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Personal profile


Dr. Gupta is NHMRC Dementia Leadership Fellow and NHMRC career development fellowship awardee. He is "Vision Neurodegeneration" group leader, and neurobiologist with a research focus on identifying the mechanisms underlying retinal neurodegeneration in various disease conditions. Dr. Gupta is a Fellow of the Higher Education Academy, UK (FHEA) and a Fellow of the Linnean Society of London (FLS).

He has research background in the field of cell and molecular biology, cloning and generation of transgenic mice models, biochemistry, yeast and mammalian genomics and visual electrophysiology. He has extensively used retina as a model to investigate mechanisms underlying retinal disorders such as glaucoma and macular degeneration and brain neurodegenerative conditions such as Alzheimer’s disease.

More recently, he has carried out targeted gene therapy studies in retina to modulate neurotrophin signalling and protect the retinal neurons in glaucoma. Dr. Gupta has previously undergone extensive postdoctoral training at University of Geneva, Switzerland and Dean McGee Eye Institute, USA. He has secured competitive grants and published more than 75 articles. He recently identified pathological accumulation of amyloid beta protein in the retina in both Alzheimer’s disease and glaucoma animal models and in human post-mortem tissues.

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  • 2 Similar Profiles
Glaucoma Medicine & Life Sciences
Retina Medicine & Life Sciences
Retinal Ganglion Cells Medicine & Life Sciences
Brain-Derived Neurotrophic Factor Medicine & Life Sciences
trkB Receptor Medicine & Life Sciences
Cyclic Nucleotide-Gated Cation Channels Medicine & Life Sciences
Proteins Medicine & Life Sciences
Amyloid Medicine & Life Sciences

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Projects 2013 2023

Research Outputs 2010 2020

Complement pathway in Alzheimer's pathology and retinal neurodegenerative disorders: the road ahead

Mirzaei, M., Deng, L., Gupta, V. B., Graham, S. & Gupta, V., 1 Feb 2020, In : Neural Regeneration Research. 15, 2, p. 257-258 2 p.

Research output: Contribution to journalReview articleResearchpeer-review

Open Access
Open Access
Vertebrate Photoreceptor Cells
Oxidative Phosphorylation
Photoreceptor Cells
Alzheimer Disease

Association between BDNF Val66Met polymorphism and optic neuritis damage in neuromyelitis optica spectrum disorder

Shen, T., Gupta, V., Yiannikas, C., Klistorner, A., Graham, S. L. & You, Y., 19 Nov 2019, In : Frontiers in Neuroscience. 13, p. 1-6 6 p., 1236.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Neuromyelitis Optica
Optic Neuritis
Brain-Derived Neurotrophic Factor
Visual Evoked Potentials
Nerve Fibers

Clinically relevant post-translational modification analyses: maturing workflows and bioinformatics tools

Pascovici, D., Wu, J. X., McKay, M. J., Joseph, C., Noor, Z., Kamath, K., Wu, Y., Ranganathan, S., Gupta, V. & Mirzaei, M., 1 Jan 2019, In : International Journal of Molecular Sciences. 20, 1, p. 1-30 30 p., 16.

Research output: Contribution to journalReview articleResearchpeer-review

Open Access
Post Translational Protein Processing
Computational Biology

Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease

You, Y., Joseph, C., Wang, C., Gupta, V., Liu, S., Yiannikas, C., Chua, B., Chitranshi, N., Shen, T., Dheer, Y., Invernizzi, A., Borotkanics, R., Barnett, M., Graham, S. L. & Klistorner, A., 1 Feb 2019, In : Brain; a journal of neurology. 142, 2, p. 426-442 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Demyelinating Diseases
Neurodegenerative Diseases
Myelin Sheath