi, A., Borotkanics, R., Barnett, M., Graham, S. L. & Klistorner, A., 1 Feb 2019, In : Brain; a journal of neurology. 142, 2, p. 426-442 17 p.Research output: Contribution to journal › Article › Research › peer-review
Demyelinating Diseases
Neurodegenerative Diseases
Radiation
Myelin Sheath
Neuroglia
Differing structural and functional patterns of optic nerve damage in multiple sclerosis and neuromyelitis optica spectrum disorder
Shen, T., You, Y., Arunachalam, S., Fontes, A., Liu, S., Gupta, V., Parratt, J., Wang, C., Barnett, M., Barton, J., Chitranshi, N., Zhu, L., Fraser, C. L., Graham, S. L., Klistorner, A. & Yiannikas, C., Mar 2019, In : Ophthalmology. 126, 3, p. 445-453 9 p.Research output: Contribution to journal › Article › Research › peer-review
Neuromyelitis Optica
Optic Nerve
Multiple Sclerosis
Visual Evoked Potentials
Ganglia
Evidence of Müller glial dysfunction in patients with aquaporin-4 immunoglobulin G–positive neuromyelitis optica spectrum disorder
You, Y., Zhu, L., Zhang, T., Shen, T., Fontes, A., Yiannikas, C., Parratt, J., Barton, J., Schulz, A., Gupta, V., Barnett, M. H., Fraser, C. L., Gillies, M., Graham, S. L. & Klistorner, A., 1 Feb 2019, In : Ophthalmology.Research output: Contribution to journal › Article › Research › peer-review
Aquaporin 4
Neuromyelitis Optica
Neuroglia
Immunoglobulin G
Multiple Sclerosis
Loss of Shp2 rescues BDNF/TrkB signaling and contributes to improved retinal ganglion cell neuroprotection
Chitranshi, N., Dheer, Y., Mirzaei, M., Wu, Y., Salekdeh, G. H., Abbasi, M., Gupta, V., Vander Wall, R., You, Y., Graham, S. L. & Gupta, V., 6 Feb 2019, In : Molecular Therapy. 27, 2, p. 424-441 18 p.Research output: Contribution to journal › Article › Research › peer-review
trkB Receptor
Retinal Ganglion Cells
Glaucoma
Endoplasmic Reticulum Stress
Apoptosis
Molecular docking, dynamics, and pharmacology studies on bexarotene as an agonist of ligand-activated transcription factors, retinoid X receptors
Chitranshi, N., Dheer, Y., Kumar, S., Graham, S. L. & Gupta, V., 11 Feb 2019, In : Journal of Cellular Biochemistry.Research output: Contribution to journal › Article › Research › peer-review
Retinoid X Receptors
Molecular Dynamics Simulation
Transcription Factors
Pharmacology
Ligands
Prizes
Retinal Vessels
Research