Projects per year
Personal profile
Biography
Professor Graham (MBBS, MS, PhD, FRANZCO) is Head of Ophthalmology and Visual Science at Macquarie University Faculty of Medicine, and a Visiting Professor at the Save Sight Institute, Sydney University. He practices as a glaucoma subspecialist, with a special interest in early diagnosis and electrophysiology. His research involves mechanisms of optic nerve damage, including vascular, molecular and genetic factors and new imaging techniques for structural analysis and dynamic retinal vascular changes. His research team is studying neurodegenerative pathways with a view to developing neuroprotective therapies for glaucoma and multiple sclerosis.
External positions
Visiting Professor, University of Sydney
2008 → …
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Novel Protective Effects of Neuropeptide Y for Glaucoma Retina
Basavarajappa, D. (Primary Chief Investigator), Chitranshi, N. (Chief Investigator), Raniga, A. (Chief Investigator), Viswanathan, D. (Chief Investigator), Gupta, V. (Co-Investigator) & Graham, S. L. (Co-Investigator)
1/01/25 → 30/06/26
Project: Research
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CTCS 22 (Flinders led): A randomised controlled trial in genetically at-risk individuals to determine the efficacy of early laser treatment in preventing glaucomatous vision loss
Craig, J., Hewitt, A. W., Graham, S. L., Casson, R., Souzeau, E., Siggs, O. M., McGregor, S., Pesudovs, K., Si, L., Morton, E., Landers, J., Agar, A., White, A., Thomson, D., Kizilersu, A. & Savarirayan, R.
5/05/24 → 4/05/28
Project: Research
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Retinoid-X-receptor Agonists as Novel Neuroprotectants in Glaucoma
Graham, S. L., Gupta, V. & Chitranshi, N.
1/07/23 → 30/06/26
Project: Research
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MRFF (Flinders led): Implementing a novel model of management for glaucoma using polygenic risk profiling
Craig, J., Hewitt, A. W., Siggs, O. M., Souzeau, E., Kitson, A., Harvey, G., Gharahkhani, P., Karnon, J., Mackey, D., Healey, P., White, A. J. R., Lee, S., Casson, R., Graham, S. L., Pesudovs, K., Kaub, P., Landers, J., Yapp, M., Burdon, K. P., Kizilersu, A., Agar, A., MacGregor, S., Keay, L., Hassall, M. & Lawlor, M.
1/06/23 → 31/05/27
Project: Research
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Let there be light- Modified Serpin as a Dual Function Therapeutic Agent in Glaucoma
Gupta, V., Graham, S. L., Rajala, R. V. S., Gupta, V. B., Komaromy, A., Mirzaei, M. & Chitranshi, N.
1/05/23 → 30/04/27
Project: Research
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A multitrait open-angle glaucoma polygenic risk score stratifies risk of glaucoma diagnosis and severity in eyes with pseudoexfoliation
Kolovos, A., Qassim, A., Hassall, M. M., Marshall, H. N., Schmidt, J., Nguyen, T. T., He, W., Mullany, S., Hollitt, G. L., Berry, E. C., Tang, V., Zhou, T., Lake, S., Mills, R., Landers, J., Casson, R. J., Galanopoulos, A., Graham, S. L., Schulz, A. & Healey, P. R. & 13 others, , Aug 2025, In: Ophthalmology. 132, 8, p. 878-887 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)9 Downloads (Pure) -
Correlations between postmortem quantitative MRI parameters and demyelination, axonal loss and gliosis in multiple sclerosis: a systematic review and meta-analysis
Shen, T., Sheriff, S., Qu, Y., Gupta, V. K., Graham, S. L., Klistorner, A., Jia, H., Sun, X. & You, Y., Apr 2025, In: Brain Imaging and Behavior. 19, 2, p. 323-335 13 p.Research output: Contribution to journal › Article › peer-review
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Glial and immune dysregulation in glaucoma independent of retinal ganglion cell loss: a human post-mortem histopathology study
Salkar, A., Palanivel, V., Basavarajappa, D., Mirzaei, M., Schulz, A., Yan, P., Gupta, V., Graham, S. & You, Y., 28 Jun 2025, In: Acta Neuropathologica Communications. 13, 1, p. 1-16 16 p., 141.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Downloads (Pure) -
Retinoid X receptor agonist 9CDHRA mitigates retinal ganglion cell apoptosis and neuroinflammation in a mouse model of glaucoma
Basavarajappa, D., Chitranshi, N., Mirshahvaladi, S. S. O., Gupta, V. B., Palanivel, V., Parrilla, G. E., Salkar, A., Mirzaei, M., Komáromy, A. M., Krezel, W., Graham, S. L. & Gupta, V., 31 Mar 2025, In: FASEB Journal. 39, 6, p. 1-18 18 p., e70465.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)22 Downloads (Pure) -
Retinoid X receptor alpha overexpression protects retinal ganglion cells and modulates inflammatory response in experimental glaucoma
Chitranshi, N., Basavarajappa, D., Palanivel, V., Parrilla, G. E., Gupta, V., Paulo, J. A., Salkar, A., Mirzaei, M., Koronyo-Hamaoui, M., Krezel, W., Graham, S. L. & Gupta, V. K., 27 Aug 2025, (E-pub ahead of print) In: Molecular Therapy.Research output: Contribution to journal › Article › peer-review