Projects per year
Personal profile
Biography
Professor Yazi Ke is the Deputy Director (Research and Operations) of the Dementia Research Centre and Professor in the Department of Biomedical Sciences of the Faculty of Medicine and Health Sciences at Macquarie University. After obtaining her PhD (Medicine) from University of Sydney (USyd) in Dec 2009, Yazi became a postdoctoral research associate at the Brain and Mind Research Institute, USyd (2010-2013). In July 2013, she moved to University of NSW (UNSW) to join the Dementia Research Unit headed by Prof. Lars Ittner as a research-only Lecturer with an ongoing ARC DECRA fellowship (2013-2016). During her time at UNSW, she was promoted to Senior Lecturer (July 2017) and is a successful recipient of the NHMRC Career Development Fellowship (R.D. Wright Biomedical; 2017-2020).
Research interests
Yazi has made seminal contributions throughout her research career to our current understanding of disease processes in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Her research program and interests includes:
- Developing and characterising new and improved models of FTD and ALS using both traditional transgenesis and AAV approaches
- Deciphering the functions of pathogenic mutations in neurodegenerative diseases
Education/Academic qualification
Neuroscience, PhD, Parkinsonism and impaired axonal transport in a novel mouse model of frontotemporal dementia and pick's disease, University of Sydney
Award Date: 14 Dec 2009
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Advancing cell-targeted and immune-resistant gene therapy for frontotemporal dementia and motor neuron disease
Ke, Y., van Hummel, A., Ariawan, D., Ittner, L. & Rowe, D.
1/10/24 → 30/09/27
Project: Research
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FightMND DDG: Translating a novel gene therapy for MND towards clinical testing
Ittner, L., Ke, Y., Lisowski, L., Hamdorf, B. & Rowe, D.
1/02/24 → 31/01/27
Project: Research
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IDEAS 23: Development of next-generation gene therapy vectors for the treatment of epilepsy
Van Eersel, J., Ittner, L. & Ke, Y.
1/01/24 → 31/12/26
Project: Research
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2022 NHMRC Ideas: Inhibition failure in Alzheimer's disease
Ittner, L., van der Hoven, J., Deng, Y., Forrest, S., Ke, Y. & Kovacs, G.
1/01/23 → 31/12/26
Project: Research
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PLP1-targeting antisense oligonucleotides improve FOXG1 syndrome mice
Tan, D. C. S., Jung, S., Deng, Y., Morey, N., Chan, G., Bongers, A., Ke, Y. D., Ittner, L. M. & Delerue, F., 9 Oct 2024, In: International Journal of Molecular Sciences. 25, 19, p. 1-21 21 p., 10846.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Downloads (Pure) -
Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice
Ke, Y. D., van Hummel, A., Au, C., Chan, G., Lee, W. S., van der Hoven, J., Przybyla, M., Deng, Y., Sabale, M., Morey, N., Bertz, J., Feiten, A., Ippati, S., Stevens, C. H., Yang, S., Gladbach, A., Haass, N. K., Kril, J. J., Blair, I. P., Delerue, F., & 1 others, 17 Apr 2024, In: Neuron. 112, 8, p. 1249-1264.e8 25 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus) -
Methyl donor supplementation reduces phospho-Tau, Fyn and demethylated protein phosphatase 2A levels and mitigates learning and motor deficits in a mouse model of tauopathy
van Hummel, A., Taleski, G., Sontag, J-M., Feiten, A. F., Ke, Y. D., Ittner, L. M. & Sontag, E., 11 Aug 2023, In: Neuropathology and Applied Neurobiology. 49, 4, p. 1-13 13 p., e12931.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)79 Downloads (Pure) -
SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity
Martínez-Mármol, R., Giordano-Santini, R., Kaulich, E., Cho, A. N., Przybyla, M., Riyadh, M. A., Robinson, E., Chew, K. Y., Amor, R., Meunier, F. A., Balistreri, G., Short, K. R., Ke, Y. D., Ittner, L. M. & Hilliard, M. A., 7 Jun 2023, In: Science Advances. 9, 23, p. 1-14 14 p., eadg2248.Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Citations (Scopus)48 Downloads (Pure) -
TDP-43 pathology and functional deficits in wild-type and ALS/FTD mutant cyclin F mouse models
van Hummel, A., Sabale, M., Przybyla, M., van der Hoven, J., Chan, G., Feiten, A. F., Chung, R. S., Ittner, L. M. & Ke, Y. D., Apr 2023, In: Neuropathology and Applied Neurobiology. 49, 2, p. 1-12 12 p., e12902.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)110 Downloads (Pure)
Prizes
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UNSW School of Medical Sciences New Researcher of the Year 2015
Ke, Yazi (Recipient), 14 Dec 2015
Prize
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