20002020

Research output per year

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Research Outputs

Article

A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau

Brandt, R., Gergou, A., Wacker, I., Fath, T. & Hutter, H., 1 Jan 2009, In : Neurobiology of Aging. 30, 1, p. 22-33 12 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation

Hundelt, M., Fath, T., Selle, K., Oesterwind, K., Jordan, J., Schultz, C., Götz, J., von Engelhardt, J., Monyer, H., Lewejohann, L., Sachser, N., Bakota, L. & Brandt, R., 1 Jun 2011, In : Neurobiology of Aging. 32, 6, p. 991-1006 16 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Amyotrophic lateral sclerosis-associated mutant profilin 1 increases dendritic arborisation and spine formation in primary hippocampal neurons

Brettle, M., Suchowerska, A. K., Chua, S. W., Ittner, L. M. & Fath, T., 16 Nov 2015, In : Neuroscience Letters. 609, p. 223-228 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells

Stehn, J. R., Haass, N. K., Bonello, T., Desouza, M., Kottyan, G., Treutlein, H., Zeng, J., Nascimento, P. R. B. B., Sequeira, V. B., Butler, T. L., Allanson, M., Fath, T., Hill, T. A., McCluskey, A., Schevzov, G., Palmer, S. J., Hardeman, E. C., Winlaw, D., Reeve, V. E., Dixon, I. & 3 others, Weninger, W., Cripe, T. P. & Gunning, P. W., 15 Aug 2013, In : Cancer Research. 73, 16, p. 5169-5182 14 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

A novel microfluidic device-vased neurite outgrowth inhibition assay reveals the neurite outgrowth-promoting activity of tropomyosin Tpm3.1 in hippocampal neurons

Stefen, H., Hassanzadeh-Barforoushi, A., Brettle, M., Fok, S., Suchowerska, A. K., Tedla, N., Barber, T., Warkiani, M. E. & Fath, T., Nov 2018, In : Cellular and Molecular Neurobiology. 38, 8, p. 1557-1563 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Antibodies to surface dopamine-2 receptor in autoimmune movement and psychiatric disorders

Dale, R. C., Merheb, V., Pillai, S., Wang, D., Cantrill, L., Murphy, T. K., Ben-Pazi, H., Varadkar, S., Aumann, T. D., Horne, M. K., Church, A. J., Fath, T. & Brilot, F., 1 Jan 2012, In : Brain. 135, 11, p. 3453-3468 16 p.

Research output: Contribution to journalArticle

194 Citations (Scopus)

A role for tropomyosins in activity-dependent bulk endocytosis?

Gormal, R., Valmas, N., Fath, T. & Meunier, F., 1 Oct 2017, In : Molecular and Cellular Neuroscience. 84, p. 112-118 7 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
16 Downloads (Pure)

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

Turner, N., Lim, X. Y., Toop, H. D., Osborne, B., Brandon, A. E., Taylor, E. N., Fiveash, C. E., Govindaraju, H., Teo, J. D., McEwen, H. P., Couttas, T. A., Butler, S. M., Das, A., Kowalski, G. M., Bruce, C. R., Hoehn, K. L., Fath, T., Schmitz-Peiffer, C., Cooney, G. J., Montgomery, M. K. & 2 others, Morris, J. C. & Don, A. S., 1 Dec 2018, In : Nature Communications. 9, 1, 14 p., 3165.

Research output: Contribution to journalArticle

Open Access
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22 Citations (Scopus)
24 Downloads (Pure)

Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice

Tonkin, R. S., Bowles, C., Perera, C. J., Keating, B. A., Makker, P. G. S., Duffy, S. S., Lees, J. G., Tran, C., Don, A. S., Fath, T., Liu, L., O'Carroll, S. J., Nicholson, L. F. B., Green, C. R., Gorrie, C. & Moalem-Taylor, G., 1 Feb 2018, In : Experimental Neurology. 300, p. 1-12 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton

Jalilian, I., Heu, C., Cheng, H., Freittag, H., Desouza, M., Stehn, J. R., Bryce, N. S., Whan, R. M., Hardeman, E. C., Fath, T., Schevzov, G. & Gunning, P. W., 15 May 2015, In : PLoS ONE. 10, 5, p. 1-23 23 p., e0126214.

Research output: Contribution to journalArticle

Open Access
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28 Citations (Scopus)
2 Downloads (Pure)

CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis

Dobson-Stone, C., Hallupp, M., Shahheydari, H., Ragagnin, A. M. G., Chatterton, Z., Carew-Jones, F., Shepherd, C. E., Stefen, H., Paric, E., Fath, T., Thompson, E. M., Blumbergs, P., Short, C. L., Field, C. D., Panegyres, P. K., Hecker, J., Nicholson, G., Shaw, A. D., Fullerton, J. M., Luty, A. A. & 19 others, Schofield, P. R., Brooks, W. S., Rajan, N., Bennett, M. F., Bahlo, M., Shankaracharya, Landers, J. E., Piguet, O., Hodges, J. R., Halliday, G. M., Topp, S. D., Smith, B. N., Shaw, C. E., McCann, E., Fifita, J. A., Williams, K. L., Atkin, J. D., Blair, I. P. & Kwok, J. B., 1 Mar 2020, In : Brain : a journal of neurology. 143, 3, p. 783-799 17 p.

Research output: Contribution to journalArticle

Decoupling the effects of hydrophilic and hydrophobic moieties at the neuron-nanofibre interface

Martin, A. D., Wojciechowski, J. P., Du, E. Y., Rawal, A., Stefen, H., Au, C. G., Hou, L., Cranfield, C. G., Fath, T., Ittner, L. M. & Thordarson, P., 7 Feb 2020, In : Chemical Science. 11, 5, p. 1375-1382 8 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
4 Downloads (Pure)

Developmental expression of mutant PFN1 in motor neurons impacts neuronal growth and motor performance of young and adult mice

Brettle, M., Stefen, H., Djordjevic, A., Fok, S. Y. Y., Chan, J. W., van Hummel, A., van der Hoven, J., Przybyla, M., Volkerling, A., Ke, Y. D., Delerue, F., Ittner, L. M. & Fath, T., 27 Sep 2019, In : Frontiers in Molecular Neuroscience. 12, p. 1-12 12 p., 231.

Research output: Contribution to journalArticle

Open Access
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2 Downloads (Pure)

Developmental profiling of tropomyosin expression in mouse brain reveals Tpm4.2 as the major post-synaptic tropomyosin in the mature brain

Suchowerska, A. K., Fok, S., Stefen, H., Gunning, P. W., Hardeman, E. C., Power, J. & Fath, T., 22 Dec 2017, In : Frontiers in Cellular Neuroscience. 11, p. 1-14 14 p., 421.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
8 Downloads (Pure)

Divergent regulation of the sarcomere and the cytoskeleton

Schevzov, G., Fath, T., Vrhovski, B., Vlahovich, N., Rajan, S., Hook, J., Joya, J. E., Lemckert, F., Puttur, F., Lin, J. J-C., Hardeman, E. C., Wieczorek, D. F., O'Neill, G. M. & Gunning, P. W., 4 Jan 2008, In : Journal of Biological Chemistry. 283, 1, p. 275-283 9 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Expression pattern of the aspartyl-tRNA synthetase DARS in the human brain

Fröhlich, D., Suchowerska, A. K., Voss, C., He, R., Wolvetang, E., von Jonquieres, G., Simons, C., Fath, T., Housley, G. D. & Klugmann, M., 20 Mar 2018, In : Frontiers in Molecular Neuroscience. 11, p. 1-13 13 p., 81.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
6 Downloads (Pure)

Functional characterisation of filamentous actin probe expression in neuronal cells

Patel, S., Fok, S. Y. Y., Stefen, H., Tomanić, T., Parić, E., Herold, R., Brettle, M., Djordjevic, A. & Fath, T., 16 Nov 2017, In : PLoS ONE. 12, 11, p. 1-18 18 p., e0187979.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
16 Downloads (Pure)

Functional diversity of actin cytoskeleton in neurons and its regulation by tropomyosin

Schevzov, G., Curthoys, N. M., Gunning, P. W. & Fath, T., 14 Aug 2012, In : International Review of Cell and Molecular Biology. 298, p. 33-94 62 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response

Götz, J., David, D., Hoerndli, F., Ke, Y. D., Schonrock, N., Wiesner, A., Fath, T., Bokhari, L., Lim, Y-A., Deters, N. & Ittner, L. M., 1 Mar 2008, In : Neurodegenerative Diseases. 5, 3-4, p. 179-181 3 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Functional identity of the gamma tropomyosin gene: implications for embryonic development, reproduction and cell viability

Hook, J., Lemckert, F., Schevzov, G., Fath, T. & Gunning, P., 1 Jan 2011, In : Bioarchitecture. 1, 1, p. 49-59 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Herpes simplex virus-mediated expression of the axonal protein tau in human model neurons (NT2-N cells)

Fath, T., Eidenmüller, J., Maas, T. & Brandt, R., 15 Jan 2000, In : Microscopy Research and Technique. 48, 2, p. 85-96 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Hypoxic postconditioning enhances functional recovery following endothelin-1 induced middle cerebral artery occlusion in conscious rats

Nguyen, H. L., Ruhoff, A. M., Fath, T. & Jones, N. M., 1 Aug 2018, In : Experimental Neurology. 306, p. 177-189 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

In vivo characterization of the aspartyl-tRNA synthetase DARS: homing in on the leukodystrophy HBSL

Fröhlich, D., Suchowerska, A. K., Spencer, Z. H. T., von Jonquieres, G., Klugmann, C. B., Bongers, A., Delerue, F., Stefen, H., Ittner, L. M., Fath, T., Housley, G. D. & Klugmann, M., 1 Jan 2017, In : Neurobiology of Disease. 97, Part A, p. 24-35 12 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
4 Downloads (Pure)

ISA model and integrative career development learning in year three science courses

Yang, J. L., Polly, P., Fath, T., Jones, N. & Power, J., 1 Jan 2016, In : International Journal of Science, Mathematics and Technology Learning. 23, 3, p. 33-49 17 p.

Research output: Contribution to journalArticle

Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease

Couttas, T. A., Kain, N., Suchowerska, A. K., Quek, L-E., Turner, N., Fath, T., Garner, B. & Don, A. S., 1 Jul 2016, In : Neurobiology of Aging. 43, p. 89-100 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

New aspects of tropomyosin-regulated neuritogenesis revealed by the deletion of Tm5NM1 and 2

Fath, T., Agnes Chan, Y. K., Vrhovski, B., Clarke, H., Curthoys, N., Hook, J., Lemckert, F., Schevzov, G., Tam, P., Watson, C. M., Khoo, P. L. & Gunning, P., 1 Jul 2010, In : European Journal of Cell Biology. 89, 7, p. 489-498 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia

Ittner, L. M., Fath, T., Ke, Y. D., Bi, M., Van Eersel, J., Li, K. M., Gunning, P. & Götz, J., 14 Oct 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 41, p. 15997-16002 6 p.

Research output: Contribution to journalArticle

150 Citations (Scopus)

Parkinsonism and memory impairment in tau transgenic mice with axonal transport defects

Ittner, L. M., Ke, Y. D., Fath, T., Schonrock, N., Gunning, P. & Gotz, J., 1 Jul 2008, In : Alzheimer's and Dementia. 4, 4 Supplement, p. T408 1 p., P2-129.

Research output: Contribution to journalArticle

Peptide nanofiber substrates for long-term culturing of primary neurons

Martin, A. D., Chua, S. W., Au, C. G., Stefen, H., Przybyla, M., Lin, Y., Bertz, J., Thordarson, P., Fath, T., Ke, Y. D. & Ittner, L. M., 1 Aug 2018, In : ACS Applied Materials and Interfaces. 10, 30, p. 25127-25134 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau protein

Eidenmüller, J., Fath, T., Maas, T., Pool, M., Sontag, E. & Brandt, R., 1 Aug 2001, In : Biochemical Journal. 357, 3, p. 759-767 9 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Primary support cultures of hippocampal and substantia nigra neurons

Fath, T., Ke, Y. D., Gunning, P., Götz, J. & Ittner, L. M., 16 Mar 2009, In : Nature Protocols. 4, 1, p. 78-85 8 p.

Research output: Contribution to journalArticle

117 Citations (Scopus)

Pseudohyperphosphorylation of tau is sufficient to induce aberrant sprouting and activation of ERK1/2 in transgenic mice

Hundelt, M., Selle, K., Kosfeld, A., Fath, T., Schultz, C., Götz, J., von Engelhardt, J., Monyer, H. & Brandt, R., 2007, In : BMC Neuroscience. 8, Suppl 1, p. P27 1 p.

Research output: Contribution to journalArticle

Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments

Schevzov, G., Kee, A. J., Wang, B., Sequeira, V. B., Hook, J., Coombes, J. D., Lucas, C. A., Stehn, J. R., Musgrove, E. A., Cretu, A., Assoian, R., Fath, T., Hanoch, T., Seger, R., Pleines, I., Kile, B. T., Hardeman, E. C. & Gunning, P. W., 1 Jul 2015, In : Molecular Biology of the Cell. 26, 13, p. 2475-2490 16 p.

Research output: Contribution to journalArticle

Open Access
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29 Citations (Scopus)
17 Downloads (Pure)

Regulation of the postsynaptic compartment of excitatory synapses by the actin cytoskeleton in health and its disruption in disease

Stefen, H., Chaichim, C., Power, J. & Fath, T., 1 Jan 2016, In : Neural Plasticity. 2016, p. 1-19 19 p., 2371970.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
18 Downloads (Pure)

Soluble LILRA3 promotes neurite outgrowth and synapses formation through a high-affinity interaction with Nogo 66

An, H., Brettle, M., Lee, T., Heng, B., Lim, C. K., Guillemin, G. J., Lord, M. S., Klotzsch, E., Geczy, C. L., Bryant, K., Fath, T. & Tedla, N., 2016, In : Journal of Cell Science. 129, 6, p. 1198-1209 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Sphingosine 1-phosphate but not Fingolimod protects neurons against excitotoxic cell death by inducing neurotrophic gene expression in astrocytes

Tran, C., Heng, B., Teo, J. D., Humphrey, S. J., Qi, Y., Couttas, T. A., Stefen, H., Brettle, M., Fath, T., Guillemin, G. J. & Don, A. S., Apr 2020, In : Journal of Neurochemistry. 153, 2, p. 173-188 16 p., e14917.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Sphingosine kinase 2 potentiates amyloid deposition but protects against hippocampal volume loss and demyelination in a mouse model of Alzheimer's disease

Lei, M., Teo, J. D., Song, H., McEwen, H. P., Yup Lee, J., Couttas, T. A., Duncan, T., Chesworth, R., Bertz, J., Przybyla, M., Van Eersel, J., Heng, B., Guillemin, G. J., Ittner, L. M., Fath, T., Garner, B., Ittner, A., Karl, T. & Don, A. S., 27 Nov 2019, In : The Journal of Neuroscience. 39, 48, p. 9645-9659 15 p.

Research output: Contribution to journalArticle

Open Access
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1 Downloads (Pure)

Structural and functional implications of tau hyperphosphorylation: information from phosphorylation-mimicking mutated tau proteins

Eidenmuller, J., Fath, T., Hellwig, A., Reed, J., Sontag, E. & Brandt, R., 8 Nov 2000, In : Biochemistry. 39, 43, p. 13166-13175 10 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

Synapse function in dementia and neurodegenerative disorders

Sytnyk, V. & Fath, T., 1 Apr 2015, In : Australian Biochemist. 46, 1, p. 16-18 3 p.

Research output: Contribution to journalArticle

Tau exacerbates excitotoxic brain damage in an animal model of stroke

Bi, M., Gladbach, A., van Eersel, J., Ittner, A., Przybyla, M., van Hummel, A., Chua, S. W., van der Hoven, J., Lee, W. S., Müller, J., Parmar, J., von Jonquieres, G., Stefen, H., Guccione, E., Fath, T., Housley, G. D., Klugmann, M., Ke, Y. D. & Ittner, L. M., 1 Dec 2017, In : Nature Communications. 8, 1, p. 1-15 15 p., 473.

Research output: Contribution to journalArticle

Open Access
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41 Citations (Scopus)
18 Downloads (Pure)

Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease

Fath, T., Eidenmüller, J. & Brandt, R., 15 Nov 2002, In : Journal of Neuroscience. 22, 22, p. 9733-9741 9 p.

Research output: Contribution to journalArticle

180 Citations (Scopus)

The only constant is change: next generation materials and medical device design for physical and mental health

Knothe Tate, M. L. & Fath, T., 10 Aug 2016, In : Advanced Healthcare Materials. 5, 15, p. 1840-1843 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

TPM3 and TPM4 gene products segregate to the postsynaptic region of central nervous system synapses

Guven, K., Gunning, P. & Fath, T., 1 Jan 2011, In : Bioarchitecture. 1, 6, p. 284-289 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Tropomodulin isoforms utilize specific binding functions to modulate dendrite development

Gray, K. T., Suchowerska, A. K., Bland, T., Colpan, M., Wayman, G., Fath, T. & Kostyukova, A. S., 1 Jun 2016, In : Cytoskeleton. 73, 6, p. 316-328 13 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Tropomodulins are negative regulators of neurite outgrowth

Fath, T., Fischer, R. S., Dehmelt, L., Halpain, S. & Fowler, V. M., 1 Apr 2011, In : European Journal of Cell Biology. 90, 4, p. 291-300 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Tropomodulin’s actin-binding abilities are required to modulate dendrite development

Gray, K. T., Stefen, H., Ly, T. N. A., Keller, C. J., Colpan, M., Wayman, G. A., Pate, E., Fath, T. & Kostyukova, A. S., 9 Oct 2018, In : Frontiers in Molecular Neuroscience. 11, p. 1-12 12 p., 357.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
8 Downloads (Pure)

Tropomyosin isoforms and reagents

Schevzov, G., Whittaker, S. P., Fath, T., Lin, J. J-C. & Gunning, P. W., 1 Jan 2011, In : Bioarchitecture. 1, 4, p. 135-164 30 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Tropomyosin isoforms have specific effects on the transcriptome of undifferentiated and differentiated B35 neuroblastoma cells

Stefen, H., Suchowerska, A. K., Chen, B. J., Brettle, M., Kuschelewski, J., Gunning, P. W., Janitz, M. & Fath, T., 1 Apr 2018, In : FEBS Open Bio. 8, 4, p. 570-583 14 p.

Research output: Contribution to journalArticle

Open Access
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15 Downloads (Pure)

Tropomyosins induce neuritogenesis and determine neurite branching patterns in B35 neuroblastoma cells

Curthoys, N. M., Freittag, H., Connor, A., Desouza, M., Brettle, M., Poljak, A., Hall, A., Hardeman, E., Schevzov, G., Gunning, P. W. & Fath, T., 1 Jan 2014, In : Molecular and Cellular Neuroscience. 58, p. 11-21 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
Chapter

ePortfolios, assessment and professional skills in the medical sciences

Polly, P., Vickery, R., Thai, T., Yang, J-L., Fath, T., Herbert, C., Jones, N., Lewis, T., Pather, N., Schibeci, S. & Cox, J., 1 Jan 2016, ePortfolios in Australian Universities. Rowley, J. (ed.). Springer, Springer Nature, p. 47-64 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)