Projects per year
Personal profile
Biography
Dr. Vivek Gupta is an Associate Professor and Head of the Vision Science group at Macquarie University. A recipient of both NHMRC Dementia Leadership and Career Development Fellowships, he is a neurobiologist whose research centers on the mechanisms of retinal neurodegeneration in various diseases.
His diverse research background spans cell and molecular biology, cloning and transgenic mouse models, biochemistry, clinical studies, public health and data analysis, yeast and mammalian genomics, pharmacological compound development and testing, visual electrophysiology, and gene therapy. He has cultivated a broad collaborative network across Australia, India, the USA, and Europe.
Dr. Gupta's group uses the retina as a model to investigate mechanisms underlying retinal disorders like glaucoma and macular degeneration, as well as neurodegenerative conditions such as Alzheimer's disease. His research also explores retinal and optic nerve changes, correlating them with brain imaging and neuropsychological parameters in healthy aging and Alzheimer's patients. He is actively involved in targeted retinal gene therapy studies, aiming to modulate signaling pathways and protect neurons in disease states.
Following extensive postdoctoral training in Switzerland and the USA, Dr. Gupta has secured competitive grants and published over 170 articles. His recent work has identified the pathological accumulation of amyloid beta protein in the retina in Alzheimer's disease and glaucoma, including in human post-mortem tissue.
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Collaborations and top research areas from the last five years
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Retinoid-X-receptor Agonists as Novel Neuroprotectants in Glaucoma
Graham, S. L., Gupta, V. & Chitranshi, N.
1/07/23 → 30/06/26
Project: Research
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Let there be light- Modified Serpin as a Dual Function Therapeutic Agent in Glaucoma
Gupta, V., Graham, S. L., Rajala, R. V. S., Gupta, V. B., Komaromy, A., Mirzaei, M. & Chitranshi, N.
1/05/23 → 30/04/27
Project: Research
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UNSW led: Vascular Contributions to Dementia (VCD-CRE) - a transformative approach to reducing the burden of cognitive disorders
Sachdev, P., Parsons, M. W., Brodtmann, A., Levi, C. R., Samaras, K., Kovacic, J., O'Sullivan, M., Butcher, K., Bivard, A. & Gupta, V.
9/06/22 → 31/10/26
Project: Research
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The effects of Alzheimer¿s disease on the Eye: Developing ocular Biomarkers.
1/01/18 → …
Project: Research
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Nuclear Receptor N R2 B1 Targeting In Glaucoma Via Nutritional Approach
Gupta, V., Graham, S. L., Mirzaei, M. & Palanivel, V.
15/02/24 → 15/02/25
Project: Research
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Correlations between postmortem quantitative MRI parameters and demyelination, axonal loss and gliosis in multiple sclerosis: a systematic review and meta-analysis
Shen, T., Sheriff, S., Qu, Y., Gupta, V. K., Graham, S. L., Klistorner, A., Jia, H., Sun, X. & You, Y., Apr 2025, In: Brain Imaging and Behavior. 19, 2, p. 323-335 13 p.Research output: Contribution to journal › Article › peer-review
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Global, regional, and national burden of upper respiratory infections and otitis media, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021
GBD 2021 Upper Respiratory Infections Otitis Media Collaborators, Jan 2025, In: The Lancet Infectious Diseases. 25, 1, p. 36-51 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus) -
Retinoid X receptor agonist 9CDHRA mitigates retinal ganglion cell apoptosis and neuroinflammation in a mouse model of glaucoma
Basavarajappa, D., Chitranshi, N., Mirshahvaladi, S. S. O., Gupta, V. B., Palanivel, V., Parrilla, G. E., Salkar, A., Mirzaei, M., Komáromy, A. M., Krezel, W., Graham, S. L. & Gupta, V., 31 Mar 2025, In: FASEB Journal. 39, 6, p. 1-18 18 p., e70465.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A comprehensive review and androgen deprivation therapy and its impact on Alzheimer's disease risk in older men with prostate cancer
Singh, M., Agarwal, V., Pancham, P., Jindal, D., Agarwal, S., Rai, S. N., Singh, S. K. & Gupta, V., 2024, In: Degenerative Neurological and Neuromuscular Disease. 14, p. 33-46 14 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
A comprehensive update on genetic inheritance, epigenetic factors, associated pathology, and recent therapeutic intervention by gene therapy in schizophrenia
Rachana, R., Devtalla, H., Rana, K., Panda, S. P., Agrawal, A., Kadyan, S., Jindal, D., Pancham, P., Yadav, D., Jha, N. K., Jha, S. K., Gupta, V. & Singh, M., Jan 2024, In: Chemical Biology and Drug Design. 103, 1, p. 1-24 24 p., e14374.Research output: Contribution to journal › Review article › peer-review