Developing brain-targeted artificial viral vectors for gene delivery in the treatment of glioblastoma

Gene therapy has been proved a promising and powerful strategy for cancer treatment, but efficient targeted gene delivery in vivo has so far remained challenging, especially for brain tumours. While viral vectors can deliver genetic drugs to the brain, they may trigger dangerous immune responses in patients. Nano-sized particles (NPs) are designed to help protect gene product from being broken down or cleared before they can reach the target site, reduce the retention of gene drugs within normal tissues and deliver them to the site of action. Meanwhile, reducing the immune response by engineering the NPs with natural or biomimetic materials. Here, we are supposed to develop a well-tailored and versatile “core-shell” artificial viral vectors for systemic gene delivery to treat glioblastoma.