Project Details
Description
MND Australia PhD top-up grant 2025-2027
In almost all people living with MND, a protein called TDP-43 malfunctions, forming toxic clumps and losing its ability to perform critical functions in cells. There is currently no way to stop or treat this, however, emerging evidence suggests that another protein called ataxin-3 may be able to help. This project will be the first to establish how the ataxin-3 protein may have beneficial effects against toxic, malfunctioning TDP-43 protein in both human cell and zebrafish models of MND. This knowledge could guide future research on a treatment for malfunctioning TDP-43, which would likely benefit most people living with MND.
In almost all people living with MND, a protein called TDP-43 malfunctions, forming toxic clumps and losing its ability to perform critical functions in cells. There is currently no way to stop or treat this, however, emerging evidence suggests that another protein called ataxin-3 may be able to help. This project will be the first to establish how the ataxin-3 protein may have beneficial effects against toxic, malfunctioning TDP-43 protein in both human cell and zebrafish models of MND. This knowledge could guide future research on a treatment for malfunctioning TDP-43, which would likely benefit most people living with MND.
| Acronym | MNDRA |
|---|---|
| Status | Active |
| Effective start/end date | 1/01/25 → 31/12/27 |