Projects per year
Personal profile
Biography
Associate Professor Yazi Ke is the Deputy Director (Operations) of the Dementia Research Centre and Associate Professor in the Department of Biomedical Sciences of the Faculty of Medicine and Health Sciences at Macquarie University. After obtaining her PhD (Medicine) from University of Sydney (USyd) in Dec 2009, Yazi became a postdoctoral research associate at the Brain and Mind Research Institute, USyd (2010-2013). In July 2013, she moved to University of NSW (UNSW) to join the Dementia Research Unit headed by Prof. Lars Ittner as a research-only Lecturer with an ongoing ARC DECRA fellowship (2013-2016). During her time at UNSW, she was promoted to Senior Lecturer (July 2017) and is a successful recipient of the NHMRC Career Development Fellowship (R.D. Wright Biomedical; 2017-2020).
Research interests
Yazi has made seminal contributions throughout her research career to our current understanding of disease processes in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Her research program and interests includes:
- Developing and characterising new and improved models of FTD and ALS using both traditional transgenesis and AAV approaches
- Deciphering the functions of pathogenic mutations in neurodegenerative diseases
Education/Academic qualification
Neuroscience, PhD, University of Sydney
Award Date: 14 Dec 2009
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Network
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2022 NHMRC Ideas: Inhibition failure in Alzheimer's disease
Ittner, L., van der Hoven, J., Deng, Y., Forrest, S., Ke, Y. & Kovacs, G.
1/01/23 → 31/12/26
Project: Research
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Autologous cell therapy for Alzheimer's disease and related dementias
1/06/22 → 15/11/23
Project: Research
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Targeting pathogenic TAR DNA-binding protein 43 to treat frontotemporal dementia and motor neuron disease
Ke, Y., van Hummel, A., Ariawan, D., Ittner, L. & Martin, A.
1/01/21 → 31/12/23
Project: Research
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Clearance of TDP-43 by PROteolysis TArgeting Chimera (PROTAC) dual targeting to treat amyotrophic lateral sclerosis (ALS)
Lee, A., Rayner, S., Martin, A., van Hummel, A., Morsch, M., Shi, B., Ke, Y., Ittner, L. & Chung, R.
4/05/20 → 3/05/21
Project: Research
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TDP-43 pathology and functional deficits in wild-type and ALS/FTD mutant cyclin F mouse models
van Hummel, A., Sabale, M., Przybyla, M., van der Hoven, J., Chan, G., Feiten, A. F., Chung, R. S., Ittner, L. M. & Ke, Y. D., Apr 2023, In: Neuropathology and Applied Neurobiology. 49, 2, p. 1-12 12 p., e12902.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Downloads (Pure) -
Differential mitochondrial protein interaction profile between human translocator protein and its A147T polymorphism variant
Asih, P. R., Poljak, A., Kassiou, M., Ke, Y. D. & Ittner, L. M., 6 May 2022, In: PLoS ONE. 17, 5, p. 1-16 16 p., e0254296.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)3 Downloads (Pure) -
Efficient gene expression in human stem cell derived-cortical organoids using adeno associated virus
Cho, A-N., Bright, F., Morey, N., Au, C., Ittner, L. M. & Ke, Y. D., 11 Oct 2022, In: Cells. 11, 20, p. 1-13 13 p., 3194.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)5 Downloads (Pure) -
Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer's disease
Deng, Y., Bi, M., Delerue, F., Forrest, S. L., Chan, G., van der Hoven, J., van Hummel, A., Feiten, A. F., Lee, S., Martinez-Valbuena, I., Karl, T., Kovacs, G. G., Morahan, G., Ke, Y. D. & Ittner, L. M., Oct 2022, In: Acta Neuropathologica. 144, 4, p. 637-650 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)9 Downloads (Pure) -
Recent progress in synthetic self-adjuvanting vaccine development
Ariawan, D., van Eersel, J., Martin, A. D., Ke, Y. D. & Ittner, L. M., 26 Jul 2022, In: Biomaterials Science. 10, 15, p. 4037-4057 21 p.Research output: Contribution to journal › Review article › peer-review
3 Citations (Scopus)
Prizes
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UNSW School of Medical Sciences New Researcher of the Year 2015
Ke, Yazi (Recipient), 14 Dec 2015
Prize
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