Projects per year
Personal profile
Biography
Associate Professor Yazi Ke is the Deputy Director (Operations) of the Dementia Research Centre and Associate Professor in the Department of Biomedical Sciences of the Faculty of Medicine and Health Sciences at Macquarie University. After obtaining her PhD (Medicine) from University of Sydney (USyd) in Dec 2009, Yazi became a postdoctoral research associate at the Brain and Mind Research Institute, USyd (2010-2013). In July 2013, she moved to University of NSW (UNSW) to join the Dementia Research Unit headed by Prof. Lars Ittner as a research-only Lecturer with an ongoing ARC DECRA fellowship (2013-2016). During her time at UNSW, she was promoted to Senior Lecturer (July 2017) and is a successful recipient of the NHMRC Career Development Fellowship (R.D. Wright Biomedical; 2017-2020).
Research interests
Yazi has made seminal contributions throughout her research career to our current understanding of disease processes in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Her research program and interests includes:
- Developing and characterising new and improved models of FTD and ALS using both traditional transgenesis and AAV approaches
- Deciphering the functions of pathogenic mutations in neurodegenerative diseases
Education/Academic qualification
Neuroscience, PhD, University of Sydney
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Projects 2018 2020
Novel pathomechanisms and therapeutic targets in neurodegenerative diseases
1/12/18 → 30/09/20
Project: Other
The Role of LIM Domain Kinase 1 in the Pathogenesis of Alzheimer’s Disease
Ke, Y., Ittner, A., Tan, R. H., Halliday, G., Krill, J., Ittner, L., Klugmann, M., Kassiou, M. & Gunning, P.
1/11/18 → 31/12/20
Project: Other
Site-specific Tau Phosphorylation to Treat and Understand Alzheimer’s Disease
Ittner, A., Ke, Y., Poljak, A., Ittner, L. & Klugmann, M.
1/11/18 → 31/12/20
Project: Other
The role of TDP-43 pathology-associated astrocytosis in Motor Neuron Disease.
1/11/18 → 30/04/19
Project: Other
Research Outputs 2006 2019
Adeno-associated virus-based Alzheimer's disease mouse models and potential new therapeutic avenues
Ittner, L. M., Klugmann, M. & Ke, Y. D., 1 Sep 2019, In : British Journal of Pharmacology. 176, 18, p. 3649-3665 17 p.Research output: Contribution to journal › Review article › Research › peer-review
CNS cell type-specific gene profiling of P301S tau transgenic mice identifies genes dysregulated by progressive tau accumulation
Ke, Y. D., Chan, G., Stefanoska, K., Au, C., Bi, M., Müller, J., Przybyla, M., Feiten, A., Prikas, E., Halliday, G. M., Piguet, O., Kiernan, M. C., Kassiou, M., Hodges, J. R., Loy, C. T., Mattick, J. S., Ittner, A., Kril, J. J., Sutherland, G. T. & Ittner, L. M., 20 Sep 2019, In : Journal of Biological Chemistry. 294, 38, p. 14149-14162 14 p.Research output: Contribution to journal › Article › Research › peer-review
Developmental expression of mutant PFN1 in motor neurons impacts neuronal growth and motor performance of young and adult mice
Brettle, M., Stefen, H., Djordjevic, A., Fok, S. Y. Y., Chan, J. W., van Hummel, A., van der Hoven, J., Przybyla, M., Volkerling, A., Ke, Y. D., Delerue, F., Ittner, L. M. & Fath, T., 27 Sep 2019, In : Frontiers in Molecular Neuroscience. 12, p. 1-12 12 p., 231.Research output: Contribution to journal › Article › Research › peer-review
Alzheimer’s disease and frontotemporal lobar degeneration: mouse models
Ittner, L. M., Lee, W. S., Stefanoska, K., Asih, P. R. & Ke, Y. D., 1 Jan 2018, NeurodegeneratIve diseases: clinical aspects, molecular genetics and biomarkers. Galimberti, D. & Scarpini, E. (eds.). Second ed. Springer, Springer Nature, p. 187-219 33 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review
An N-terminal motif unique to primate tau enables differential protein–protein interactions
Stefanoska, K., Volkerling, A., Bertz, J., Poljak, A., Ke, Y. D., Ittner, L. M. & Ittner, A., 9 Mar 2018, In : Journal of Biological Chemistry. 293, 10, p. 3710-3719 10 p.Research output: Contribution to journal › Article › Research › peer-review
Prizes
UNSW School of Medical Sciences New Researcher of the Year 2015
Yazi Ke (Recipient), 14 Dec 2015
Prize