Projects per year
Personal profile
Biography
Associate Professor Yazi Ke is the Deputy Director (Operations) of the Dementia Research Centre and Associate Professor in the Department of Biomedical Sciences of the Faculty of Medicine and Health Sciences at Macquarie University. After obtaining her PhD (Medicine) from University of Sydney (USyd) in Dec 2009, Yazi became a postdoctoral research associate at the Brain and Mind Research Institute, USyd (2010-2013). In July 2013, she moved to University of NSW (UNSW) to join the Dementia Research Unit headed by Prof. Lars Ittner as a research-only Lecturer with an ongoing ARC DECRA fellowship (2013-2016). During her time at UNSW, she was promoted to Senior Lecturer (July 2017) and is a successful recipient of the NHMRC Career Development Fellowship (R.D. Wright Biomedical; 2017-2020).
Research interests
Yazi has made seminal contributions throughout her research career to our current understanding of disease processes in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Her research program and interests includes:
- Developing and characterising new and improved models of FTD and ALS using both traditional transgenesis and AAV approaches
- Deciphering the functions of pathogenic mutations in neurodegenerative diseases
Education/Academic qualification
Neuroscience, PhD, University of Sydney
Award Date: 14 Dec 2009
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Targeting pathogenic TAR DNA-binding protein 43 to treat frontotemporal dementia and motor neuron disease
Ke, Y., van Hummel, A., Ariawan, D., Ittner, L. & Martin, A.
1/01/21 → 31/12/23
Project: Research
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Clearance of TDP-43 by PROteolysis TArgeting Chimera (PROTAC) dual targeting to treat amyotrophic lateral sclerosis (ALS)
Lee, A., Rayner, S., Martin, A., van Hummel, A., Morsch, M., Shi, B., Ke, Y., Ittner, L. & Chung, R.
4/05/20 → 3/05/21
Project: Research
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Novel pathomechanisms and therapeutic targets in neurodegenerative diseases
1/12/18 → 30/09/20
Project: Other
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The Role of LIM Domain Kinase 1 in the Pathogenesis of Alzheimer’s Disease
Ke, Y., Ittner, A., Tan, R. H., Halliday, G., Krill, J., Ittner, L., Klugmann, M., Kassiou, M. & Gunning, P.
1/11/18 → 31/12/20
Project: Other
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Site-specific Tau Phosphorylation to Treat and Understand Alzheimer’s Disease
Ittner, A., Ke, Y., Poljak, A., Ittner, L. & Klugmann, M.
1/11/18 → 31/12/20
Project: Other
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ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ
Rayner, S. L., Cheng, F., Hogan, A. L., Grima, N., Yang, S., Ke, Y. D., Au, C. G., Morsch, M., De Luca, A., Davidson, J. M., Molloy, M. P., Shi, B., Ittner, L. M., Blair, I., Chung, R. S. & Lee, A., 1 Jun 2021, In: Human Molecular Genetics. 30, 11, p. 971-984 14 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
Overexpression of tropomyosin isoform tpm3.1 does not alter synaptic function in hippocampal neurons
Chaichim, C., Tomanic, T., Stefen, H., Paric, E., Gamaroff, L., Suchowerska, A. K., Gunning, P. W., Ke, Y. D., Fath, T. & Power, J., 1 Sep 2021, In: International Journal of Molecular Sciences. 22, 17, p. 1-16 16 p., 9303.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Downloads (Pure) -
Pathological manifestation of human endogenous retrovirus K in frontotemporal dementia
Phan, K., He, Y., Fu, Y., Dzamko, N., Bhatia, S., Gold, J., Rowe, D., Ke, Y. D., Ittner, L., Hodges, J. R., Piguet, O., Kiernan, M. C., Halliday, G. M. & Scott Kim, W., 9 Dec 2021, In: Communications Medicine. 1, p. 1-11 11 p., 60.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Downloads (Pure) -
Rapid initiation of cell cycle reentry processes protects neurons from amyloid-β toxicity
Ippati, S., Deng, Y., Hoven, J. V. D., Heu, C., Hummel, A. V., Chua, S. W., Paric, E., Chan, G., Feiten, A., Fath, T., Ke, Y. D., Haass, N. K. & Ittner, L. M., 23 Mar 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 12, p. 1-9 9 p., e2011876118.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
Sex differences in Alzheimer’s disease animal models
Ippati, S., Ittner, L. M. & Ke, Y. D., 1 Jan 2021, Sex and gender differences in Alzheimer’s disease: Women’s Brain Project. Ferretti, M. T., Schumacher Dimech, A. & Santuccione Chadha, A. (eds.). San Diego: Elsevier, p. 3-22 20 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Prizes
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UNSW School of Medical Sciences New Researcher of the Year 2015
Ke, Yazi (Recipient), 14 Dec 2015
Prize
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