Investigating the prevalence and mechanisms of orthostatic intolerance in young adults with joint hypermobility disorders

People with joint hypermobility disorders often report symptoms of “orthostatic intolerance” (OI) such as faintness, when they stand upright. This has a significant impact on their quality of life e.g. reduced attendance at school/work.  At present, there is no proven treatment to reduce these symptoms due to a lack of appreciation of the underpinning mechanisms. This study seeks to obtain world-first quantitative data on the prevalence and mechanisms of OI in this condition. The relationship between arterial stiffness and cardio/cerebro-vascular regulation during postural challenges will be assessed. The findings will pave the way for future studies aimed at mitigating the short- and long-term impacts of OI in joint hypermobility disorders.