People with joint hypermobility disorders often report symptoms of “orthostatic intolerance” (OI) such as faintness, when they stand upright. This has a significant impact on their quality of life e.g. reduced attendance at school/work. At present, there is no proven treatment to reduce these symptoms due to a lack of appreciation of the underpinning mechanisms. This study seeks to obtain world-first quantitative data on the prevalence and mechanisms of OI in this condition. The relationship between arterial stiffness and cardio/cerebro-vascular regulation during postural challenges will be assessed. The findings will pave the way for future studies aimed at mitigating the short- and long-term impacts of OI in joint hypermobility disorders.
|Short title||OI and EDS-HT/JHS|
|Effective start/end date||1/01/18 → 31/12/19|