Optimise Sleep in Brain Ageing and Neurodegeneration (CogSleep)

  • Naismith, Sharon (Chief Investigator)
  • Grunstein, Ronald R. (Chief Investigator)
  • Lewis, Simon J G (Chief Investigator)
  • Phillips, Craig L. (Chief Investigator)
  • D'Rozario, Angela L. (Chief Investigator)
  • Hoyos, Camilla M. (Chief Investigator)
  • Rajaratnam, Shanthakumar W. (Chief Investigator)
  • Halliday, Glenda (Chief Investigator)
  • Martins, Ralph (Chief Investigator)
  • Lagopoulos, Jim (Chief Investigator)
  • Saini, Bandana (Associate Investigator)
  • Gordon, Christopher J. (Associate Investigator)
  • Sutherland, Greg T. (Associate Investigator)
  • Hickie, Ian (Associate Investigator)
  • Kwok, John B. (Associate Investigator)
  • Mowszowski, Loren (Associate Investigator)
  • Soberats, Maria Comas (Associate Investigator)
  • Calvo, Rafael (Associate Investigator)
  • Adams, Robert (Associate Investigator)
  • Duffy, Shantel (Associate Investigator)

    Project: Research

    Project Details

    Description

    It is increasingly recognized that various disturbances of the sleep or circadian (sleep-wake) systems are aetiologically linked to brain
    degeneration in ageing, with recent research suggesting these relationships are likely to be bidirectional. Sleep-wake disturbance can occur
    decades before the onset of dementia and appears to play a key role in neuro-vascular dysfunction, and the build-up of alpha-synuclein and betaamyloid
    in the brain, key proteins that underpin dementia. In addition, obstructive sleep apnoea leads to sleep fragmentation and hypoxaemia in
    the brain, with adverse effects on alertness, cognition and daytime functioning.
    There is relatively little information available on the mechanisms by which sleep-wake disturbance may exert deleterious effects and how it
    relates to regional structural or brain network dysfunction. There are few established treatments for sleep-wake disturbances in these groups, and
    there is a need to increase clinical research capacity in this field.
    AcronymNHMRC_CRE_USyd
    StatusFinished
    Effective start/end date1/11/1831/10/23