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Vivek Gupta

Dr

 https://orcid.org/0000-0002-0202-7843
20102023

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Personal profile

Biography

Dr. Gupta is NHMRC Dementia Leadership Fellow and NHMRC career development fellowship awardee. He is "Vision Neurodegeneration" group leader, and neurobiologist with a research focus on identifying the mechanisms underlying retinal neurodegeneration in various disease conditions. Dr. Gupta is a Fellow of the Higher Education Academy, UK (FHEA) and a Fellow of the Linnean Society of London (FLS).

He has research background in the field of cell and molecular biology, cloning and generation of transgenic mice models, biochemistry, yeast and mammalian genomics and visual electrophysiology. He has extensively used retina as a model to investigate mechanisms underlying retinal disorders such as glaucoma and macular degeneration and brain neurodegenerative conditions such as Alzheimer’s disease.

More recently, he has carried out targeted gene therapy studies in retina to modulate neurotrophin signalling and protect the retinal neurons in glaucoma. Dr. Gupta has previously undergone extensive postdoctoral training at University of Geneva, Switzerland and Dean McGee Eye Institute, USA. He has secured competitive grants and published more than 75 articles. He recently identified pathological accumulation of amyloid beta protein in the retina in both Alzheimer’s disease and glaucoma animal models and in human post-mortem tissues.

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Projects

Mechanisms for the neuroprotective effects of Siponimod - Is there neuroprotection beyond S1P receptors?

Graham, S. L., Klistorner, A., Gupta, V. & Mirzaei, M.

13/07/18 → 31/10/20

Project: Other

Targeting neuroserpin-plasmin interactions to protect the retina in glaucoma

Graham, S. L., Gupta, V., Baker, M. S., Mirzaei, M. & Magnus, T.

1/01/18 → 31/12/20

Project: Other

Determining the role of commonly occurring genetic variant of human Brain Derived Neurotrophic Factor (BDNF) in the healthy and glaucoma retinas using a transgenic knock-in mouse model

Gupta, V., Mirzaei, M., Graham, S. L. & Haynes, P.

1/01/17 → …

Project: Research

Retinoid X receptors and Rexinoids: Harnessing their Neuroprotective Effects in the Glaucoma

Gupta, V., Graham, S. L., Krezel, W., Chitranshi, N., Mirzaei, M. & Wilkins, M.

1/07/20 → 30/06/23

Project: Other

MQ SAFETY NET: Retinoid X receptors and Rexinoids: Harnessing their Neuroprotective effects in the Glaucoma

Gupta, V.

1/01/19 → 31/12/19

Project: Research

Research Outputs

Complement pathway in Alzheimer's pathology and retinal neurodegenerative disorders: the road ahead

Mirzaei, M., Deng, L., Gupta, V. B., Graham, S. & Gupta, V., 1 Feb 2020, In : Neural Regeneration Research. 15, 2, p. 257-258 2 p.

Research output: Contribution to journal › Review article

Open Access
File
4 Downloads (Pure)

Amyloid β induces early changes in the ribosomal machinery, cytoskeletal organization and oxidative phosphorylation in retinal photoreceptor cells

Deng, L., Pushpitha, K., Joseph, C., Gupta, V., Rajput, R., Chitranshi, N., Dheer, Y., Amirkhani, A., Kamath, K., Pascovici, D., Wu, J. X., Salekdeh, G. H., Haynes, P. A., Graham, S. L., Gupta, V. K. & Mirzaei, M., 22 Feb 2019, In : Frontiers in Molecular Neuroscience. 12, p. 1-14 14 p., 24.

Research output: Contribution to journal › Article

Open Access
File
    • 1 Citation (Scopus)
    8 Downloads (Pure)

    Association between BDNF Val66Met polymorphism and optic neuritis damage in neuromyelitis optica spectrum disorder

    Shen, T., Gupta, V., Yiannikas, C., Klistorner, A., Graham, S. L. & You, Y., 19 Nov 2019, In : Frontiers in Neuroscience. 13, p. 1-6 6 p., 1236.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 1 Downloads (Pure)

    Clinically relevant post-translational modification analyses: maturing workflows and bioinformatics tools

    Pascovici, D., Wu, J. X., McKay, M. J., Joseph, C., Noor, Z., Kamath, K., Wu, Y., Ranganathan, S., Gupta, V. & Mirzaei, M., 1 Jan 2019, In : International Journal of Molecular Sciences. 20, 1, p. 1-30 30 p., 16.

    Research output: Contribution to journal › Review article

    Open Access
    File
    • 7 Citations (Scopus)
    148 Downloads (Pure)

    Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease

    You, Y., Joseph, C., Wang, C., Gupta, V., Liu, S., Yiannikas, C., Chua, B., Chitranshi, N., Shen, T., Dheer, Y., Invernizzi, A., Borotkanics, R., Barnett, M., Graham, S. L. & Klistorner, A., 1 Feb 2019, In : Brain; a journal of neurology. 142, 2, p. 426-442 17 p.

    Research output: Contribution to journal › Article

    • 14 Citations (Scopus)