20002020

Research output per year

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Research Outputs

2020

CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis

Dobson-Stone, C., Hallupp, M., Shahheydari, H., Ragagnin, A. M. G., Chatterton, Z., Carew-Jones, F., Shepherd, C. E., Stefen, H., Paric, E., Fath, T., Thompson, E. M., Blumbergs, P., Short, C. L., Field, C. D., Panegyres, P. K., Hecker, J., Nicholson, G., Shaw, A. D., Fullerton, J. M., Luty, A. A. & 19 others, Schofield, P. R., Brooks, W. S., Rajan, N., Bennett, M. F., Bahlo, M., Shankaracharya, Landers, J. E., Piguet, O., Hodges, J. R., Halliday, G. M., Topp, S. D., Smith, B. N., Shaw, C. E., McCann, E., Fifita, J. A., Williams, K. L., Atkin, J. D., Blair, I. P. & Kwok, J. B., 1 Mar 2020, In : Brain : a journal of neurology. 143, 3, p. 783-799 17 p.

Research output: Contribution to journalArticle

Decoupling the effects of hydrophilic and hydrophobic moieties at the neuron-nanofibre interface

Martin, A. D., Wojciechowski, J. P., Du, E. Y., Rawal, A., Stefen, H., Au, C. G., Hou, L., Cranfield, C. G., Fath, T., Ittner, L. M. & Thordarson, P., 7 Feb 2020, In : Chemical Science. 11, 5, p. 1375-1382 8 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
3 Downloads (Pure)

Sphingosine 1-phosphate but not Fingolimod protects neurons against excitotoxic cell death by inducing neurotrophic gene expression in astrocytes

Tran, C., Heng, B., Teo, J. D., Humphrey, S. J., Qi, Y., Couttas, T. A., Stefen, H., Brettle, M., Fath, T., Guillemin, G. J. & Don, A. S., Apr 2020, In : Journal of Neurochemistry. 153, 2, p. 173-188 16 p., e14917.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2019

Developmental expression of mutant PFN1 in motor neurons impacts neuronal growth and motor performance of young and adult mice

Brettle, M., Stefen, H., Djordjevic, A., Fok, S. Y. Y., Chan, J. W., van Hummel, A., van der Hoven, J., Przybyla, M., Volkerling, A., Ke, Y. D., Delerue, F., Ittner, L. M. & Fath, T., 27 Sep 2019, In : Frontiers in Molecular Neuroscience. 12, p. 1-12 12 p., 231.

Research output: Contribution to journalArticle

Open Access
File
2 Downloads (Pure)

Sphingosine kinase 2 potentiates amyloid deposition but protects against hippocampal volume loss and demyelination in a mouse model of Alzheimer's disease

Lei, M., Teo, J. D., Song, H., McEwen, H. P., Yup Lee, J., Couttas, T. A., Duncan, T., Chesworth, R., Bertz, J., Przybyla, M., Van Eersel, J., Heng, B., Guillemin, G. J., Ittner, L. M., Fath, T., Garner, B., Ittner, A., Karl, T. & Don, A. S., 27 Nov 2019, In : The Journal of Neuroscience. 39, 48, p. 9645-9659 15 p.

Research output: Contribution to journalArticle

Open Access
File
1 Downloads (Pure)
2018

A novel microfluidic device-vased neurite outgrowth inhibition assay reveals the neurite outgrowth-promoting activity of tropomyosin Tpm3.1 in hippocampal neurons

Stefen, H., Hassanzadeh-Barforoushi, A., Brettle, M., Fok, S., Suchowerska, A. K., Tedla, N., Barber, T., Warkiani, M. E. & Fath, T., Nov 2018, In : Cellular and Molecular Neurobiology. 38, 8, p. 1557-1563 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

Turner, N., Lim, X. Y., Toop, H. D., Osborne, B., Brandon, A. E., Taylor, E. N., Fiveash, C. E., Govindaraju, H., Teo, J. D., McEwen, H. P., Couttas, T. A., Butler, S. M., Das, A., Kowalski, G. M., Bruce, C. R., Hoehn, K. L., Fath, T., Schmitz-Peiffer, C., Cooney, G. J., Montgomery, M. K. & 2 others, Morris, J. C. & Don, A. S., 1 Dec 2018, In : Nature Communications. 9, 1, 14 p., 3165.

Research output: Contribution to journalArticle

Open Access
File
22 Citations (Scopus)
22 Downloads (Pure)

Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice

Tonkin, R. S., Bowles, C., Perera, C. J., Keating, B. A., Makker, P. G. S., Duffy, S. S., Lees, J. G., Tran, C., Don, A. S., Fath, T., Liu, L., O'Carroll, S. J., Nicholson, L. F. B., Green, C. R., Gorrie, C. & Moalem-Taylor, G., 1 Feb 2018, In : Experimental Neurology. 300, p. 1-12 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Expression pattern of the aspartyl-tRNA synthetase DARS in the human brain

Fröhlich, D., Suchowerska, A. K., Voss, C., He, R., Wolvetang, E., von Jonquieres, G., Simons, C., Fath, T., Housley, G. D. & Klugmann, M., 20 Mar 2018, In : Frontiers in Molecular Neuroscience. 11, p. 1-13 13 p., 81.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
5 Downloads (Pure)

Hypoxic postconditioning enhances functional recovery following endothelin-1 induced middle cerebral artery occlusion in conscious rats

Nguyen, H. L., Ruhoff, A. M., Fath, T. & Jones, N. M., 1 Aug 2018, In : Experimental Neurology. 306, p. 177-189 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Peptide nanofiber substrates for long-term culturing of primary neurons

Martin, A. D., Chua, S. W., Au, C. G., Stefen, H., Przybyla, M., Lin, Y., Bertz, J., Thordarson, P., Fath, T., Ke, Y. D. & Ittner, L. M., 1 Aug 2018, In : ACS Applied Materials and Interfaces. 10, 30, p. 25127-25134 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Tropomodulin’s actin-binding abilities are required to modulate dendrite development

Gray, K. T., Stefen, H., Ly, T. N. A., Keller, C. J., Colpan, M., Wayman, G. A., Pate, E., Fath, T. & Kostyukova, A. S., 9 Oct 2018, In : Frontiers in Molecular Neuroscience. 11, p. 1-12 12 p., 357.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
8 Downloads (Pure)

Tropomyosin isoforms have specific effects on the transcriptome of undifferentiated and differentiated B35 neuroblastoma cells

Stefen, H., Suchowerska, A. K., Chen, B. J., Brettle, M., Kuschelewski, J., Gunning, P. W., Janitz, M. & Fath, T., 1 Apr 2018, In : FEBS Open Bio. 8, 4, p. 570-583 14 p.

Research output: Contribution to journalArticle

Open Access
File
15 Downloads (Pure)
2017

Actin regulation by tropomodulin and tropomyosin in neuronal morphogenesis and function

Gray, K. T., Kostyukova, A. S. & Fath, T., 1 Oct 2017, In : Molecular and Cellular Neuroscience. 84, p. 48-57 10 p.

Research output: Contribution to journalReview article

8 Citations (Scopus)

A role for tropomyosins in activity-dependent bulk endocytosis?

Gormal, R., Valmas, N., Fath, T. & Meunier, F., 1 Oct 2017, In : Molecular and Cellular Neuroscience. 84, p. 112-118 7 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
14 Downloads (Pure)

Developmental profiling of tropomyosin expression in mouse brain reveals Tpm4.2 as the major post-synaptic tropomyosin in the mature brain

Suchowerska, A. K., Fok, S., Stefen, H., Gunning, P. W., Hardeman, E. C., Power, J. & Fath, T., 22 Dec 2017, In : Frontiers in Cellular Neuroscience. 11, p. 1-14 14 p., 421.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
8 Downloads (Pure)

Functional characterisation of filamentous actin probe expression in neuronal cells

Patel, S., Fok, S. Y. Y., Stefen, H., Tomanić, T., Parić, E., Herold, R., Brettle, M., Djordjevic, A. & Fath, T., 16 Nov 2017, In : PLoS ONE. 12, 11, p. 1-18 18 p., e0187979.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
16 Downloads (Pure)

In vivo characterization of the aspartyl-tRNA synthetase DARS: homing in on the leukodystrophy HBSL

Fröhlich, D., Suchowerska, A. K., Spencer, Z. H. T., von Jonquieres, G., Klugmann, C. B., Bongers, A., Delerue, F., Stefen, H., Ittner, L. M., Fath, T., Housley, G. D. & Klugmann, M., 1 Jan 2017, In : Neurobiology of Disease. 97, Part A, p. 24-35 12 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
4 Downloads (Pure)

Leukocyte immunoglobulin-like receptor A3 (LILRA3) displays anti-inflammatory and neuro-regenerative functions through interaction with multiple ligands

Tedla, N., An, H., Fath, T., Lord, M. & Bryant, K., 1 May 2017, In : Journal of Immunology. 198, 1 Supplement, 1 p., 221.10.

Research output: Contribution to journalMeeting abstract

Special issue on ‘Cytoskeleton-dependent regulation of neuronal network formation’

Fath, T., Kostyukova, A. S. & Foa, L., 1 Oct 2017, In : Molecular and Cellular Neuroscience. 84, p. 1-3 3 p.

Research output: Contribution to journalEditorial

Tau exacerbates excitotoxic brain damage in an animal model of stroke

Bi, M., Gladbach, A., van Eersel, J., Ittner, A., Przybyla, M., van Hummel, A., Chua, S. W., van der Hoven, J., Lee, W. S., Müller, J., Parmar, J., von Jonquieres, G., Stefen, H., Guccione, E., Fath, T., Housley, G. D., Klugmann, M., Ke, Y. D. & Ittner, L. M., 1 Dec 2017, In : Nature Communications. 8, 1, p. 1-15 15 p., 473.

Research output: Contribution to journalArticle

Open Access
File
41 Citations (Scopus)
18 Downloads (Pure)
2016

ePortfolios, assessment and professional skills in the medical sciences

Polly, P., Vickery, R., Thai, T., Yang, J-L., Fath, T., Herbert, C., Jones, N., Lewis, T., Pather, N., Schibeci, S. & Cox, J., 1 Jan 2016, ePortfolios in Australian Universities. Rowley, J. (ed.). Springer, Springer Nature, p. 47-64 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

ISA model and integrative career development learning in year three science courses

Yang, J. L., Polly, P., Fath, T., Jones, N. & Power, J., 1 Jan 2016, In : International Journal of Science, Mathematics and Technology Learning. 23, 3, p. 33-49 17 p.

Research output: Contribution to journalArticle

Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease

Couttas, T. A., Kain, N., Suchowerska, A. K., Quek, L-E., Turner, N., Fath, T., Garner, B. & Don, A. S., 1 Jul 2016, In : Neurobiology of Aging. 43, p. 89-100 12 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Regulation of the postsynaptic compartment of excitatory synapses by the actin cytoskeleton in health and its disruption in disease

Stefen, H., Chaichim, C., Power, J. & Fath, T., 1 Jan 2016, In : Neural Plasticity. 2016, p. 1-19 19 p., 2371970.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
17 Downloads (Pure)

Soluble LILRA3 promotes neurite outgrowth and synapses formation through a high-affinity interaction with Nogo 66

An, H., Brettle, M., Lee, T., Heng, B., Lim, C. K., Guillemin, G. J., Lord, M. S., Klotzsch, E., Geczy, C. L., Bryant, K., Fath, T. & Tedla, N., 2016, In : Journal of Cell Science. 129, 6, p. 1198-1209 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The only constant is change: next generation materials and medical device design for physical and mental health

Knothe Tate, M. L. & Fath, T., 10 Aug 2016, In : Advanced Healthcare Materials. 5, 15, p. 1840-1843 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Tropomodulin isoforms utilize specific binding functions to modulate dendrite development

Gray, K. T., Suchowerska, A. K., Bland, T., Colpan, M., Wayman, G., Fath, T. & Kostyukova, A. S., 1 Jun 2016, In : Cytoskeleton. 73, 6, p. 316-328 13 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Tropomyosins in the healthy and diseased nervous system

Brettle, M., Patel, S. & Fath, T., 1 Sep 2016, In : Brain Research Bulletin. 126, p. 311-323 13 p.

Research output: Contribution to journalReview article

6 Citations (Scopus)
2015

Amyotrophic lateral sclerosis-associated mutant profilin 1 increases dendritic arborisation and spine formation in primary hippocampal neurons

Brettle, M., Suchowerska, A. K., Chua, S. W., Ittner, L. M. & Fath, T., 16 Nov 2015, In : Neuroscience Letters. 609, p. 223-228 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton

Jalilian, I., Heu, C., Cheng, H., Freittag, H., Desouza, M., Stehn, J. R., Bryce, N. S., Whan, R. M., Hardeman, E. C., Fath, T., Schevzov, G. & Gunning, P. W., 15 May 2015, In : PLoS ONE. 10, 5, p. 1-23 23 p., e0126214.

Research output: Contribution to journalArticle

Open Access
File
28 Citations (Scopus)
2 Downloads (Pure)

Functional analysis of amyotrophic lateral sclerosis-associated mutations of profilin 1 in primary mouse neurons

Brettle, M., Suchowerska, A., Chua, S. W., Ittner, L. & Fath, T., 1 Aug 2015, In : Journal of Neurochemistry. 134, S1, p. 195 1 p., MTU11-05.

Research output: Contribution to journalMeeting abstract

Manipulation of the actin cytoskeleton promotes neurite outgrowth on inhibitory substrates

Fath, T., Brettle, M., Janitz, M. & Gunning, P., 1 Aug 2015, In : Journal of Neurochemistry. 134, S1, p. 311 1 p., WTH10-01.

Research output: Contribution to journalMeeting abstract

Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments

Schevzov, G., Kee, A. J., Wang, B., Sequeira, V. B., Hook, J., Coombes, J. D., Lucas, C. A., Stehn, J. R., Musgrove, E. A., Cretu, A., Assoian, R., Fath, T., Hanoch, T., Seger, R., Pleines, I., Kile, B. T., Hardeman, E. C. & Gunning, P. W., 1 Jul 2015, In : Molecular Biology of the Cell. 26, 13, p. 2475-2490 16 p.

Research output: Contribution to journalArticle

Open Access
File
29 Citations (Scopus)
16 Downloads (Pure)

Synapse function in dementia and neurodegenerative disorders

Sytnyk, V. & Fath, T., 1 Apr 2015, In : Australian Biochemist. 46, 1, p. 16-18 3 p.

Research output: Contribution to journalArticle

The effects of hypoxic postconditioning in a rat model of endothelin-1 induced middle cerebral ischemia

Nguyen, H. L., Fath, T. & Jones, N., 1 Aug 2015, In : Journal of Neurochemistry. 134, S1, p. 294-295 2 p., WTH08-12.

Research output: Contribution to journalMeeting abstract

2014

Cytoskeletal changes in diseases of the nervous system

Suchowerska, A. K. & Fath, T., 1 Feb 2014, In : Frontiers in Biology. 9, 1, p. 5-17 13 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Determining the impact of the actin cytoskeleton on the mechanical properties of cells

Jalilian, I., Schevzov, G., Fath, T., Heu, C., Bischof, L., Vindin, H., Stehn, J. R., Tate, M. K., Hardeman, E. C. & Gunning, P. W., 1 Dec 2014, In : Molecular Biology of the Cell. 25, 25, 1 p., E110.

Research output: Contribution to journalMeeting abstract

Modeling excitotoxic ischemic brain injury of cerebellar Purkinje neurons by intravital and in vitro multi-photon laser scanning microscopy

Craig, A. J., Housley, G. D. & Fath, T., 1 Jan 2014, Laser scanning microscopy and quantitative image analysis of neuronal tissue. Bakota, L. & Brandt, R. (eds.). Humana Press Inc., p. 105-127 23 p. (Neuromethods; vol. 87).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Tropomyosins induce neuritogenesis and determine neurite branching patterns in B35 neuroblastoma cells

Curthoys, N. M., Freittag, H., Connor, A., Desouza, M., Brettle, M., Poljak, A., Hall, A., Hardeman, E., Schevzov, G., Gunning, P. W. & Fath, T., 1 Jan 2014, In : Molecular and Cellular Neuroscience. 58, p. 11-21 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2013

A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells

Stehn, J. R., Haass, N. K., Bonello, T., Desouza, M., Kottyan, G., Treutlein, H., Zeng, J., Nascimento, P. R. B. B., Sequeira, V. B., Butler, T. L., Allanson, M., Fath, T., Hill, T. A., McCluskey, A., Schevzov, G., Palmer, S. J., Hardeman, E. C., Winlaw, D., Reeve, V. E., Dixon, I. & 3 others, Weninger, W., Cripe, T. P. & Gunning, P. W., 15 Aug 2013, In : Cancer Research. 73, 16, p. 5169-5182 14 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Development and implementation of a virtual laboratory for use in a third year anatomy course at the University of NSW

Fath, T., de Permentier, P. J. & Belinson, Z., 3 Apr 2013, In : Clinical Anatomy. 26, 5, p. 645 1 p.

Research output: Contribution to journalMeeting abstract

Tropomodulins and tropomyosins: organizers of cellular microcompartments

Fath, T., 1 Feb 2013, In : Biomolecular Concepts. 4, 1, p. 89-101 13 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)
2012

Antibodies to surface dopamine-2 receptor in autoimmune movement and psychiatric disorders

Dale, R. C., Merheb, V., Pillai, S., Wang, D., Cantrill, L., Murphy, T. K., Ben-Pazi, H., Varadkar, S., Aumann, T. D., Horne, M. K., Church, A. J., Fath, T. & Brilot, F., 1 Jan 2012, In : Brain. 135, 11, p. 3453-3468 16 p.

Research output: Contribution to journalArticle

189 Citations (Scopus)

Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells

Stehn, J. R., Haass, N. K., Bonello, T., Desouza, M., Kottyan, G., Treutlein, H., Zeng, J., Nascimento, P. R., Butler, T., Allanson, M., Fath, T., Hill, T. A., McCluskey, A., Schevzov, G., Palmer, S., Hardeman, E. C., Winlaw, D., Reeve, V. E., Dixon, I., Weninger, W. & 2 others, Cripe, T. P. & Gunning, P., 1 Mar 2012, In : Experimental Dermatology. 21, 3, p. e43 1 p., P254 (V29).

Research output: Contribution to journalMeeting abstract

64 Citations (Scopus)

Functional diversity of actin cytoskeleton in neurons and its regulation by tropomyosin

Schevzov, G., Curthoys, N. M., Gunning, P. W. & Fath, T., 14 Aug 2012, In : International Review of Cell and Molecular Biology. 298, p. 33-94 62 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2011

Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation

Hundelt, M., Fath, T., Selle, K., Oesterwind, K., Jordan, J., Schultz, C., Götz, J., von Engelhardt, J., Monyer, H., Lewejohann, L., Sachser, N., Bakota, L. & Brandt, R., 1 Jun 2011, In : Neurobiology of Aging. 32, 6, p. 991-1006 16 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Functional identity of the gamma tropomyosin gene: implications for embryonic development, reproduction and cell viability

Hook, J., Lemckert, F., Schevzov, G., Fath, T. & Gunning, P., 1 Jan 2011, In : Bioarchitecture. 1, 1, p. 49-59 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

TPM3 and TPM4 gene products segregate to the postsynaptic region of central nervous system synapses

Guven, K., Gunning, P. & Fath, T., 1 Jan 2011, In : Bioarchitecture. 1, 6, p. 284-289 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Tropomodulins are negative regulators of neurite outgrowth

Fath, T., Fischer, R. S., Dehmelt, L., Halpain, S. & Fowler, V. M., 1 Apr 2011, In : European Journal of Cell Biology. 90, 4, p. 291-300 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)