Projects per year
Personal profile
Biography
Associate Professor Yazi Ke is the Deputy Director (Operations) of the Dementia Research Centre and Associate Professor in the Department of Biomedical Sciences of the Faculty of Medicine and Health Sciences at Macquarie University. After obtaining her PhD (Medicine) from University of Sydney (USyd) in Dec 2009, Yazi became a postdoctoral research associate at the Brain and Mind Research Institute, USyd (2010-2013). In July 2013, she moved to University of NSW (UNSW) to join the Dementia Research Unit headed by Prof. Lars Ittner as a research-only Lecturer with an ongoing ARC DECRA fellowship (2013-2016). During her time at UNSW, she was promoted to Senior Lecturer (July 2017) and is a successful recipient of the NHMRC Career Development Fellowship (R.D. Wright Biomedical; 2017-2020).
Research interests
Yazi has made seminal contributions throughout her research career to our current understanding of disease processes in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Her research program and interests includes:
- Developing and characterising new and improved models of FTD and ALS using both traditional transgenesis and AAV approaches
- Deciphering the functions of pathogenic mutations in neurodegenerative diseases
Education/Academic qualification
Neuroscience, PhD, University of Sydney
Fingerprint Dive into the research topics where Yazi Ke is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 12 Similar Profiles
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
Clearance of TDP-43 by PROteolysis TArgeting Chimera (PROTAC) dual targeting to treat amyotrophic lateral sclerosis (ALS)
Lee, A., Rayner, S., Martin, A., van Hummel, A., Morsch, M., Shi, B., Ke, Y., Ittner, L. & Chung, R.
4/05/20 → 3/05/21
Project: Research
Novel pathomechanisms and therapeutic targets in neurodegenerative diseases
1/12/18 → 30/09/20
Project: Other
Site-specific Tau Phosphorylation to Treat and Understand Alzheimer’s Disease
Ittner, A., Ke, Y., Poljak, A., Ittner, L. & Klugmann, M.
1/11/18 → 31/12/20
Project: Other
The Role of LIM Domain Kinase 1 in the Pathogenesis of Alzheimer’s Disease
Ke, Y., Ittner, A., Tan, R. H., Halliday, G., Krill, J., Ittner, L., Klugmann, M., Kassiou, M. & Gunning, P.
1/11/18 → 31/12/20
Project: Other
The role of TDP-43 pathology-associated astrocytosis in Motor Neuron Disease.
1/11/18 → 30/04/19
Project: Other
Research Outputs
BioID analysis of the cyclin F interactome reveals that ALS-variant cyclin F alters the homeostasis of paraspeckle-associated proteins
Rayner, S. L., Cheng, F., Yang, S., Grima, N., Ke, Y. D., Au, C. G., Morsch, M., Luca, A. D., Davidson, J. M., Molloy, M. P., Shi, B., Ittner, L. M., Blair, I., Chung, R. S. & Lee, A., 1 May 2020, (In preparation) In : bioRxiv.Research output: Contribution to journal › Article
Contribution of endogenous antibodies to learning deficits and astrocytosis in human P301S mutant tau transgenic mice
van der Hoven, J., van Hummel, A., Przybyla, M., Asih, P., Gajwani, M., Feiten, A., Ke, Y., Ittner, A., Van Eersel, J. & Ittner, L., May 2020, (Accepted/In press) In : Scientific Reports.Research output: Contribution to journal › Article
Neurodegeneration and motor deficits in the absence of astrogliosis upon transgenic mutant TDP-43 expression in mature mice
Chan, G., van Hummel, A., van der Hoven, J., Ittner, L. M. & Ke, Y. D., 16 Apr 2020, (Accepted/In press) In : American Journal of Pathology.Research output: Contribution to journal › Article
Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature
Przybyla, M., Van Eersel, J., van Hummel, A., van der Hoven, J., Sabale, M., Harasta, A., Müller, J., Gajwani, M., Prikas, E., Mueller, T., Stevens, C. H., Power, J., Housley, G. D., Karl, T., Kassiou, M., Ke, Y. D., Ittner, A. & Ittner, L. M., Jun 2020, In : Brain. 143, 6, p. 1889-1904 16 p.Research output: Contribution to journal › Article
Adeno-associated virus-based Alzheimer's disease mouse models and potential new therapeutic avenues
Ittner, L. M., Klugmann, M. & Ke, Y. D., 1 Sep 2019, In : British Journal of Pharmacology. 176, 18, p. 3649-3665 17 p.Research output: Contribution to journal › Review article
4
Citations
(Scopus)
Prizes
UNSW School of Medical Sciences New Researcher of the Year 2015
Yazi Ke (Recipient), 14 Dec 2015
Prize