Metformin, gut epithelium and microbiome in the prevention of colorectal cancer

Prevention of colorectal cancer (CRC) saves lives. Metformin, a safe drug clinically used as an anti-diabetic therapy, has been shown to suppress cancer. Yet, its successful implementation as a CRC preventative is limited by a lack of knowledge on how metformin elicits these anti-cancer effects. Our project will provide a holistic understanding of how metformin impacts the colon lining, its microbiome and CRC development.