A Prelude towards transforming adenoid cystic carcinoma into an immune hot tumour

Salivary gland adenoid cystic carcinoma (ACC) is known as immune cold tumour, contrastingly mucoepidermoid carcinoma (MEC) of salivary gland is considered immune hot tumour. ACC tumour microenvironment (TME) exhibit very low infiltration of immune cells. So far, apoptosis has been found to tune tumour immunity based on the demonstration of apoptosis of immune cells (T effector cells), that undermines the anti-tumour reactivity of immune cells in the tumour microenvironment. This eventually facilitates growth of T regulatory cells, M2 macrophage, and myeloid derived suppressor cells.