• 103 Citations
  • 5 h-Index
20162019
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Personal profile

Biography

Dr. Dheer obtained Bachelors and Masters in Pharmacy from Department of Pharmaceutical Sciences and Drug Research, Punjabi University, India. Based on her academic background she joined Prof. Stuart Graham’s group for doing PhD studies in Clinical Medicine from Macquarie University, NSW. Her area of research focuses on identifying the mechanisms underlying retinal neurodegeneration in various disease conditions and developing pharmacological therapeutics to protect retinal neurons. Currently, she is a postdoctoral fellow investigating interactions between neuroserpin (a specific enzyme inhibitor) and amyloid beta in the brain and retina in Alzheimer’s disease (AD). Her research utilizes various pharmacological, molecular biology and cell culture based techniques.

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Glaucoma Medicine & Life Sciences
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Alzheimer Disease Medicine & Life Sciences
trkB Receptor Medicine & Life Sciences

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Research Output 2016 2019

  • 103 Citations
  • 5 h-Index
  • 13 Article
  • 1 Meeting abstract
  • 1 Short survey
  • 1 Review article

Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease

You, Y., Joseph, C., Wang, C., Gupta, V., Liu, S., Yiannikas, C., Chua, B., Chitranshi, N., Shen, T., Dheer, Y., Invernizzi, A., Borotkanics, R., Barnett, M., Graham, S. L. & Klistorner, A., 1 Feb 2019, In : Brain; a journal of neurology. 142, 2, p. 426-442 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Demyelinating Diseases
Neurodegenerative Diseases
Radiation
Myelin Sheath
Neuroglia

Loss of Shp2 rescues BDNF/TrkB signaling and contributes to improved retinal ganglion cell neuroprotection

Chitranshi, N., Dheer, Y., Mirzaei, M., Wu, Y., Salekdeh, G. H., Abbasi, M., Gupta, V., Vander Wall, R., You, Y., Graham, S. L. & Gupta, V., 6 Feb 2019, In : Molecular Therapy. 27, 2, p. 424-441 18 p.

Research output: Contribution to journalArticleResearchpeer-review

trkB Receptor
Retinal Ganglion Cells
Glaucoma
Endoplasmic Reticulum Stress
Apoptosis
Retinoid X Receptors
Molecular Dynamics Simulation
Transcription Factors
Pharmacology
Ligands

Retinoid x receptor modulation protects against ER stress response and rescues glaucoma phenotypes in adult mice

Dheer, Y., Chitranshi, N., Gupta, V., Sharma, S., Pushpitha, K., Abbasi, M., Mirzaei, M., You, Y., Graham, S. L. & Gupta, V., 1 Apr 2019, In : Experimental Neurology. 314, p. 111-125 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinoid X Receptors
Retinoids
Glaucoma
Phenotype
Retina
Protein Biosynthesis
Amyloid beta-Protein Precursor
Retina
Alzheimer Disease
Up-Regulation