Projects per year
Personal profile
Biography
Vivek Gupta is Assoc. Professor, NHMRC Dementia Leadership Fellow and has been an NHMRC career development fellowship awardee. He is "Vision Neurodegeneration" group leader, and neurobiologist with a research focus on identifying the mechanisms underlying retinal neurodegeneration in various disease conditions.
He has research background in the field of cell and molecular biology, cloning and generation of transgenic mice models, biochemistry, yeast and mammalian genomics and visual electrophysiology. His group extensively uses retina as a model to investigate mechanisms underlying retinal disorders such as glaucoma and macular degeneration and brain neurodegenerative conditions such as Alzheimer’s disease. He is also studying the retinal and optic nerve changes and its correlation with brain imaging and neuropsychological parameters in healthy ageing and Alzheimer’s subjects.
More recently, he has carried out targeted gene therapy studies in retina to modulate neurotrophin signalling and protect the retinal neurons in glaucoma. Dr. Gupta has previously undergone extensive postdoctoral training at University of Geneva, Switzerland and Dean McGee Eye Institute, USA. He has secured competitive grants and published >130 articles. He recently identified pathological accumulation of amyloid beta protein in the retina in Alzheimer’s disease and glaucoma animal models and in human post-mortem tissues.
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Collaborations and top research areas from the last five years
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Let there be light- Modified Serpin as a Dual Function Therapeutic Agent in Glaucoma
Gupta, V., Graham, S. L., Rajala, R. V. S., Gupta, V. B., Komaromy, A., Mirzaei, M. & Chitranshi, N.
1/05/23 → 30/04/27
Project: Research
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UNSW led: Vascular Contributions to Dementia (VCD-CRE) - a transformative approach to reducing the burden of cognitive disorders
Sachdev, P., Parsons, M. W., Brodtmann, A., Levi, C. R., Samaras, K., Kovacic, J., O'Sullivan, M., Butcher, K., Bivard, A. & Gupta, V.
9/06/22 → 31/10/26
Project: Research
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The effects of Alzheimer¿s disease on the Eye: Developing ocular Biomarkers.
1/01/18 → …
Project: Research
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Amyloid and Tau targeting to protect Retinal Ganglion Cell and Optic Nerve in glaucoma
Gupta, V., Graham, S. L. & Mirzaei, M.
1/01/22 → 31/12/22
Project: Research
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Retinoid X receptors and Rexinoids: Harnessing their Neuroprotective Effects in the Glaucoma
Gupta, V., Graham, S. L., Krezel, W., Chitranshi, N., Mirzaei, M. & Wilkins, M.
1/07/20 → 30/06/23
Project: Other
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Anti-inflammatory effects of siponimod in a mouse model of excitotoxicity-induced retinal injury
Basavarajappa, D., Gupta, V., Chitranshi, N., Viswanathan, D., Gupta, V., Vander Wall, R., Palanivel, V., Mirzaei, M., You, Y., Klistorner, A. & Graham, S. L., 5 Aug 2023, (E-pub ahead of print) In: Molecular Neurobiology. 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Apolipoprotein ε in brain and retinal neurodegenerative diseases
Abyadeh, M., Gupta, V., Paulo, J. A., Sheriff, S., Shadfar, S., Fitzhenry, M., Amirkhani, A., Gupta, V., Salekdeh, G. H., Haynes, P. A., Graham, S. L. & Mirzaei, M., 22 Apr 2023, (E-pub ahead of print) In: Aging and Disease.Research output: Contribution to journal › Review article › peer-review
Open Access -
Chitosan modified 5-fluorouracil nanostructured lipid carriers for treatment of diabetic retinopathy in rats: a new dimension to an anticancer drug
Sharma, D. S., Wadhwa, S., Gulati, M., Kumar, B., Chitranshi, N., Gupta, V. K., Alrouji, M., Alhajlah, S., AlOmeir, O., Vishwas, S., Khursheed, R., Saini, S., Kumar, A., Parveen, S. R., Gupta, G., Zacconi, F., Chellappan, D. K., Morris, A., Loebenberg, R., Dua, K., & 1 others , 1 Jan 2023, In: International Journal of Biological Macromolecules. 224, p. 810-830 21 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
Computational refinement identifies functional destructive single nucleotide polymorphisms associated with human retinoid X receptor gene
Sarkar, S., Gupta, V. K., Sharma, S., Shen, T., Gupta, V., Mirzaei, M., Graham, S. L. & Chitranshi, N., 4 Mar 2023, In: Journal of Biomolecular Structure and Dynamics. 41, 4, p. 1458-1478 21 p.Research output: Contribution to journal › Article › peer-review
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Extracellular vesicles as reconfigurable therapeutics for eye diseases: promises and hurdles
Shekari, F., Abyadeh, M., Meyfour, A., Mirzaei, M., Chitranshi, N., Gupta, V., Graham, S. L. & Salekdeh, G. H., Jun 2023, In: Progress in Neurobiology. 225, p. 1-14 14 p., 102437.Research output: Contribution to journal › Review article › peer-review