Projects per year
Personal profile
Biography
Professor Yazi Ke is the Deputy Director (Research and Operations) of the Dementia Research Centre and Professor in the Department of Biomedical Sciences of the Faculty of Medicine and Health Sciences at Macquarie University. After obtaining her PhD (Medicine) from University of Sydney (USyd) in Dec 2009, Yazi became a postdoctoral research associate at the Brain and Mind Research Institute, USyd (2010-2013). In July 2013, she moved to University of NSW (UNSW) to join the Dementia Research Unit headed by Prof. Lars Ittner as a research-only Lecturer with an ongoing ARC DECRA fellowship (2013-2016). During her time at UNSW, she was promoted to Senior Lecturer (July 2017) and is a successful recipient of the NHMRC Career Development Fellowship (R.D. Wright Biomedical; 2017-2020).
Research interests
Yazi has made seminal contributions throughout her research career to our current understanding of disease processes in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Her research program and interests includes:
- Developing and characterising new and improved models of FTD and ALS using both traditional transgenesis and AAV approaches
- Deciphering the functions of pathogenic mutations in neurodegenerative diseases
Education/Academic qualification
Neuroscience, PhD, Parkinsonism and impaired axonal transport in a novel mouse model of frontotemporal dementia and pick's disease, University of Sydney
Award Date: 14 Dec 2009
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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DARF 2024: Piecing together the role of TDP43 in the Alzheimer’s disease puzzle
van Hummel, A. (Primary Chief Investigator), Ittner, L. (Associate Investigator) & Ke, Y. (Associate Investigator)
1/07/25 → 1/07/27
Project: Research
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FightMND 24: Inhibition failure in Motor Neuron Disease
Ittner, L. (Primary Chief Investigator), Ke, Y. (Co-Investigator) & Deng, Y. (Co-Investigator)
1/03/25 → 29/02/28
Project: Research
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FightMND 24: Developing novel disease-specific gene therapy vectors for MND
Ke, Y. (Primary Chief Investigator) & Ittner, L. (Chief Investigator)
1/03/25 → 28/02/27
Project: Research
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FightMND 24: Developing new MND disease models to study TDP-43 pathology
van Hummel, A. (Primary Chief Investigator), Ke, Y. (Co-Investigator) & Ittner, L. (Co-Investigator)
1/02/25 → 31/01/27
Project: Research
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FightMND 24: Pathway to Precision: Developing Specific TDP-43 Degraders for MND
Ke, Y. (Primary Chief Investigator), Ittner, L. (Chief Investigator), Tietz, O. (Chief Investigator) & Rowe, D. (Partner Investigator)
1/02/25 → 31/01/28
Project: Research
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PLP1-targeting antisense oligonucleotides improve FOXG1 syndrome mice
Tan, D. C. S., Jung, S., Deng, Y., Morey, N., Chan, G., Bongers, A., Ke, Y. D., Ittner, L. M. & Delerue, F., 9 Oct 2024, In: International Journal of Molecular Sciences. 25, 19, p. 1-21 21 p., 10846.Research output: Contribution to journal › Article › peer-review
Open AccessFile34 Downloads (Pure) -
Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice
Ke, Y. D., van Hummel, A., Au, C., Chan, G., Lee, W. S., van der Hoven, J., Przybyla, M., Deng, Y., Sabale, M., Morey, N., Bertz, J., Feiten, A., Ippati, S., Stevens, C. H., Yang, S., Gladbach, A., Haass, N. K., Kril, J. J., Blair, I. P. & Delerue, F. & 1 others, , 17 Apr 2024, In: Neuron. 112, 8, p. 1249-1264.e8 25 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Citations (Scopus) -
Methyl donor supplementation reduces phospho-Tau, Fyn and demethylated protein phosphatase 2A levels and mitigates learning and motor deficits in a mouse model of tauopathy
van Hummel, A., Taleski, G., Sontag, J.-M., Feiten, A. F., Ke, Y. D., Ittner, L. M. & Sontag, E., 11 Aug 2023, In: Neuropathology and Applied Neurobiology. 49, 4, p. 1-13 13 p., e12931.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)64 Downloads (Pure) -
SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity
Martínez-Mármol, R., Giordano-Santini, R., Kaulich, E., Cho, A. N., Przybyla, M., Riyadh, M. A., Robinson, E., Chew, K. Y., Amor, R., Meunier, F. A., Balistreri, G., Short, K. R., Ke, Y. D., Ittner, L. M. & Hilliard, M. A., 7 Jun 2023, In: Science Advances. 9, 23, p. 1-14 14 p., eadg2248.Research output: Contribution to journal › Article › peer-review
Open AccessFile48 Citations (Scopus)48 Downloads (Pure) -
TDP-43 pathology and functional deficits in wild-type and ALS/FTD mutant cyclin F mouse models
van Hummel, A., Sabale, M., Przybyla, M., van der Hoven, J., Chan, G., Feiten, A. F., Chung, R. S., Ittner, L. M. & Ke, Y. D., Apr 2023, In: Neuropathology and Applied Neurobiology. 49, 2, p. 1-12 12 p., e12902.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)105 Downloads (Pure)