Projects per year
Personal profile
Biography
Dr. Gupta is NHMRC Dementia Leadership Fellow and NHMRC career development fellowship awardee. He is "Vision Neurodegeneration" group leader, and neurobiologist with a research focus on identifying the mechanisms underlying retinal neurodegeneration in various disease conditions. Dr. Gupta is a Fellow of the Higher Education Academy, UK (FHEA) and a Fellow of the Linnean Society of London (FLS).
He has research background in the field of cell and molecular biology, cloning and generation of transgenic mice models, biochemistry, yeast and mammalian genomics and visual electrophysiology. He has extensively used retina as a model to investigate mechanisms underlying retinal disorders such as glaucoma and macular degeneration and brain neurodegenerative conditions such as Alzheimer’s disease.
More recently, he has carried out targeted gene therapy studies in retina to modulate neurotrophin signalling and protect the retinal neurons in glaucoma. Dr. Gupta has previously undergone extensive postdoctoral training at University of Geneva, Switzerland and Dean McGee Eye Institute, USA. He has secured competitive grants and published more than 75 articles. He recently identified pathological accumulation of amyloid beta protein in the retina in both Alzheimer’s disease and glaucoma animal models and in human post-mortem tissues.
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Projects
Retinoid X receptors and Rexinoids: Harnessing their Neuroprotective Effects in the Glaucoma
Gupta, V., Graham, S. L., Krezel, W., Chitranshi, N., Mirzaei, M. & Wilkins, M.
1/07/20 → 30/06/23
Project: Other
Mechanisms for the neuroprotective effects of Siponimod - Is there neuroprotection beyond S1P receptors?
Graham, S. L., Klistorner, A., Gupta, V. & Mirzaei, M.
13/07/18 → 31/10/20
Project: Other
Targeting neuroserpin-plasmin interactions to protect the retina in glaucoma
Graham, S. L., Gupta, V., Baker, M. S., Mirzaei, M. & Magnus, T.
1/01/18 → 31/12/20
Project: Other
Research Outputs
Amyloid-beta peptide neurotoxicity in human neuronal cells is associated with modulation of insulin-like growth factor transport, lysosomal machinery and extracellular matrix receptor interactions
Deng, L., Haynes, P. A., Wu, Y., Amirkhani, A., Kamath, K. S., Wu, J. X., Pushpitha, K., Gupta, V., Graham, S., Gupta, V. K. & Mirzaei, M., Nov 2020, In : Neural Regeneration Research. 15, 11, p. 2131-2142 12 p.Research output: Contribution to journal › Article
Open Access
File
Caveolin-1 ablation imparts partial protection against inner retinal injury in experimental glaucoma and reduces apoptotic activation
Abbasi, M., Gupta, V. K., Chitranshi, N., Gupta, V. B., Mirzaei, M., Dheer, Y., Garthwaite, L., Zaw, T., Parton, R. G., You, Y. & Graham, S. L., 23 Jun 2020, In : Molecular Neurobiology. 26 p.Research output: Contribution to journal › Article
Complement pathway in Alzheimer's pathology and retinal neurodegenerative disorders: the road ahead
Mirzaei, M., Deng, L., Gupta, V. B., Graham, S. & Gupta, V., 1 Feb 2020, In : Neural Regeneration Research. 15, 2, p. 257-258 2 p.Research output: Contribution to journal › Review article
Open Access
File
1
Citation
(Scopus)
4
Downloads
(Pure)
Amyloid β induces early changes in the ribosomal machinery, cytoskeletal organization and oxidative phosphorylation in retinal photoreceptor cells
Deng, L., Pushpitha, K., Joseph, C., Gupta, V., Rajput, R., Chitranshi, N., Dheer, Y., Amirkhani, A., Kamath, K., Pascovici, D., Wu, J. X., Salekdeh, G. H., Haynes, P. A., Graham, S. L., Gupta, V. K. & Mirzaei, M., 22 Feb 2019, In : Frontiers in Molecular Neuroscience. 12, p. 1-14 14 p., 24.Research output: Contribution to journal › Article
Open Access
File
2
Citations
(Scopus)
12
Downloads
(Pure)
Association between BDNF Val66Met polymorphism and optic neuritis damage in neuromyelitis optica spectrum disorder
Shen, T., Gupta, V., Yiannikas, C., Klistorner, A., Graham, S. L. & You, Y., 19 Nov 2019, In : Frontiers in Neuroscience. 13, p. 1-6 6 p., 1236.Research output: Contribution to journal › Article
Open Access
File
1
Downloads
(Pure)