Project Details
Description
It is increasingly recognized that various disturbances of the sleep or circadian (sleep-wake) systems are aetiologically linked to brain
degeneration in ageing, with recent research suggesting these relationships are likely to be bidirectional. Sleep-wake disturbance can occur
decades before the onset of dementia and appears to play a key role in neuro-vascular dysfunction, and the build-up of alpha-synuclein and betaamyloid
in the brain, key proteins that underpin dementia. In addition, obstructive sleep apnoea leads to sleep fragmentation and hypoxaemia in
the brain, with adverse effects on alertness, cognition and daytime functioning.
There is relatively little information available on the mechanisms by which sleep-wake disturbance may exert deleterious effects and how it
relates to regional structural or brain network dysfunction. There are few established treatments for sleep-wake disturbances in these groups, and
there is a need to increase clinical research capacity in this field.
degeneration in ageing, with recent research suggesting these relationships are likely to be bidirectional. Sleep-wake disturbance can occur
decades before the onset of dementia and appears to play a key role in neuro-vascular dysfunction, and the build-up of alpha-synuclein and betaamyloid
in the brain, key proteins that underpin dementia. In addition, obstructive sleep apnoea leads to sleep fragmentation and hypoxaemia in
the brain, with adverse effects on alertness, cognition and daytime functioning.
There is relatively little information available on the mechanisms by which sleep-wake disturbance may exert deleterious effects and how it
relates to regional structural or brain network dysfunction. There are few established treatments for sleep-wake disturbances in these groups, and
there is a need to increase clinical research capacity in this field.
| Acronym | NHMRC_CRE_USyd |
|---|---|
| Status | Active |
| Effective start/end date | 1/11/18 → 31/10/23 |