Genetic and lifestyle susceptibility and resilience factors affecting rates of change in preclinical Alzheimer's Disease

At the early stages of Alzheimer's Disease (AD) significant variability in the rates of memory deterioration and accumulation of AD associated changes in the brain exist. Certain factors (genes, lifestyle) may play a major role in determining the rates of change e.g. decline (risk factors) or stability (resilience factors). The proposed study will attempt to define the genetic and lifestyle factors and how they may interact to underpin the rates at which these changes occur.