Research output per year
Research output per year
Personal profile
Biography
Tyler finished his honours at UNSW with Marc Wilkins in 2019 and has since been working as a research assistant in proteomics and molecular biology. His current role involves creating new synthetic DNA constructs for expression in zebrafish for subsequent live cell imaging, as well as proteomic studies focused on protein interactions in MND. Coming from a background in synthetic biology, Tyler is inspired by the likes of Craig Venter and hopes to apply these concepts to the study of MND to generate novel therapeutics.
Education/Academic qualification
Molecular and Cell Biology, Bachelor of Advanced Science (Hon), Phosphorylation of Serine 2 Responsible for the Regulation of Histone Methyltransferase SET2, UNSW Sydney
1 Jan 2016 → 21 Dec 2019
Award Date: 30 Jan 2020
External positions
Research Assistant, Walter and Eliza Hall Institute of Medical Research
Nov 2019 → Aug 2020
Fingerprint
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Cyclin F can alter the turnover of TDP-43
Rayner, S. L., Hogan, A., Davidson, J. M., Chapman, T., Cheng, F., Luu, L., Wu, S., Zhang, S., Yang, S., Blair, I., Morsch, M., Chung, R. & Lee, A., Mar 2024, In: Neurobiology of Disease. 192, p. 1-10 10 p., 106421.Research output: Contribution to journal › Article › peer-review
Open AccessFile54 Downloads (Pure) -
Understanding age-related pathologic changes in TDP-43 functions and the consequence on RNA splicing and signalling in health and disease
Cheng, F., Chapman, T., Zhang, S., Morsch, M., Chung, R., Lee, A. & Rayner, S. L., Apr 2024, In: Ageing Research Reviews. 96, p. 1-15 15 p., 102246.Research output: Contribution to journal › Review article › peer-review
Open AccessFile33 Downloads (Pure) -
The post-translational modification SUMO affects TDP-43 phase separation, compartmentalization, and aggregation in a zebrafish model
Maurel, C., Scherer, N. M., Hogan, A., Vidal-Itriago, A., Don, E. K., Radford, R., Chapman, T., Cull, S., Vourc’h, P., Chung, R., Lee, A. & Morsch, M., 14 Aug 2022, (Submitted) 30 p. (bioRxiv).Research output: Working paper › Preprint
File70 Downloads (Pure) -
Post-translational modification analysis of Saccharomyces cerevisiae histone methylation enzymes reveals phosphorylation sites of regulatory potential
Separovich, R. J., Wong, M. W. M., Chapman, T. R., Slavich, E., Hamey, J. J. & Wilkins, M. R., 2021, In: Journal of Biological Chemistry. 296, p. 1-18 18 p., 100192.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)56 Downloads (Pure) -
Unbiased label-free quantitative proteomics of cells expressing amyotrophic lateral sclerosis (ALS) mutations in CCNF reveals activation of the apoptosis pathway: a workflow to screen pathogenic gene mutations
Cheng, F., Luca, A. D., Hogan, A. L., Rayner, S. L., Davidson, J. M., Watchon, M., Stevens, C. H., Muñoz, S. S., Ooi, L., Yerbury, J. J., Don, E. K., Fifita, J. A., Villalva, M. D., Suddull, H., Chapman, T. R., Hedl, T. J., Walker, A. K., Yang, S., Morsch, M., Shi, B., & 4 others, 27 Apr 2021, In: Frontiers in Molecular Neuroscience. 14, p. 1-18 18 p., 627740.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)67 Downloads (Pure)