Does inflammation in the brain lead to hypertension in kidney disease?

Project: Research

Project Details


In kidney disease, hypertension is a significant factor in the development of cardiovascular disease and death resulting from heart-attack, cardiac-arrest and stroke. The brain has pathways that can respond to substances found in the blood and we have established a key part of this pathway is overactive in kidney disease and causing hypertension. Important blood-borne substances that can activate this pathway are molecules called cytokines, which are excreted from immune cells and promote inflammation (proinflammatory cytokines). In kidney disease proinflammatory cytokines in the blood increase and may be producing hypertension. It is also possible that proinflammatory cytokines are being
produced by immune cells in the brain. We will test these hypothesesexamining in a rodent model of kidney disease if: (1) proinflammatory cytokines stimulate the brain to produce hypertension; (2) levels of proinflammatory cytokines and their receptors within the brain are increased; (3) immune cells within the brain have become activated.
Effective start/end date1/07/19 → 1/06/20