Projects per year
Personal profile
Biography
Dr. Gupta is NHMRC Dementia Leadership Fellow and NHMRC career development fellowship awardee. He is "Vision Neurodegeneration" group leader, and neurobiologist with a research focus on identifying the mechanisms underlying retinal neurodegeneration in various disease conditions. Dr. Gupta is a Fellow of the Higher Education Academy, UK (FHEA) and a Fellow of the Linnean Society of London (FLS).
He has research background in the field of cell and molecular biology, cloning and generation of transgenic mice models, biochemistry, yeast and mammalian genomics and visual electrophysiology. He has extensively used retina as a model to investigate mechanisms underlying retinal disorders such as glaucoma and macular degeneration and brain neurodegenerative conditions such as Alzheimer’s disease.
More recently, he has carried out targeted gene therapy studies in retina to modulate neurotrophin signalling and protect the retinal neurons in glaucoma. Dr. Gupta has previously undergone extensive postdoctoral training at University of Geneva, Switzerland and Dean McGee Eye Institute, USA. He has secured competitive grants and published more than 75 articles. He recently identified pathological accumulation of amyloid beta protein in the retina in both Alzheimer’s disease and glaucoma animal models and in human post-mortem tissues.
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Projects 2013 2020
Endogenous Rexinoid and Retinoid X receptors as Neuroprotective molecules in Glaucoma
Gupta, V., Graham, S. & Mirzaei, M.
1/01/19 → 31/12/19
Project: Research
Preparative Ultracentrifuge
Wang, Y., Packer, N., Paulsen, I., Willows, R., Atwell, B., Sunna, A., Brown, L., Andersen, M., Gupta, V. & Mirzaei, M.
1/01/19 → 31/12/19
Project: Other
MQ SAFETY NET: Retinoid X receptors and Rexinoids: Harnessing their Neuroprotective effects in the Glaucoma
1/01/19 → 31/12/19
Project: Research
Mechanisms for the neuroprotective effects of Siponimod - Is there neuroprotection beyond S1P receptors?
Graham, S., Klistorner, A., Gupta, V. & Mirzaei, M.
13/07/18 → 31/10/20
Project: Other
Targeting neuroserpin-plasmin interactions to protect the retina in glaucoma
Graham, S., Gupta, V., Baker, M., Mirzaei, M. & Magnus, T.
1/01/18 → 31/12/20
Project: Other
Research Outputs 2010 2020
Complement pathway in Alzheimer's pathology and retinal neurodegenerative disorders: the road ahead
Mirzaei, M., Deng, L., Gupta, V. B., Graham, S. & Gupta, V., 1 Feb 2020, In : Neural Regeneration Research. 15, 2, p. 257-258 2 p.Research output: Contribution to journal › Review article › Research › peer-review
Amyloid β induces early changes in the ribosomal machinery, cytoskeletal organization and oxidative phosphorylation in retinal photoreceptor cells
Deng, L., Pushpitha, K., Joseph, C., Gupta, V., Rajput, R., Chitranshi, N., Dheer, Y., Amirkhani, A., Kamath, K., Pascovici, D., Wu, J. X., Salekdeh, G. H., Haynes, P. A., Graham, S. L., Gupta, V. K. & Mirzaei, M., 22 Feb 2019, In : Frontiers in Molecular Neuroscience. 12, 14 p., 24.Research output: Contribution to journal › Article › Research › peer-review
Clinically relevant post-translational modification analyses: maturing workflows and bioinformatics tools
Pascovici, D., Wu, J. X., McKay, M. J., Joseph, C., Noor, Z., Kamath, K., Wu, Y., Ranganathan, S., Gupta, V. & Mirzaei, M., 1 Jan 2019, In : International Journal of Molecular Sciences. 20, 1, p. 1-30 30 p., 16.Research output: Contribution to journal › Review article › Research › peer-review
Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease
You, Y., Joseph, C., Wang, C., Gupta, V., Liu, S., Yiannikas, C., Chua, B., Chitranshi, N., Shen, T., Dheer, Y., Invernizzi, A., Borotkanics, R., Barnett, M., Graham, S. L. & Klistorner, A., 1 Feb 2019, In : Brain; a journal of neurology. 142, 2, p. 426-442 17 p.Research output: Contribution to journal › Article › Research › peer-review
Differing structural and functional patterns of optic nerve damage in multiple sclerosis and neuromyelitis optica spectrum disorder
Shen, T., You, Y., Arunachalam, S., Fontes, A., Liu, S., Gupta, V., Parratt, J., Wang, C., Barnett, M., Barton, J., Chitranshi, N., Zhu, L., Fraser, C. L., Graham, S. L., Klistorner, A. & Yiannikas, C., Mar 2019, In : Ophthalmology. 126, 3, p. 445-453 9 p.Research output: Contribution to journal › Article › Research › peer-review