This project aims to advance the understanding of molecular basis of antibiotic resistance in bacteria at the single cell level, using an innovative approach integrating microfluidics, microscopy and genomics. The study of
individual bacterial cells is essential to provide fundamental insights into heterogeneous resistance, a well recognised major component of antibiotic resistance. Expected outcomes include new platform technology for
high-throughput multiplexed screening and improved knowledge of bacteria heterogeneity for drug discovery. This interdisciplinary project should yield significant benefits in society and economy by reducing healthcare costs,
promoting good health for Australian and commercialising advanced technologies.