Development of computational models to predict delivery of inhalation drug powders: from deagglomeration in devices to deposition in airways

This research proposal presents a framework that has been strategically designed to develop a universal model that can be used to accurately predict active pharmaceutical ingredient (API) powder aerosolization and deposition in physiologically realistic airways and for a wide range of dry powder inhaler (DPI) systems. The outcome of this research will be a novel coupled computational fluid dynamics (CFD), discrete element method (DEM) model and discrete phase model (DPM) with proven abilities to quantitatively predict both the agglomeration and deagglomeration of carrier-API systems in dry powder inhalers (DPIs) and the respiratory airways.