Yazi Ke

Associate Professor

  • 2576 Citations
  • 20 h-Index
20062020
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Personal profile

Biography

Associate Professor Yazi Ke is the Deputy Director (Operations) of the Dementia Research Centre and Associate Professor in the Department of Biomedical Sciences of the Faculty of Medicine and Health Sciences at Macquarie University. After obtaining her PhD (Medicine) from University of Sydney (USyd) in Dec 2009, Yazi became a postdoctoral research associate at the Brain and Mind Research Institute, USyd (2010-2013). In July 2013, she moved to University of NSW (UNSW) to join the Dementia Research Unit headed by Prof. Lars Ittner as a research-only Lecturer with an ongoing ARC DECRA fellowship (2013-2016). During her time at UNSW, she was promoted to Senior Lecturer (July 2017) and is a successful recipient of the NHMRC Career Development Fellowship (R.D. Wright Biomedical; 2017-2020). 

Research interests

Yazi has made seminal contributions throughout her research career to our current understanding of disease processes in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Her research program and interests includes:

  • Developing and characterising new and improved models of FTD and ALS using both traditional transgenesis and AAV approaches
  • Deciphering the functions of pathogenic mutations in neurodegenerative diseases

Education/Academic qualification

Neuroscience, PhD, University of Sydney

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Projects 2018 2020

The Role of LIM Domain Kinase 1 in the Pathogenesis of Alzheimer’s Disease

Ke, Y., Ittner, A., Tan, R. H., Halliday, G., Krill, J., Ittner, L., Klugmann, M., Kassiou, M. & Gunning, P.

1/11/1831/12/20

Project: Other

Research Outputs 2006 2019

Adeno-associated virus-based Alzheimer's disease mouse models and potential new therapeutic avenues

Ittner, L. M., Klugmann, M. & Ke, Y. D., 1 Sep 2019, In : British Journal of Pharmacology. 176, 18, p. 3649-3665 17 p.

Research output: Contribution to journalReview articleResearchpeer-review

Dependovirus
Alzheimer Disease
Genetic Therapy
Gene Transfer Techniques
Therapeutics

CNS cell type-specific gene profiling of P301S tau transgenic mice identifies genes dysregulated by progressive tau accumulation

Ke, Y. D., Chan, G., Stefanoska, K., Au, C., Bi, M., Müller, J., Przybyla, M., Feiten, A., Prikas, E., Halliday, G. M., Piguet, O., Kiernan, M. C., Kassiou, M., Hodges, J. R., Loy, C. T., Mattick, J. S., Ittner, A., Kril, J. J., Sutherland, G. T. & Ittner, L. M., 20 Sep 2019, In : Journal of Biological Chemistry. 294, 38, p. 14149-14162 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Neurology
Transgenic Mice
Central Nervous System
Genes
Brain

Developmental expression of mutant PFN1 in motor neurons impacts neuronal growth and motor performance of young and adult mice

Brettle, M., Stefen, H., Djordjevic, A., Fok, S. Y. Y., Chan, J. W., van Hummel, A., van der Hoven, J., Przybyla, M., Volkerling, A., Ke, Y. D., Delerue, F., Ittner, L. M. & Fath, T., 27 Sep 2019, In : Frontiers in Molecular Neuroscience. 12, p. 1-12 12 p., 231.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Profilins
Motor Neurons
Young Adult
Amyotrophic Lateral Sclerosis
Transgenic Mice

Alzheimer’s disease and frontotemporal lobar degeneration: mouse models

Ittner, L. M., Lee, W. S., Stefanoska, K., Asih, P. R. & Ke, Y. D., 1 Jan 2018, NeurodegeneratIve diseases: clinical aspects, molecular genetics and biomarkers. Galimberti, D. & Scarpini, E. (eds.). Second ed. Springer, Springer Nature, p. 187-219 33 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Frontotemporal Lobar Degeneration
Alzheimer Disease
Genes
Knockout Mice
Transgenic Mice

An N-terminal motif unique to primate tau enables differential protein–protein interactions

Stefanoska, K., Volkerling, A., Bertz, J., Poljak, A., Ke, Y. D., Ittner, L. M. & Ittner, A., 9 Mar 2018, In : Journal of Biological Chemistry. 293, 10, p. 3710-3719 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Primates
tau Proteins
Proteins
Synaptotagmin I
Synapsins

Prizes

Medical Schools
Research Personnel
Medical Schools