Characterising CHCHD10-induced TDP-43 mitochondria entry in MND

Mitochondria are the powerhouse of all cells in our body. Healthy mitochondria generate energy and determine the life-death fate of the cell. In MND, mitochondria can be harmed by a key disease protein called TDP-43, which does not usually reside in the mitochondria. In MND, it can enter mitochondria and cause damage. We recently found a new protein that 4 can control whether or not TDP-43 enters mitochondria. In this study, we will identify the mechanism behind this phenomenon in a unique new MND cell model and determine if this protein can safeguard mitochondria from TDP-43’s damage. This will provide new avenues for therapies.