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Personal profile


Dr. Gupta is NHMRC Dementia Leadership Fellow and NHMRC career development fellowship awardee. He is "Vision Neurodegeneration" group leader, and neurobiologist with a research focus on identifying the mechanisms underlying retinal neurodegeneration in various disease conditions. Dr. Gupta is a Fellow of the Higher Education Academy, UK (FHEA) and a Fellow of the Linnean Society of London (FLS).

He has research background in the field of cell and molecular biology, cloning and generation of transgenic mice models, biochemistry, yeast and mammalian genomics and visual electrophysiology. He has extensively used retina as a model to investigate mechanisms underlying retinal disorders such as glaucoma and macular degeneration and brain neurodegenerative conditions such as Alzheimer’s disease.

More recently, he has carried out targeted gene therapy studies in retina to modulate neurotrophin signalling and protect the retinal neurons in glaucoma. Dr. Gupta has previously undergone extensive postdoctoral training at University of Geneva, Switzerland and Dean McGee Eye Institute, USA. He has secured competitive grants and published more than 75 articles. He recently identified pathological accumulation of amyloid beta protein in the retina in both Alzheimer’s disease and glaucoma animal models and in human post-mortem tissues.

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Research Outputs

Open Access
  • Caveolin-1 ablation imparts partial protection against inner retinal injury in experimental glaucoma and reduces apoptotic activation

    Abbasi, M., Gupta, V. K., Chitranshi, N., Gupta, V. B., Mirzaei, M., Dheer, Y., Garthwaite, L., Zaw, T., Parton, R. G., You, Y. & Graham, S. L., 23 Jun 2020, In : Molecular Neurobiology. 26 p.

    Research output: Contribution to journalArticle

  • Complement pathway in Alzheimer's pathology and retinal neurodegenerative disorders: the road ahead

    Mirzaei, M., Deng, L., Gupta, V. B., Graham, S. & Gupta, V., 1 Feb 2020, In : Neural Regeneration Research. 15, 2, p. 257-258 2 p.

    Research output: Contribution to journalReview article

    Open Access
    1 Citation (Scopus)
    4 Downloads (Pure)
    Open Access
  • 2 Citations (Scopus)
    12 Downloads (Pure)

    Association between BDNF Val66Met polymorphism and optic neuritis damage in neuromyelitis optica spectrum disorder

    Shen, T., Gupta, V., Yiannikas, C., Klistorner, A., Graham, S. L. & You, Y., 19 Nov 2019, In : Frontiers in Neuroscience. 13, p. 1-6 6 p., 1236.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Downloads (Pure)