20002020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Outputs

2000

Herpes simplex virus-mediated expression of the axonal protein tau in human model neurons (NT2-N cells)

Fath, T., Eidenmüller, J., Maas, T. & Brandt, R., 15 Jan 2000, In : Microscopy Research and Technique. 48, 2, p. 85-96 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Structural and functional implications of tau hyperphosphorylation: information from phosphorylation-mimicking mutated tau proteins

Eidenmuller, J., Fath, T., Hellwig, A., Reed, J., Sontag, E. & Brandt, R., 8 Nov 2000, In : Biochemistry. 39, 43, p. 13166-13175 10 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)
2001

Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau protein

Eidenmüller, J., Fath, T., Maas, T., Pool, M., Sontag, E. & Brandt, R., 1 Aug 2001, In : Biochemical Journal. 357, 3, p. 759-767 9 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)
2002

Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease

Fath, T., Eidenmüller, J. & Brandt, R., 15 Nov 2002, In : Journal of Neuroscience. 22, 22, p. 9733-9741 9 p.

Research output: Contribution to journalArticle

180 Citations (Scopus)
2004

Tropomodulin and actin pointed-end dynamics in neuronal model systems

Fath, T. & Fowler, V. M., 1 Nov 2004, In : Molecular Biology of the Cell. 15, Supplement, p. 25A 1 p.

Research output: Contribution to journalMeeting abstract

2007

Pseudohyperphosphorylation of tau is sufficient to induce aberrant sprouting and activation of ERK1/2 in transgenic mice

Hundelt, M., Selle, K., Kosfeld, A., Fath, T., Schultz, C., Götz, J., von Engelhardt, J., Monyer, H. & Brandt, R., 2007, In : BMC Neuroscience. 8, Suppl 1, p. P27 1 p.

Research output: Contribution to journalArticle

2008

A new neurotrophic support culture technique for primary neurons

Ke, Y. D., Ittner, L. M., Gunning, P., Gotz, J. & Fath, T., 1 Jul 2008, In : Alzheimer's and Dementia. 4, 4 Supplement, p. T248 1 p., P1-142.

Research output: Contribution to journalMeeting abstract

Divergent regulation of the sarcomere and the cytoskeleton

Schevzov, G., Fath, T., Vrhovski, B., Vlahovich, N., Rajan, S., Hook, J., Joya, J. E., Lemckert, F., Puttur, F., Lin, J. J-C., Hardeman, E. C., Wieczorek, D. F., O'Neill, G. M. & Gunning, P. W., 4 Jan 2008, In : Journal of Biological Chemistry. 283, 1, p. 275-283 9 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response

Götz, J., David, D., Hoerndli, F., Ke, Y. D., Schonrock, N., Wiesner, A., Fath, T., Bokhari, L., Lim, Y-A., Deters, N. & Ittner, L. M., 1 Mar 2008, In : Neurodegenerative Diseases. 5, 3-4, p. 179-181 3 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia

Ittner, L. M., Fath, T., Ke, Y. D., Bi, M., Van Eersel, J., Li, K. M., Gunning, P. & Götz, J., 14 Oct 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 41, p. 15997-16002 6 p.

Research output: Contribution to journalArticle

150 Citations (Scopus)

Parkinsonism and memory impairment in tau transgenic mice with axonal transport defects

Ittner, L. M., Ke, Y. D., Fath, T., Schonrock, N., Gunning, P. & Gotz, J., 1 Jul 2008, In : Alzheimer's and Dementia. 4, 4 Supplement, p. T408 1 p., P2-129.

Research output: Contribution to journalArticle

2009

A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau

Brandt, R., Gergou, A., Wacker, I., Fath, T. & Hutter, H., 1 Jan 2009, In : Neurobiology of Aging. 30, 1, p. 22-33 12 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Intracellular structural compartments, disease and tropomyosins

Schevzov, G., Fath, T. & Gunning, P. W., 1 Dec 2009, In : Current Topics in Pharmacology. 13, 2, p. 1-15 15 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Primary support cultures of hippocampal and substantia nigra neurons

Fath, T., Ke, Y. D., Gunning, P., Götz, J. & Ittner, L. M., 16 Mar 2009, In : Nature Protocols. 4, 1, p. 78-85 8 p.

Research output: Contribution to journalArticle

117 Citations (Scopus)
2010

New aspects of tropomyosin-regulated neuritogenesis revealed by the deletion of Tm5NM1 and 2

Fath, T., Agnes Chan, Y. K., Vrhovski, B., Clarke, H., Curthoys, N., Hook, J., Lemckert, F., Schevzov, G., Tam, P., Watson, C. M., Khoo, P. L. & Gunning, P., 1 Jul 2010, In : European Journal of Cell Biology. 89, 7, p. 489-498 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2011

Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation

Hundelt, M., Fath, T., Selle, K., Oesterwind, K., Jordan, J., Schultz, C., Götz, J., von Engelhardt, J., Monyer, H., Lewejohann, L., Sachser, N., Bakota, L. & Brandt, R., 1 Jun 2011, In : Neurobiology of Aging. 32, 6, p. 991-1006 16 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Functional identity of the gamma tropomyosin gene: implications for embryonic development, reproduction and cell viability

Hook, J., Lemckert, F., Schevzov, G., Fath, T. & Gunning, P., 1 Jan 2011, In : Bioarchitecture. 1, 1, p. 49-59 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

TPM3 and TPM4 gene products segregate to the postsynaptic region of central nervous system synapses

Guven, K., Gunning, P. & Fath, T., 1 Jan 2011, In : Bioarchitecture. 1, 6, p. 284-289 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Tropomodulins are negative regulators of neurite outgrowth

Fath, T., Fischer, R. S., Dehmelt, L., Halpain, S. & Fowler, V. M., 1 Apr 2011, In : European Journal of Cell Biology. 90, 4, p. 291-300 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Tropomyosin isoforms and reagents

Schevzov, G., Whittaker, S. P., Fath, T., Lin, J. J-C. & Gunning, P. W., 1 Jan 2011, In : Bioarchitecture. 1, 4, p. 135-164 30 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Tropomyosins induce neurite formation in B35 neuroblastoma cells and control neurite branching

Curthoys, N., Freittag, H., Connor, A., Desouza, M., Hardeman, E., Gunning, P., Schevzov, G. & Fath, T., 1 Jan 2011, In : Molecular Biology of the Cell. 22, 24, 1 p., 1507.

Research output: Contribution to journalMeeting abstract

2012

Antibodies to surface dopamine-2 receptor in autoimmune movement and psychiatric disorders

Dale, R. C., Merheb, V., Pillai, S., Wang, D., Cantrill, L., Murphy, T. K., Ben-Pazi, H., Varadkar, S., Aumann, T. D., Horne, M. K., Church, A. J., Fath, T. & Brilot, F., 1 Jan 2012, In : Brain. 135, 11, p. 3453-3468 16 p.

Research output: Contribution to journalArticle

194 Citations (Scopus)

Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells

Stehn, J. R., Haass, N. K., Bonello, T., Desouza, M., Kottyan, G., Treutlein, H., Zeng, J., Nascimento, P. R., Butler, T., Allanson, M., Fath, T., Hill, T. A., McCluskey, A., Schevzov, G., Palmer, S., Hardeman, E. C., Winlaw, D., Reeve, V. E., Dixon, I., Weninger, W. & 2 others, Cripe, T. P. & Gunning, P., 1 Mar 2012, In : Experimental Dermatology. 21, 3, p. e43 1 p., P254 (V29).

Research output: Contribution to journalMeeting abstract

65 Citations (Scopus)

Functional diversity of actin cytoskeleton in neurons and its regulation by tropomyosin

Schevzov, G., Curthoys, N. M., Gunning, P. W. & Fath, T., 14 Aug 2012, In : International Review of Cell and Molecular Biology. 298, p. 33-94 62 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2013

A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells

Stehn, J. R., Haass, N. K., Bonello, T., Desouza, M., Kottyan, G., Treutlein, H., Zeng, J., Nascimento, P. R. B. B., Sequeira, V. B., Butler, T. L., Allanson, M., Fath, T., Hill, T. A., McCluskey, A., Schevzov, G., Palmer, S. J., Hardeman, E. C., Winlaw, D., Reeve, V. E., Dixon, I. & 3 others, Weninger, W., Cripe, T. P. & Gunning, P. W., 15 Aug 2013, In : Cancer Research. 73, 16, p. 5169-5182 14 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

Development and implementation of a virtual laboratory for use in a third year anatomy course at the University of NSW

Fath, T., de Permentier, P. J. & Belinson, Z., 3 Apr 2013, In : Clinical Anatomy. 26, 5, p. 645 1 p.

Research output: Contribution to journalMeeting abstract

Tropomodulins and tropomyosins: organizers of cellular microcompartments

Fath, T., 1 Feb 2013, In : Biomolecular Concepts. 4, 1, p. 89-101 13 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)
2014

Cytoskeletal changes in diseases of the nervous system

Suchowerska, A. K. & Fath, T., 1 Feb 2014, In : Frontiers in Biology. 9, 1, p. 5-17 13 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Determining the impact of the actin cytoskeleton on the mechanical properties of cells

Jalilian, I., Schevzov, G., Fath, T., Heu, C., Bischof, L., Vindin, H., Stehn, J. R., Tate, M. K., Hardeman, E. C. & Gunning, P. W., 1 Dec 2014, In : Molecular Biology of the Cell. 25, 25, 1 p., E110.

Research output: Contribution to journalMeeting abstract

Modeling excitotoxic ischemic brain injury of cerebellar Purkinje neurons by intravital and in vitro multi-photon laser scanning microscopy

Craig, A. J., Housley, G. D. & Fath, T., 1 Jan 2014, Laser scanning microscopy and quantitative image analysis of neuronal tissue. Bakota, L. & Brandt, R. (eds.). Humana Press Inc., p. 105-127 23 p. (Neuromethods; vol. 87).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Tropomyosins induce neuritogenesis and determine neurite branching patterns in B35 neuroblastoma cells

Curthoys, N. M., Freittag, H., Connor, A., Desouza, M., Brettle, M., Poljak, A., Hall, A., Hardeman, E., Schevzov, G., Gunning, P. W. & Fath, T., 1 Jan 2014, In : Molecular and Cellular Neuroscience. 58, p. 11-21 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2015

Amyotrophic lateral sclerosis-associated mutant profilin 1 increases dendritic arborisation and spine formation in primary hippocampal neurons

Brettle, M., Suchowerska, A. K., Chua, S. W., Ittner, L. M. & Fath, T., 16 Nov 2015, In : Neuroscience Letters. 609, p. 223-228 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton

Jalilian, I., Heu, C., Cheng, H., Freittag, H., Desouza, M., Stehn, J. R., Bryce, N. S., Whan, R. M., Hardeman, E. C., Fath, T., Schevzov, G. & Gunning, P. W., 15 May 2015, In : PLoS ONE. 10, 5, p. 1-23 23 p., e0126214.

Research output: Contribution to journalArticle

Open Access
File
28 Citations (Scopus)
2 Downloads (Pure)

Functional analysis of amyotrophic lateral sclerosis-associated mutations of profilin 1 in primary mouse neurons

Brettle, M., Suchowerska, A., Chua, S. W., Ittner, L. & Fath, T., 1 Aug 2015, In : Journal of Neurochemistry. 134, S1, p. 195 1 p., MTU11-05.

Research output: Contribution to journalMeeting abstract

Manipulation of the actin cytoskeleton promotes neurite outgrowth on inhibitory substrates

Fath, T., Brettle, M., Janitz, M. & Gunning, P., 1 Aug 2015, In : Journal of Neurochemistry. 134, S1, p. 311 1 p., WTH10-01.

Research output: Contribution to journalMeeting abstract

Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments

Schevzov, G., Kee, A. J., Wang, B., Sequeira, V. B., Hook, J., Coombes, J. D., Lucas, C. A., Stehn, J. R., Musgrove, E. A., Cretu, A., Assoian, R., Fath, T., Hanoch, T., Seger, R., Pleines, I., Kile, B. T., Hardeman, E. C. & Gunning, P. W., 1 Jul 2015, In : Molecular Biology of the Cell. 26, 13, p. 2475-2490 16 p.

Research output: Contribution to journalArticle

Open Access
File
29 Citations (Scopus)
17 Downloads (Pure)

Synapse function in dementia and neurodegenerative disorders

Sytnyk, V. & Fath, T., 1 Apr 2015, In : Australian Biochemist. 46, 1, p. 16-18 3 p.

Research output: Contribution to journalArticle

The effects of hypoxic postconditioning in a rat model of endothelin-1 induced middle cerebral ischemia

Nguyen, H. L., Fath, T. & Jones, N., 1 Aug 2015, In : Journal of Neurochemistry. 134, S1, p. 294-295 2 p., WTH08-12.

Research output: Contribution to journalMeeting abstract

2016

ePortfolios, assessment and professional skills in the medical sciences

Polly, P., Vickery, R., Thai, T., Yang, J-L., Fath, T., Herbert, C., Jones, N., Lewis, T., Pather, N., Schibeci, S. & Cox, J., 1 Jan 2016, ePortfolios in Australian Universities. Rowley, J. (ed.). Springer, Springer Nature, p. 47-64 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

ISA model and integrative career development learning in year three science courses

Yang, J. L., Polly, P., Fath, T., Jones, N. & Power, J., 1 Jan 2016, In : International Journal of Science, Mathematics and Technology Learning. 23, 3, p. 33-49 17 p.

Research output: Contribution to journalArticle

Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease

Couttas, T. A., Kain, N., Suchowerska, A. K., Quek, L-E., Turner, N., Fath, T., Garner, B. & Don, A. S., 1 Jul 2016, In : Neurobiology of Aging. 43, p. 89-100 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Regulation of the postsynaptic compartment of excitatory synapses by the actin cytoskeleton in health and its disruption in disease

Stefen, H., Chaichim, C., Power, J. & Fath, T., 1 Jan 2016, In : Neural Plasticity. 2016, p. 1-19 19 p., 2371970.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
18 Downloads (Pure)

Soluble LILRA3 promotes neurite outgrowth and synapses formation through a high-affinity interaction with Nogo 66

An, H., Brettle, M., Lee, T., Heng, B., Lim, C. K., Guillemin, G. J., Lord, M. S., Klotzsch, E., Geczy, C. L., Bryant, K., Fath, T. & Tedla, N., 2016, In : Journal of Cell Science. 129, 6, p. 1198-1209 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The only constant is change: next generation materials and medical device design for physical and mental health

Knothe Tate, M. L. & Fath, T., 10 Aug 2016, In : Advanced Healthcare Materials. 5, 15, p. 1840-1843 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Tropomodulin isoforms utilize specific binding functions to modulate dendrite development

Gray, K. T., Suchowerska, A. K., Bland, T., Colpan, M., Wayman, G., Fath, T. & Kostyukova, A. S., 1 Jun 2016, In : Cytoskeleton. 73, 6, p. 316-328 13 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Tropomyosins in the healthy and diseased nervous system

Brettle, M., Patel, S. & Fath, T., 1 Sep 2016, In : Brain Research Bulletin. 126, p. 311-323 13 p.

Research output: Contribution to journalReview article

6 Citations (Scopus)
2017

Actin regulation by tropomodulin and tropomyosin in neuronal morphogenesis and function

Gray, K. T., Kostyukova, A. S. & Fath, T., 1 Oct 2017, In : Molecular and Cellular Neuroscience. 84, p. 48-57 10 p.

Research output: Contribution to journalReview article

8 Citations (Scopus)

A role for tropomyosins in activity-dependent bulk endocytosis?

Gormal, R., Valmas, N., Fath, T. & Meunier, F., 1 Oct 2017, In : Molecular and Cellular Neuroscience. 84, p. 112-118 7 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
16 Downloads (Pure)

Developmental profiling of tropomyosin expression in mouse brain reveals Tpm4.2 as the major post-synaptic tropomyosin in the mature brain

Suchowerska, A. K., Fok, S., Stefen, H., Gunning, P. W., Hardeman, E. C., Power, J. & Fath, T., 22 Dec 2017, In : Frontiers in Cellular Neuroscience. 11, p. 1-14 14 p., 421.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
8 Downloads (Pure)

Functional characterisation of filamentous actin probe expression in neuronal cells

Patel, S., Fok, S. Y. Y., Stefen, H., Tomanić, T., Parić, E., Herold, R., Brettle, M., Djordjevic, A. & Fath, T., 16 Nov 2017, In : PLoS ONE. 12, 11, p. 1-18 18 p., e0187979.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
16 Downloads (Pure)