Vivek Gupta

Dr

20102020
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Personal profile

Biography

Dr. Gupta is NHMRC Dementia Leadership Fellow and NHMRC career development fellowship awardee. He is "Vision Neurodegeneration" group leader, and neurobiologist with a research focus on identifying the mechanisms underlying retinal neurodegeneration in various disease conditions. He has research background in the field of cell and molecular biology, cloning and generation of transgenic mice models, biochemistry, yeast and mammalian genomics and visual electrophysiology. He has extensively used retina as a model to investigate mechanisms underlying retinal disorders such as glaucoma and macular degeneration and brain neurodegenerative conditions such as Alzheimer’s disease.

More recently, he has carried out targeted gene therapy studies in retina to modulate neurotrophin signalling and protect the retinal neurons in glaucoma. Dr. Gupta has previously undergone extensive postdoctoral training at University of Geneva, Switzerland and Dean McGee Eye Institute, USA. He has secured competitive grants and published more than 60 articles. He recently identified pathological accumulation of amyloid beta protein in the retina in both Alzheimer’s disease and glaucoma animal models and in human post-mortem tissues.

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Retinal Ganglion Cells Medicine & Life Sciences
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Brain-Derived Neurotrophic Factor Medicine & Life Sciences
Proteins Medicine & Life Sciences
Proteomics Medicine & Life Sciences

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Projects 2013 2020

Research Output 2010 2018

Open Access
File
Brain-Derived Neurotrophic Factor
Neurodegenerative Diseases
Valine
Methionine
Glaucoma
Retinoid X Receptors
Endoplasmic Reticulum Stress
Retinoid X Receptor gamma
Retinoid X Receptor beta
Brain

Differing structural and functional patterns of optic nerve damage in multiple sclerosis and neuromyelitis optica spectrum disorder

Shen, T., You, Y., Arunachalam, S., Fontes, A., Liu, S., Gupta, V., Parratt, J., Wang, C., Barnett, M., Barton, J., Chitranshi, N., Zhu, L., Fraser, C. L., Graham, S. L., Klistorner, A. & Yiannikas, C. 27 Jul 2018 In : Ophthalmology.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Optic Nerve
Multiple Sclerosis
Visual Evoked Potentials
Ganglia

Discovery of novel cell surface markers for purification of embryonic dopamine progenitors for transplantation in Parkinson's disease animal models

Fathi, A., Mirzaei, M., Dolatyar, B., Sharifitabar, M., Bayat, M., Shahbazi, E., Lee, J., Javan, M., Zhang, S-C., Gupta, V., Lee, B., Haynes, P. A., Baharvand, H. & Salekdeh, G. H. 1 Sep 2018 In : Molecular and Cellular Proteomics. 17, 9, p. 1670-1684 15 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Contactin 2
Stem cells
Purification
Parkinson Disease

Distinct changes in the proteome profile of endometrial tissues in polycystic ovary syndrome compared with healthy fertile women

Amjadi, F., Mehdizadeh, M., Ashrafi, M., Nasrabadi, D., Taleahmad, S., Mirzaei, M., Gupta, V., Salekdeh, G. H. & Aflatoonian, R. Aug 2018 In : Reproductive BioMedicine Online. 37, 2, p. 184-200 17 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Proteome
Proteins
14-3-3 Proteins
Luteal Phase