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Personal profile

Biography

Dr. Gupta is NHMRC Dementia Leadership Fellow and NHMRC career development fellowship awardee. He is "Vision Neurodegeneration" group leader, and neurobiologist with a research focus on identifying the mechanisms underlying retinal neurodegeneration in various disease conditions. Dr. Gupta is a Fellow of the Higher Education Academy, UK (FHEA) and a Fellow of the Linnean Society of London (FLS).

He has research background in the field of cell and molecular biology, cloning and generation of transgenic mice models, biochemistry, yeast and mammalian genomics and visual electrophysiology. He has extensively used retina as a model to investigate mechanisms underlying retinal disorders such as glaucoma and macular degeneration and brain neurodegenerative conditions such as Alzheimer’s disease.

More recently, he has carried out targeted gene therapy studies in retina to modulate neurotrophin signalling and protect the retinal neurons in glaucoma. Dr. Gupta has previously undergone extensive postdoctoral training at University of Geneva, Switzerland and Dean McGee Eye Institute, USA. He has secured competitive grants and published more than 75 articles. He recently identified pathological accumulation of amyloid beta protein in the retina in both Alzheimer’s disease and glaucoma animal models and in human post-mortem tissues.

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Glaucoma Medicine & Life Sciences
Retina Medicine & Life Sciences
Retinal Ganglion Cells Medicine & Life Sciences
trkB Receptor Medicine & Life Sciences
Brain-Derived Neurotrophic Factor Medicine & Life Sciences
Cyclic Nucleotide-Gated Cation Channels Medicine & Life Sciences
Proteins Medicine & Life Sciences
Amyloid Medicine & Life Sciences

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Projects 2013 2020

Research Outputs 2010 2019

Open Access
File
Vertebrate Photoreceptor Cells
Oxidative Phosphorylation
Amyloid
Photoreceptor Cells
Alzheimer Disease

Clinically relevant post-translational modification analyses: maturing workflows and bioinformatics tools

Pascovici, D., Wu, J. X., McKay, M. J., Joseph, C., Noor, Z., Kamath, K., Wu, Y., Ranganathan, S., Gupta, V. & Mirzaei, M., 1 Jan 2019, In : International Journal of Molecular Sciences. 20, 1, p. 1-30 30 p., 16.

Research output: Contribution to journalReview articleResearchpeer-review

Open Access
File
Workflow
Post Translational Protein Processing
Bioinformatics
Computational Biology
Proteins

Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease

You, Y., Joseph, C., Wang, C., Gupta, V., Liu, S., Yiannikas, C., Chua, B., Chitranshi, N., Shen, T., Dheer, Y., Invernizzi, A., Borotkanics, R., Barnett, M., Graham, S. L. & Klistorner, A., 1 Feb 2019, In : Brain; a journal of neurology. 142, 2, p. 426-442 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Demyelinating Diseases
Neurodegenerative Diseases
Radiation
Myelin Sheath
Neuroglia

Differing structural and functional patterns of optic nerve damage in multiple sclerosis and neuromyelitis optica spectrum disorder

Shen, T., You, Y., Arunachalam, S., Fontes, A., Liu, S., Gupta, V., Parratt, J., Wang, C., Barnett, M., Barton, J., Chitranshi, N., Zhu, L., Fraser, C. L., Graham, S. L., Klistorner, A. & Yiannikas, C., Mar 2019, In : Ophthalmology. 126, 3, p. 445-453 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Neuromyelitis Optica
Optic Nerve
Multiple Sclerosis
Visual Evoked Potentials
Ganglia

Evidence of Müller glial dysfunction in patients with aquaporin-4 immunoglobulin G–positive neuromyelitis optica spectrum disorder

You, Y., Zhu, L., Zhang, T., Shen, T., Fontes, A., Yiannikas, C., Parratt, J., Barton, J., Schulz, A., Gupta, V., Barnett, M. H., Fraser, C. L., Gillies, M., Graham, S. L. & Klistorner, A., 1 Jun 2019, In : Ophthalmology. 126, 6, p. 801-810 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Aquaporin 4
Neuromyelitis Optica
Neuroglia
Immunoglobulin G
Multiple Sclerosis