A neuro-biomechanical model of the pharynx during breathing and swallowing

The pharynx enables breathing, eating, & speech, but its biomechanics and neuromuscular control are poorly understood. This project will solve this via an integrated series of experimental and modelling studies. Experimental work will elucidate the neural circuitry and molecular basis for pharyngeal sensation and neural control and pharyngeal function. These data will then be integrated into a 3D neuro-biomechanical model of the pharynx to simulate breathing and swallowing. This will provide the first full understanding of pharyngeal mechanosensory machinery and how neural drive, anatomy & sensation interact during breathing and swallowing. The model will provide a platform for future development of oral devices and sensors.