Adenoid cystic carcinoma (ACC) is a rare salivary gland cancer most frequently arising in head and neck region. ACC microenvironment exhibits low immunogenicity, favouring immune evasion. A hook-related protein, Gipie, was found to have roles in inflammation and immune response. However, Gipie is aberrantly expressed in some ACC cells. This project aims to investigate whether Gipie can prevent ACC cells from being targeted by immune cells.
|Short title||Adenoid cystic carcinoma immune evasion|
|Effective start/end date||1/10/21 → 30/09/22|